DCIS Cube: Defining Architecture Building Blocks for Next Generation Deployable IT Systems

2018 ◽  
Author(s):  
Marc van Selm ◽  
Hermann Wietgrefe ◽  
Joel Varanda ◽  
Detlef Janezic
Keyword(s):  
Building Blocks ◽  
Next Generation ◽  
It Systems

scholarly journals Recent Progress in the Synthesis and Characterization of Diarylethene-based MOFs

2014 ◽  
Vol 70 (a1) ◽  
pp. C1223-C1223
Author(s):  
Jason Benedict ◽  
Ian Walton ◽  
Dan Patel ◽  
Jordan Cox
Keyword(s):  
Chemical Properties ◽  
Building Blocks ◽  
Synthesis And Characterization ◽  
Next Generation ◽  
Design Synthesis ◽  
Thermally Induced ◽  
Potential Applications ◽  
External Stimuli ◽  
Physical And Chemical

Metal-organic Frameworks (MOFs) remain an extremely active area of research given the wide variety of potential applications and the enormous diversity of structures that can be created from their constituent building blocks. While MOFs are typically employed as passive materials, next-generation materials will exhibit structural and/or electronic changes in response to applied external stimuli including light, charge, and pH. Herein we present recent results in which advanced photochromic diarylethenes are combined with MOFs through covalent and non-covalent methods to create photo-responsive permanently porous crystalline materials. This presentation will describe the design, synthesis, and characterization of next-generation photo-switchable diarylethene based ligands which are subsequently used to photo-responsive MOFs. These UBMOF crystals are, by design, isostructural with previously reported non-photoresponsive frameworks which enables a systematic comparison of their physical and chemical properties. While the photoswitching of the isolated ligand in solution is fully reversible, the cycloreversion reaction is suppressed in the UBMOF single crystalline phase. Spectroscopic evidence for thermally induced cycloreversion will be presented, as well as a detailed analysis addressing the limits of X-ray diffraction techniques applied to these systems.

scholarly journals Digitally Enabled Health Service for the Integrated Management of Hypertension: A Participatory User-Centred Design Process

2021 ◽  
Vol 18 (23) ◽  
pp. 12442
Author(s):  
Vincenzo De De Luca ◽  
Vanja Lazic ◽  
Strahil Birov ◽  
Klaus Piesche ◽  
Ozan Beyhan ◽  
...  
Keyword(s):  
Healthcare Professionals ◽  
Healthy Lifestyle ◽  
Integrated Management ◽  
Integrated Approach ◽  
Building Blocks ◽  
Process Models ◽  
Functional Requirements ◽  
Health Care Organisation ◽  
Care Organisation ◽  
It Systems

This article describes a user-centred approach taken by a group of five procurers to set specifications for the procurement of value-based research and development services for IT-supported integrated hypertension management. The approach considered the unmet needs of patients and health systems of the involved regions. The procurers established a framework for requirements and a solution design consisting of nine building blocks, divided into three domains: service delivery, devices and integration, and health care organisation. The approach included the development of questionnaires, capturing patients’ and professionals’ views on possible system functionalities, and a template collecting information about the organisation of healthcare, professionals involved and existing IT systems at the procurers’ premises. A total of 28 patients diagnosed with hypertension and 26 professionals were interviewed. The interviewees identified 98 functional requirements, grouped in the nine building blocks. A total of nine use cases and their corresponding process models were defined by the procurers’ working group. As result, a digitally enabled integrated approach to hypertension has been designed to allow citizens to learn how to prevent the development of hypertension and lead a healthy lifestyle, and to receive comprehensive, individualised treatment in close collaboration with healthcare professionals.

Bringing It All Together (Data Mining on an Enterprise Level)

2001 ◽  
pp. 119-136
Author(s):  
Stephan Kudyba ◽  
Richard Hoptroff
Keyword(s):  
Data Mining ◽  
Business Performance ◽  
Value Added ◽  
Building Blocks ◽  
Complex Nature ◽  
It Systems ◽  
Brick And Mortar ◽  
Key Issues ◽  
Enterprise Level ◽  
Business User

