A Unified ME Algorithm for Arbitrary Open QNMs with Mixed Blocking Mechanisms

2011 ◽  
Author(s):  
Jumma S. Alanazi ◽  
Demetres D. Kouvatsos
Keyword(s):  
Blocking Mechanisms

Bilinguals reveal blocking mechanisms underlying tip-of-the-tongue states

2010 ◽  
Author(s):  
Tamar H. Gollan ◽  
Victor S. Ferreira ◽  
Cynthia Cera ◽  
Susanna Flett
Keyword(s):  
Blocking Mechanisms ◽  
Tip Of The Tongue

Potential of Mesenchymal Stem Cells in Anti-Cancer Therapies

2020 ◽  
Vol 15 (6) ◽  
pp. 482-491 ◽  
Author(s):  
Milena Kostadinova ◽  
Milena Mourdjeva
Keyword(s):  
Cancer Cells ◽  
Small Population ◽  
Tumor Formation ◽  
Bioactive Molecules ◽  
Cancer Therapies ◽  
New Methods ◽  
Cycle Arrest ◽  
Anti Cancer ◽  
Blocking Mechanisms

Mesenchymal stem/stromal cells (MSCs) are localized throughout the adult body as a small population in the stroma of the tissue concerned. In injury, tissue damage, or tumor formation, they are activated and leave their niche to migrate to the site of injury, where they release a plethora of growth factors, cytokines, and other bioactive molecules. With the accumulation of data about the interaction between MSCs and tumor cells, the dualistic role of MSCs remains unclear. However, a large number of studies have demonstrated the natural anti-tumor properties inherent in MSCs, so this is the basis for intensive research for new methods using MSCs as a tool to suppress cancer cell development. This review focuses specifically on advanced approaches in modifying MSCs to become a powerful, precision- targeted tool for killing cancer cells, but not normal healthy cells. Suppression of tumor growth by MSCs can be accomplished by inducing apoptosis or cell cycle arrest, suppressing tumor angiogenesis, or blocking mechanisms mediating metastasis. In addition, the chemosensitivity of cancer cells may be increased so that the dose of the chemotherapeutic agent used could be significantly reduced.

scholarly journals Fouling layer characterization and pore-blocking mechanisms in an UF membrane externally coupled to a UASB reactor

Water SA ◽  
2017 ◽  
Vol 43 (4) ◽  
pp. 573 ◽  
Author(s):  
Mónica L Salazar-Peláez ◽  
Juan Manuel Morgan-Sagastume ◽  
Adalberto Noyola
Keyword(s):  
Uasb Reactor ◽  
Pore Blocking ◽  
Blocking Mechanisms

Heuristics for scheduling in a Kanban system with dual blocking mechanisms

1997 ◽  
Vol 103 (3) ◽  
pp. 439-452 ◽  
Author(s):  
B. Sharadapriyadarshini ◽  
Chandrasekharan Rajendran
Keyword(s):  
Blocking Mechanisms ◽  
Kanban System

scholarly journals New Aspects of Pathogenesis and Treatment of Membranous Glomerulopathy After the MENTOR Study

2020 ◽  
pp. 46-53
Author(s):  
Maurizio Salvadori ◽  
Aris Tsalouchos
Keyword(s):  
Nephrotic Syndrome ◽  
Adrenocorticotropic Hormone ◽  
Glomerular Diseases ◽  
The Past ◽  
Superior Efficacy ◽  
Novel Drugs ◽  
Membranous Glomerulopathy ◽  
Blocking Mechanisms ◽  
Antigenic Epitopes

Membranous nephropathy (MN) is the major cause of nephrotic syndrome in adults, accounting for 20% of cases with an annual incidence of 1 per 100,000 population. In the past 10 years, the role of podocytes has been identified. Environmental triggers in genetically predisposed patients can activate podocytes to exhibit antigenic epitopes, including PLA2R, THBS1, and NELL1, which become targets of specific autoantibodies with subsequent complement activation. The discovery of these mechanisms has opened a new horizon in the treatment of MN, and novel drugs are available with more specific mechanisms of action. Rituximab, a monoclonal antibody directed against CD20 expressed on B lymphocytes, has been used in several trials and appears to induce remission of nephrotic syndrome in 60% of patients (GEMRITUX trial). The recently published results of the MENTOR trial documented the superior efficacy of rituximab in patients observed for up to 24 months. In MN, the concept of targeting disease control has introduced novel therapies with specific blocking mechanisms, such as belimumab; nonspecific blocking mechanisms, such as those against adrenocorticotropic hormone; and new therapeutic options, such as ofatumumab, bortezomib, and eculizumab, which have recognised the pathological processes involved in the glomerular diseases.

scholarly journals Deep bed filtration with multiple pore-blocking mechanisms

2018 ◽  
Vol 196 ◽  
pp. 04003 ◽  
Author(s):  
Liudmila Kuzmina ◽  
Yuri Osipov
Keyword(s):  
Porous Medium ◽  
Size Exclusion ◽  
Medium Size ◽  
Deep Bed Filtration ◽  
Pore Blocking ◽  
Variable Porosity ◽  
Monodisperse Suspension ◽  
Porosity And Permeability ◽  
Constant Coefficients ◽  
Blocking Mechanisms

A one-dimensional model for the deep bed filtration of a monodisperse suspension in a porous medium with variable porosity and permeability and multiple pore-blocking mechanisms is considered. It is assumed that the small pores are clogged by separate particles; pores of medium size, exceeding the diameter of the particles, can be blocked by arched bridges, forming stable structures at the pore throats. These pore-blocking mechanisms - size-exclusion and different types of bridging act simultaneously. Exact solutions are obtained for constant coefficients, on the concentrations front and at the porous medium inlet.

scholarly journals Micellar-Enhanced Ultrafiltration Using a Plant-Derived Surfactant for Dye Separation in Wastewater Treatment

Membranes ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 220
Author(s):  
Nita Aryanti ◽  
Aininu Nafiunisa ◽  
Tutuk Djoko Kusworo ◽  
Dyah Hesti Wardhani
Keyword(s):  
Membrane Fouling ◽  
Surfactant Micelle ◽  
Natural Surfactant ◽  
Cake Formation ◽  
Natural Surfactants ◽  
Environmentally Safe ◽  
Micellar Enhanced Ultrafiltration ◽  
Blocking Mechanisms ◽  
Remazol Red ◽  
Blocking Mechanism

Micellar-enhanced ultrafiltration (MEUF) is one of several membrane methods used for the removal of trace organic pollutants from aqueous streams. In this process, a surfactant is added to a polluted aqueous solution at a concentration higher than its critical micelle concentration (CMC). Unlike synthetic surfactants, natural surfactants, from plants such as the saponin, while ecologically adaptable as surfactants in MEUF systems, are also biodegradable, renewable, and environmentally safe. This study applied Sapindus rarak extract as the natural surfactant in MEUF for Remazol dye separation. It was found that the presence of Sapindus rarak extract increased separation of Remazol red and blue dyes by up to 97.02% and 99.42%, respectively. However, the addition of surfactant decreased permeate fluxes due to membrane fouling and concentration polarization. In addition, loading micelle (Lm), representing the performance of the surfactant micelle for dye separation, as well as the blocking mechanism, was investigated. Lm was found to be in the range of 0.002–0.068 mM dyes/mM saponin. Ultrafiltration blocking mechanisms, as confirmed by the Hermia model, were: standard blocking, for cases without the addition of surfactant; cake formation, for cases with surfactant below the CMC; and complete blocking, for cases with surfactant above the CMC.

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