Modeling the Impact of Process Variation on Critical Charge Distribution

2006 ◽  
Author(s):  
Qian Ding ◽  
Rong Luo ◽  
Hui Wang ◽  
Huazhong Yang ◽  
Yuan Xie
Keyword(s):  
Charge Distribution ◽  
Process Variation ◽  
Critical Charge ◽  
The Impact

On the Impact of Within-Die Process Variation in GALS-Based NoC Performance

2012 ◽  
Vol 31 (2) ◽  
pp. 294-307 ◽  
Author(s):  
Carles Hernandez ◽  
Antoni Roca ◽  
Federico Silla ◽  
Jose Flich ◽  
Jose Duato
Keyword(s):  
Process Variation ◽  
The Impact

The Impact of Charge-Distribution on Photochromic Properties in 1D Coordination Polymers

2017 ◽  
Vol 643 (22) ◽  
pp. 1766-1770 ◽  
Author(s):  
Jian-Jun Liu ◽  
Shu-Biao Xia ◽  
Liu Teng ◽  
Chi-Xian He ◽  
Fei-Xiang Cheng ◽  
...  
Keyword(s):  
Charge Distribution ◽  
Coordination Polymers ◽  
Photochromic Properties ◽  
The Impact

Reversible and Switching Parts of Polarization in PZT Films

1999 ◽  
Vol 596 ◽  
Author(s):  
Vladimir Petrovsky ◽  
Harlan U. Anderson ◽  
Tatiana Petrovsky ◽  
Alexander Grishin
Keyword(s):  
Space Charge ◽  
Hysteresis Loop ◽  
Charge Distribution ◽  
Domain Structure ◽  
Remanent Polarization ◽  
Polarization State ◽  
Theoretical Limit ◽  
Pzt Films ◽  
Space Charge Distribution ◽  
The Impact

AbstractA pulsing technique was used for more detailed investigation of the switching process in ferroelectric PZT films. This technique allows for the separation of the switching and reversible parts of the polarization and an estimation of the impact of the different effects in the hysteresis loop such as domain structure, depolarizing field and space charge distribution. It is shown that it is possible to provide nondestructive readout of the information stored as the polarization state by measuring the nonlinearity of the reversible polarization. Theoretical limit for the nondestructive readout signal is 20% of the remanent polarization in the differential regime and 12% in the direct regime. The experimental value of the signal is 10% in the both regimes and does not depend on time or the number of readings.

scholarly journals Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies

2021 ◽  
Author(s):  
Jakob C Stueber ◽  
Saša M. Miladinović ◽  
Thomas Poeschinger ◽  
Tamara Zimmermann ◽  
Remi Villenave ◽  
...  
Keyword(s):  
Charge Distribution ◽  
Interstitial Fluid ◽  
Tumor Bearing ◽  
Organ Uptake ◽  
Specific Assessment ◽  
Vitro Model ◽  
Antibody Levels ◽  
The Impact ◽  
Total Tissue

This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture of three antibodies engineered to carry negative charge patches, a balanced charge distribution, or positive patches, respectively. Tissue levels were analyzed with a specific LC-MS/MS method. In addition, the antibody mix was administered to non-tumor bearing mice. Muscle and skin interstitial fluid were obtained by centrifugation and analyzed by LC-MS/MS. An in-vitro endothelium model was explored for its feasibility to mimic the observed distribution differences. A balanced charge distribution was optimal in terms of total tumor exposure, while in other tissues negatively charged and balanced charged antibodies gave similar results. In contrast, positive charge patches generally result in increased serum clearance but markedly enhance tumor and organ uptake, leading to higher tissue-to-serum ratios. The uptake and availability in the interstitial space were confirmed by specific assessment of antibody levels in the interstitial fluid of muscle and skin, with similar charge impact as in total tissue. The in vitro model was able to differentiate the transport propensity of this series of antibody variants. In summary, our results show the differential effects of charge patches on an antibody surface on biodistribution and tumor uptake. These insights may help in the design of molecules with biodistribution properties tailored to their purpose and an optimized safety profile.

scholarly journals IMPACT OF THE GRAPHENE SYNTHESIS AND CONCENTRATION CONDITIONS ON ELECTRICAL PARAMETERS OF GRAPHENE — GRAPHITE SYSTEM

2021 ◽  
Vol 87 (8) ◽  
pp. 127-137
Author(s):  
Radyslav Panteleimonov ◽  
Oleksandr Boichuk ◽  
Katherine Pershina ◽  
Volodymyr Ogenko
Keyword(s):  
Heat Treatment ◽  
Aqueous Medium ◽  
Charge Distribution ◽  
Electrochemical Impedance ◽  
Arc Discharge ◽  
Electrical Parameters ◽  
Active Resistance ◽  
Distribution Maps ◽  
Graphene Synthesis ◽  
The Impact

Electrochemical impedance spectroscopy was used to study the electrical parameters of graphite-graphene systems with different mass concentrations of graphene. Graphene was synthesized using two methods of plasma arc discharge from aqueous and non-aqueous medium (water and liquid nitrogen) to determine the impact of graphite concentration, water, and heat treatment of graphene on electrical parameters (conductivity and electrostatic capacity) of the graphite-graphene mixture. The average va­lues ​​of active resistance and electrostatic capacity of these systems are obtained. The optimal ratio of components with high capacitance and conductivity, which was 1: 1. The influence of heat treatment adsorbed on the graphene surface of the water and mass fraction of graphite on the change of electrical parameters of the system is shown. Comparison of the values ​​of capacity and active resistance of the samples showed that the presence of water in graphene reduces the average values ​​of capacity relative to graphene without water by 10 times and symbolically increases the active resistance at a mass ratio of graphene to graphite 1: 3, and at a ratio of 1: 1 values ​​are proportional. Comparison of resistance, capacitance, and charge distribution calculations in a graphite-graphene mixture in the frequency range 10–2 ÷ 103 Hz established the effect of heat treatment on increasing the values ​​of capacitance and active resistance. Heat treatment at 2500C of graphene, synthesized from an aqueous medium, leads to an increase in the values ​​of capacitance and conductivity, which occurs due to a different distribution of charges on the surface. Analysis of charge distribution maps shows that water adsorbed on the surface of graphene in the presence of a signi­ficant amount of graphite can be a factor in interfering with the distribution of charge carriers and significantly reduce the conductivity and electrostatic capacity of the system.

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