Reduced Growth Rate of Tumors from Melanoma B16 Cells Exposed to Focused Shock Waves

Author(s):  
P. Sunka ◽  
V. Stelmashuk ◽  
J. Benes ◽  
P. Pouckova
Keyword(s):  
Author(s):  
Masaaki Tamagawa ◽  
Norikazu Ishimatsu

This paper describes effects of shock waves on cells to certificate the angiogenesis by shock wave (pressure wave) in the clinical application such as ESW (Extracorporeal Shock Wave). Especially, to investigate the effects of shock waves on the endothelial cells in vitro, the cells worked by plane shock waves using shock tube apparatus are observed and measured in the microscope. The peak pressure working on the endothelial cells at the test case is 0.4 MPa. After working shock waves on suspended cells, growth rate (area per one cell and population of cells) are measured by image processing. It is found that the growth rate of the shock-worked cells from 0 to 4h is clearly high compared with control one. It is concluded that once shock waves worked, the cells have capacity to increase growth rate in vitro. This preliminary result will be applied to fundamental investigations about shock wave stimulus on several kinds of cells in future.


1984 ◽  
Vol 32 (1) ◽  
pp. 159-178 ◽  
Author(s):  
S. T. Tsai ◽  
M. Tanaka ◽  
J. D. Gaffey ◽  
E. H. Da Jornada ◽  
C. S. Wu ◽  
...  

The investigation of the kinetic cross-field streaming instability, motivated by the research of collisionless shock waves and previously studied by Wu et al., is discussed more fully in the present work. Since, in the ramp region of a quasi-perpendicular shock, electrons can be preferentially heated in the direction transverse to the ambient magnetic field, it is both desirable and necessary to include the effect of the thermal anisotropy on the instability associated with a shock. The present study has found that Te⊥ > Te‖ can significantly enhance the peak growth rate of the cross-field streaming instability when the electron beta is sufficiently high. Furthermore, the present analysis also improves the analytical and numerical solutions previously obtained.


Author(s):  
Masaaki Tamagawa ◽  
Norikazu Ishimatsu

This paper describes effects of shock waves on cells to certificate the angiogenesis by shock wave (pressure wave) in the clinical application such as ESW (Extracorporeal Shock Wave). Especially, to investigate the effects of shock waves on the endothelial cells in vitro, the cells worked by plane shock waves using shock tube apparatus are observed by microscope. The peak pressure working on the endothelial cells at the test case is 0.4 MPa. After working shock waves on suspended cells, the disintegration, shape and growth rate (area per one cell and population of cells) are measured by image processing. It is found that the younger generation cells have small differences of shape index, and the growth rate of the shock-worked cells from 0 to 4h are clearly high compared with control ones. It is concluded that once shock waves worked, some of them are disintegrated, but the other has capacity to increase growth rate of cell culture in vitro. This preliminary result will be applied to fundamental investigations about shock wave stimulus on several kinds of cells in future.


Author(s):  
M.A. Mogilevsky ◽  
L.S. Bushnev

Single crystals of Al were loaded by 15 to 40 GPa shock waves at 77 K with a pulse duration of 1.0 to 0.5 μs and a residual deformation of ∼1%. The analysis of deformation structure peculiarities allows the deformation history to be re-established.After a 20 to 40 GPa loading the dislocation density in the recovered samples was about 1010 cm-2. By measuring the thickness of the 40 GPa shock front in Al, a plastic deformation velocity of 1.07 x 108 s-1 is obtained, from where the moving dislocation density at the front is 7 x 1010 cm-2. A very small part of dislocations moves during the whole time of compression, i.e. a total dislocation density at the front must be in excess of this value by one or two orders. Consequently, due to extremely high stresses, at the front there exists a very unstable structure which is rearranged later with a noticeable decrease in dislocation density.


Author(s):  
Wilfried Sigle ◽  
Matthias Hohenstein ◽  
Alfred Seeger

Prolonged electron irradiation of metals at elevated temperatures usually leads to the formation of large interstitial-type dislocation loops. The growth rate of the loops is proportional to the total cross-section for atom displacement,which is implicitly connected with the threshold energy for atom displacement, Ed . Thus, by measuring the growth rate as a function of the electron energy and the orientation of the specimen with respect to the electron beam, the anisotropy of Ed can be determined rather precisely. We have performed such experiments in situ in high-voltage electron microscopes on Ag and Au at 473K as a function of the orientation and on Au as a function of temperature at several fixed orientations.Whereas in Ag minima of Ed are found close to <100>,<110>, and <210> (13-18eV), (Fig.1) atom displacement in Au requires least energy along <100>(15-19eV) (Fig.2). Au is thus the first fcc metal in which the absolute minimum of the threshold energy has been established not to lie in or close to the <110> direction.


2020 ◽  
Vol 640 ◽  
pp. A53
Author(s):  
L. Löhnert ◽  
S. Krätschmer ◽  
A. G. Peeters

Here, we address the turbulent dynamics of the gravitational instability in accretion disks, retaining both radiative cooling and irradiation. Due to radiative cooling, the disk is unstable for all values of the Toomre parameter, and an accurate estimate of the maximum growth rate is derived analytically. A detailed study of the turbulent spectra shows a rapid decay with an azimuthal wave number stronger than ky−3, whereas the spectrum is more broad in the radial direction and shows a scaling in the range kx−3 to kx−2. The radial component of the radial velocity profile consists of a superposition of shocks of different heights, and is similar to that found in Burgers’ turbulence. Assuming saturation occurs through nonlinear wave steepening leading to shock formation, we developed a mixing-length model in which the typical length scale is related to the average radial distance between shocks. Furthermore, since the numerical simulations show that linear drive is necessary in order to sustain turbulence, we used the growth rate of the most unstable mode to estimate the typical timescale. The mixing-length model that was obtained agrees well with numerical simulations. The model gives an analytic expression for the turbulent viscosity as a function of the Toomre parameter and cooling time. It predicts that relevant values of α = 10−3 can be obtained in disks that have a Toomre parameter as high as Q ≈ 10.


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