Brain Tissue Reaction to Deep Brain Stimulation-A Longitudinal Study of DBS in the Goettingen Minipig

2017 ◽  
Vol 20 (5) ◽  
pp. 417-423 ◽  
Author(s):  
Dariusz Orlowski ◽  
Alexandre Michalis ◽  
Andreas N. Glud ◽  
Anders R. Korshøj ◽  
Lise M. Fitting ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Deep Brain Stimulation ◽  
Brain Tissue ◽  
Brain Stimulation ◽  
Tissue Reaction ◽  
Deep Brain

Deep Brain Stimulation as a Treatment for Neuropathic Pain: A Longitudinal Study Addressing Neuropsychological Outcomes

2014 ◽  
Vol 15 (3) ◽  
pp. 283-292 ◽  
Author(s):  
Alan M. Gray ◽  
Elizabeth Pounds-Cornish ◽  
Fiona J.R. Eccles ◽  
Tipu Z. Aziz ◽  
Alexander L. Green ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Longitudinal Study ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Neuropsychological Outcomes ◽  
Deep Brain

MONOPHASIC BUT NOT BIPHASIC PULSES INDUCE BRAIN TISSUE DAMAGE DURING MONOPOLAR HIGH-FREQUENCY DEEP BRAIN STIMULATION

Neurosurgery ◽  
2009 ◽  
Vol 64 (1) ◽  
pp. 156-163 ◽  
Author(s):  
Brigitte Piallat ◽  
Stéphan Chabardès ◽  
Annaelle Devergnas ◽  
Napoleon Torres ◽  
Marjolaine Allain ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Tissue ◽  
Brain Stimulation ◽  
Tissue Damage ◽  
High Frequency ◽  
Brain Tissue Damage ◽  
Deep Brain

Postmortem analysis following 71 months of deep brain stimulation of the subthalamic nucleus for Parkinson disease

2008 ◽  
Vol 109 (2) ◽  
pp. 325-329 ◽  
Author(s):  
David A. Sun ◽  
Hong Yu ◽  
John Spooner ◽  
Armanda D. Tatsas ◽  
Thomas Davis ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Zona Incerta ◽  
Foreign Body Giant Cell ◽  
Stn Dbs ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective neurosurgical treatment for Parkinson disease. Tissue reaction to chronic DBS therapy and the definitive location of active stimulation contacts are best studied on a postmortem basis in patients who have undergone DBS. The authors report the postmortem analysis of STN DBS following 5 years and 11 months of effective chronic stimulation including the histologically verified location of the active contacts associated with bilateral implants. They also describe tissue response to intraoperative test passes with recording microelectrodes and stimulating semimacroelectrodes. The results indicated that 1) the neural tissue surrounding active and nonactive contacts responds similarly, with a thin glial capsule and foreign-body giant cell reaction surrounding the leads as well as piloid gliosis, hemosiderin-laden macrophages, scattered lymphocytes, and Rosenthal fibers; 2) there was evidence of separate tracts in the adjacent tissue for intraoperative microelectrode and semimacroelectrode passes together with reactive gliosis, microcystic degeneration, and scattered hemosiderin deposition; and 3) the active contacts used for ~ 6 years of effective bilateral DBS therapy lie in the zona incerta, just dorsal to the rostral STN. To the authors' knowledge, the period of STN DBS therapy herein described for Parkinson disease and subjected to postmortem analysis is the longest to date.

scholarly journals Has Deep Brain Stimulation Changed the Very Long‐Term Outcome of Parkinson's Disease? A Controlled Longitudinal Study

2020 ◽  
Vol 7 (7) ◽  
pp. 782-787 ◽  
Author(s):  
Philipp Mahlknecht ◽  
Marina Peball ◽  
Katherina Mair ◽  
Mario Werkmann ◽  
Michael Nocker ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Longitudinal Study ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Deep Brain
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