Influence of encapsulation tissue reaction on the volume of tissue activated with deep-brain stimulation electrodes: A simulation study

2015 ◽  
Author(s):  
Milan Djilas ◽  
Andre Mercanzini ◽  
Pascal Harbi ◽  
Alain Dransart ◽  
Saso Jezernik
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Simulation Study ◽  
Tissue Reaction ◽  
Deep Brain

scholarly journals Investigation into Deep Brain Stimulation Lead Designs: A Patient-Specific Simulation Study

2016 ◽  
Vol 6 (3) ◽  
pp. 39 ◽  
Author(s):  
Fabiola Alonso ◽  
Malcolm Latorre ◽  
Nathanael Göransson ◽  
Peter Zsigmond ◽  
Karin Wårdell
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Simulation Study ◽  
Patient Specific ◽  
Deep Brain

Postmortem analysis following 71 months of deep brain stimulation of the subthalamic nucleus for Parkinson disease

2008 ◽  
Vol 109 (2) ◽  
pp. 325-329 ◽  
Author(s):  
David A. Sun ◽  
Hong Yu ◽  
John Spooner ◽  
Armanda D. Tatsas ◽  
Thomas Davis ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Zona Incerta ◽  
Foreign Body Giant Cell ◽  
Stn Dbs ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective neurosurgical treatment for Parkinson disease. Tissue reaction to chronic DBS therapy and the definitive location of active stimulation contacts are best studied on a postmortem basis in patients who have undergone DBS. The authors report the postmortem analysis of STN DBS following 5 years and 11 months of effective chronic stimulation including the histologically verified location of the active contacts associated with bilateral implants. They also describe tissue response to intraoperative test passes with recording microelectrodes and stimulating semimacroelectrodes. The results indicated that 1) the neural tissue surrounding active and nonactive contacts responds similarly, with a thin glial capsule and foreign-body giant cell reaction surrounding the leads as well as piloid gliosis, hemosiderin-laden macrophages, scattered lymphocytes, and Rosenthal fibers; 2) there was evidence of separate tracts in the adjacent tissue for intraoperative microelectrode and semimacroelectrode passes together with reactive gliosis, microcystic degeneration, and scattered hemosiderin deposition; and 3) the active contacts used for ~ 6 years of effective bilateral DBS therapy lie in the zona incerta, just dorsal to the rostral STN. To the authors' knowledge, the period of STN DBS therapy herein described for Parkinson disease and subjected to postmortem analysis is the longest to date.

scholarly journals Local SAR near deep brain stimulation (DBS) electrodes at 64 and 127 MHz: A simulation study of the effect of extracranial loops

2016 ◽  
Vol 78 (4) ◽  
pp. 1558-1565 ◽  
Author(s):  
Laleh Golestanirad ◽  
Leonardo M. Angelone ◽  
Maria Ida Iacono ◽  
Husam Katnani ◽  
Lawrence L. Wald ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Simulation Study ◽  
Local Sar ◽  
Deep Brain

Brain Tissue Reaction to Deep Brain Stimulation-A Longitudinal Study of DBS in the Goettingen Minipig

2017 ◽  
Vol 20 (5) ◽  
pp. 417-423 ◽  
Author(s):  
Dariusz Orlowski ◽  
Alexandre Michalis ◽  
Andreas N. Glud ◽  
Anders R. Korshøj ◽  
Lise M. Fitting ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Deep Brain Stimulation ◽  
Brain Tissue ◽  
Brain Stimulation ◽  
Tissue Reaction ◽  
Deep Brain

scholarly journals Electric Field Comparison between Microelectrode Recording and Deep Brain Stimulation Systems—A Simulation Study

2018 ◽  
Vol 8 (2) ◽  
pp. 28 ◽  
Author(s):  
Fabiola Alonso ◽  
Dorian Vogel ◽  
Johannes Johansson ◽  
Karin Wårdell ◽  
Simone Hemm
Keyword(s):  
Deep Brain Stimulation ◽  
Electric Field ◽  
Brain Stimulation ◽  
Simulation Study ◽  
Microelectrode Recording ◽  
Deep Brain
Sign in / Sign up

Export Citation Format

Share Document