A power-free blood plasma extraction device based on planar crossflow filter microstructure

2009 ◽  
Author(s):  
Yu Chang Kim ◽  
Seung-Hoon Kim ◽  
Pil Woo Heo ◽  
Je-Kyun Park
Keyword(s):  
Blood Plasma ◽  
Extraction Device ◽  
Plasma Extraction

scholarly journals 8H-08 Blood Plasma Extraction Device Using Dielectrophoresis-assisted Erythrocyte Sedimentation

2011 ◽  
Vol 2010.23 (0) ◽  
pp. 155-156
Author(s):  
Fumiya TAKADA ◽  
Takashi ARAKAWA ◽  
Hiroki KANAMORI ◽  
Makoto YAMANAKA ◽  
Takashi YASUDA
Keyword(s):  
Blood Plasma ◽  
Erythrocyte Sedimentation ◽  
Extraction Device ◽  
Plasma Extraction

Proposal of Micro Plasma Extraction Device by Autonomous Trigger Control

2020 ◽  
Vol 140 (4) ◽  
pp. 437-442
Author(s):  
Hiroki Naito ◽  
Shunya Okamoto ◽  
Yoshiaki Ukita
Keyword(s):  
Extraction Device ◽  
Plasma Extraction

scholarly journals Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1366
Author(s):  
Jaehoon Kim ◽  
Junghyo Yoon ◽  
Jae-Yeong Byun ◽  
Hyunho Kim ◽  
Sewoon Han ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Microfluidic Device ◽  
Blood Cells ◽  
Extraction Method ◽  
Membrane Filter ◽  
Point Of Care ◽  
Extraction Yield ◽  
Microfluidic Channels ◽  
Point Of Care Testing ◽  
Plasma Extraction

Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μL of extracted plasma with a high extraction yield (~45%) in 16 min.

scholarly journals Low-cost, disposable microfluidics device for blood plasma extraction using continuously alternating paramagnetic and diamagnetic capture modes

2016 ◽  
Vol 10 (2) ◽  
pp. 024110 ◽  
Author(s):  
Pilkee Kim ◽  
Eng Hui Ong ◽  
King Ho Holden Li ◽  
Yong-Jin Yoon ◽  
Sum Huan Gary Ng ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Low Cost ◽  
Plasma Extraction

High Throughput Cell-Free Extraction of Plasma by an Integrated Microfluidic Device Combining Inertial Focusing and Membrane

2017 ◽  
Vol 139 (5) ◽  
Author(s):  
Jun Zhang ◽  
Sheng Yan ◽  
Dan Yuan ◽  
Gursel Alici ◽  
Nam-Trung Nguyen ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Microfluidic Device ◽  
High Throughput ◽  
Membrane Filtration ◽  
Membrane Filter ◽  
Whole Body ◽  
Inertial Focusing ◽  
High Efficient ◽  
Plasma Extraction

Plasma is a host of numerous analytes such as proteins, metabolites, circulating nucleic acids (CNAs), and pathogens, and it contains massive information about the functioning of the whole body, which is of great importance for the clinical diagnosis. Plasma needs to be completely cell-free for effective detection of these analytes. The key process of plasma extraction is to eliminate the contamination from blood cells. Centrifugation, a golden standard method for blood separation, is generally lab-intensive, time consuming, and even dangerous to some extent, and needs to be operated by well-trained staffs. Membrane filtration can filter cells very effectively according to its pore size, but it is prone to clogging by dense particle concentration and suffers from limited capacity of filtration. Frequent rinse is lab-intensive and undesirable. In this work, we proposed and fabricated an integrated microfluidic device that combined particle inertial focusing and membrane filter for high efficient blood plasma separation. The integrated microfluidic device was evaluated by the diluted (×1/10, ×1/20) whole blood, and the quality of the extracted blood plasma was measured and compared with that from the standard centrifugation. We found that the quality of the extracted blood plasma from the proposed device can be equivalent to that from the standard centrifugation. This study demonstrates a significant progress toward the practical application of inertial microfluidics with membrane filter for high-throughput and highly efficient blood plasma extraction.

2C31 LSPR measurement in a microchannel for automatic blood plasma extraction

2015 ◽  
Vol 2015.27 (0) ◽  
pp. 403-404
Author(s):  
Hiroki KANAMORI ◽  
Koji AIHARA ◽  
Makoto YAMANAKA ◽  
Takashi YASUDA
Keyword(s):  
Blood Plasma ◽  
Plasma Extraction

Ultra-low aspect ratio spiral microchannel with ordered micro-bars for flow-rate insensitive blood plasma extraction

2019 ◽  
Vol 287 ◽  
pp. 320-328 ◽  
Author(s):  
Shaofei Shen ◽  
Fangjuan Zhang ◽  
Shuting Wang ◽  
Jiangran Wang ◽  
Dandan Long ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Blood Plasma ◽  
Flow Rate ◽  
Low Aspect Ratio ◽  
Spiral Microchannel ◽  
Plasma Extraction

scholarly journals Proposal of micro plasma extraction device by autonomous trigger control

2020 ◽  
Vol 103 (9) ◽  
pp. 29-35
Author(s):  
Hiroki Naito ◽  
Shunya Okamoto ◽  
Yoshiaki Ukita
Keyword(s):  
Extraction Device ◽  
Plasma Extraction
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