Up to now we have presented the fundamental building blocks to understanding the concept of data mining and addressed the prevailing applications within the corporate environment including both the “brick and mortar” style and e-commerce spectrums. The process does not stop here however. In order to implement mining on an enterprise basis, firms must overcome some potentially serious obstacles and address key issues. The more complex nature of data mining generally limits its use to a smaller population of individuals in a given firm, (although this is not always the case). Because of this, a common drawback to the process of effective Mining is the communication of value-added model results to corresponding users of this information. Just as there exists a gap between IT personnel, (those who know the technical side of systems) and the business user, (those who require IT systems to help solve their problems), there also exists a communication gap between the “data miners” and those who need to apply the resulting models to help solve their business problem. Other issues which must be considered before implementing an organization wide mining approach entails the development of total mining solutions instead of limiting applications to a few business problems. Decision makers must also avoid the trap of relying too heavily on mining results and must remember that these models are not crystal ball providers of perfect knowledge. Because of this, they must therefore monitor actual business performance against projected measures to maintain model effectiveness and accuracy.

Complementary Resistive Switches (CRS): High speed performance for the application in passive nanocrossbar arrays

2011 ◽  
Vol 1337 ◽  
Author(s):  
Roland Rosezin ◽  
Eike Linn ◽  
Lutz Nielen ◽  
Carsten Kügeler ◽  
Rainer Bruchhaus ◽  
...  
Keyword(s):  
High Speed ◽  
Simple Procedure ◽  
Electrical Characterization ◽  
Building Blocks ◽  
Next Generation ◽  
High Uniformity ◽  
Non Volatile Memory ◽  
Speed Performance ◽  
Resistive Switches

ABSTRACTIn this report, the fabrication and electrical characterization of fully vertically integrated complementary resistive switches (CRS), which consist of two anti-serially connected Cu-SiO2 memristive elements, is presented. The resulting CRS cells are initialized by a simple procedure and show high uniformity of resistance states afterwards. Furthermore, the CRS cells show high switching speeds below 50 ns, making them excellent building blocks for next generation non-volatile memory based on passive nanocrossbar arrays.

Naphtho[2,1-b:3,4-b′]bisthieno[3,2-b][1]benzothiophene-based semiconductors for organic field-effect transistors

2015 ◽  
Vol 3 (31) ◽  
pp. 8024-8029 ◽  
Author(s):  
Zhaoguang Li ◽  
Ji Zhang ◽  
Kai Zhang ◽  
Weifeng Zhang ◽  
Lei Guo ◽  
...  
Keyword(s):  
Organic Semiconductors ◽  
Field Effect ◽  
High Performance ◽  
Field Effect Transistors ◽  
Hole Mobility ◽  
Building Blocks ◽  
Organic Field Effect Transistors ◽  
Next Generation

Naphtho[2,1-b:3,4-b′]bisthieno[3,2-b][1]benzothiophene derivatives exhibiting a hole mobility of up to 0.25 cm2 V−1 s−1 show promise as useful building blocks to construct next-generation high performance organic semiconductors.

scholarly journals A Multiplexed Bacterial Two-Hybrid for Rapid Characterization of Protein-Protein Interactions and Iterative Protein Design

2020 ◽  
Author(s):  
W. Clifford Boldridge ◽  
Ajasja Ljubetič ◽  
Hwangbeom Kim ◽  
Nathan Lubock ◽  
Dániel Szilágyi ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Coiled Coil ◽  
Building Blocks ◽  
Coiled Coils ◽  
Next Generation ◽  
Protein Protein Interactions ◽  
Library Size ◽  
Large Sets ◽  
Synthetic Cell ◽  
Two Hybrid

AbstractMyriad biological functions require protein-protein interactions (PPIs), and engineered PPIs are crucial for applications ranging from drug design to synthetic cell circuits. Understanding and engineering specificity in PPIs is particularly challenging as subtle sequence changes can drastically alter specificity. Coiled-coils are small protein domains that have long served as a simple model for studying the sequence-determinants of specificity and have been used as modular building blocks to build large protein nanostructures and synthetic circuits. Despite their simple rules and long-time use, building large sets of well-behaved orthogonal pairs that can be used together is still challenging because predictions are often inaccurate, and, as the library size increases, it becomes difficult to test predictions at scale. To address these problems, we first developed a method called the Next-Generation Bacterial Two-Hybrid (NGB2H), which combines gene synthesis, a bacterial two-hybrid assay, and a high-throughput next-generation sequencing readout, allowing rapid exploration of interactions of programmed protein libraries in a quantitative and scalable way. After validating the NGB2H system on previously characterized libraries, we designed, built, and tested large sets of orthogonal synthetic coiled-coils. In an iterative set of experiments, we assayed more than 8,000 PPIs, used the dataset to train a novel linear model-based coiled-coil scoring algorithm, and then characterized nearly 18,000 interactions to identify the largest set of orthogonal PPIs to date with twenty-two on-target interactions.

scholarly journals Proteins as Sustainable Building Blocks for the Next Generation of Bioinorganic Nanomaterials

Biochemistry ◽  
2018 ◽  
Vol 58 (3) ◽  
pp. 140-141 ◽  
Author(s):  
Marcel Lach ◽  
Matthias Künzle ◽  
Tobias Beck
Keyword(s):  
Building Blocks ◽  
Next Generation ◽  
Sustainable Building

Sustainable IT Ecosystems: Enabling Next-Generation Cities

2011 ◽  
Author(s):  
Christopher Hoover ◽  
Brian Watson ◽  
Ratnesh Sharma ◽  
Sue Charles ◽  
Amip Shah ◽  
...  
Keyword(s):  
Data Analytics ◽  
Integrated Design ◽  
Building Blocks ◽  
Autonomous Control ◽  
Management Approach ◽  
Urban Water ◽  
Next Generation ◽  
Life Cycle Design ◽  
Pervasive Sensing ◽  
Control Application

In this paper, we describe an integrated design and management approach for building next-generation cities. This approach leverages IT technology in both the design and operational phases to optimize sustainability over a broad set of metrics while lowering costs. We call this approach a Sustainable IT Ecosystem. Our approach is based on five principles: ecosystem-scale life-cycle design; scalable and configurable infrastructure building blocks; pervasive sensing; data analytics and visualization; and autonomous control. Application of the approach is demonstrated for two case studies: an urban water infrastructure and an urban power microgrid. We conclude by discussing future opportunities to co-design and integrate these independent infrastructures, gaining further efficiencies.

Tending and Trekking towards Composite Oriented Architecture (COA)

2010 ◽  
pp. 386-414
Author(s):  
Pethuru Raj Chelliah
Keyword(s):  
Business Processes ◽  
Building Blocks ◽  
End Users ◽  
Government Agencies ◽  
Service Orientation ◽  
Next Generation ◽  
On Demand ◽  
The Future

With the noteworthy spurt of service orientation (SO) principles, the spur and surge for composition paradigm have taken a fabulous and fruitful dimension and perspective. Composites are emerging and establishing as the promising, proven and potential building-blocks in the pulsating ICT space. Enterprises are very optimistic and sensitive about the shining days of composites in their day-to-day dealings and obligations to their restive partners, government agencies, venerable customers, demanding end-users, and loyal employees. In short, composites are bound to increasingly and illuminatingly participate and contribute towards fulfilling the goals of realizing integrated, optimized, smart and lean business processes that in turn can lead to extended, connected, adaptive, and on-demand businesses. As next-generation ICT is presumed to thrive on spontaneous and seamless collaboration among systems, services, servers, sensors, etc. by sending messages as well as smartly sharing a wider variety of connected and empowered resources, there arises a distinct identity and value for progressive, penetrative and pervasive composites. Already we started to read, hear and experience composite applications, services, and views. As composition is to flower and flourish in a positive fashion, the future IT is definitely on right track. In this chapter, you can find discussions about how rapidly and smoothly services enable business-aligned composites realization. There are sections dealing with prominent composition paradigms, patterns, platforms, processes, practices, products, perspectives, problems and potentials.

Standards? What and Why?

2011 ◽  
pp. 3433-3448
Author(s):  
Phil Long ◽  
Frank Tansey
Keyword(s):  
Systems Design ◽  
Building Blocks ◽  
Learning Systems ◽  
Next Generation ◽  
Complex Learning ◽  
E Learning ◽  
Learning Software

Specifications define the nature of the interconnections between the distinct parts of complex learning systems, but not their boundaries.  Next generation CMS tools are emerging from standards discussions that challenge current e-learning systems design boundaries. They raise the prospect of a complex but smoothly functioning set of components and services that aggregate in ways that best serve individual communities of users. Users need to engage in the process to express their requirements for e-learning software. These building blocks, produced by a small number of organizations, are establishing the framework that will enable CMS environments to become vastly different than the CMS you might now be using.

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