Design and characterization of a lab-on-chip for continuous bioluminescent measurements of ATP

2014 ◽  
Author(s):  
Shilun Feng ◽  
Tao Dong
Keyword(s):  
Lab On Chip ◽  
On Chip

Thermal Modeling and Characterization of a Thin-Film Heater on Glass Substrate for Lab-on-Chip Applications

2015 ◽  
Vol 64 (5) ◽  
pp. 1098-1098 ◽  
Author(s):  
Andrea Scorzoni ◽  
Michele Tavernelli ◽  
Pisana Placidi ◽  
Stefano Zampolli
Keyword(s):  
Thin Film ◽  
Glass Substrate ◽  
Thermal Modeling ◽  
Lab On Chip ◽  
On Chip

Thermal characterization of thin film heater for lab-on-chip application

2015 ◽  
Author(s):  
Giulia Petrucci ◽  
Domenico Caputo ◽  
Augusto Nascetti ◽  
Nicola Lovecchio ◽  
Emanuele Parisi ◽  
...  
Keyword(s):  
Thin Film ◽  
Thermal Characterization ◽  
Lab On Chip ◽  
On Chip

Fabrication and characterization of aluminum thin film heaters and temperature sensors on a photopolymer for lab-on-chip systems

2013 ◽  
Vol 193 ◽  
pp. 170-181 ◽  
Author(s):  
J. Martinez-Quijada ◽  
S. Caverhill-Godkewitsch ◽  
M. Reynolds ◽  
L. Gutierrez-Rivera ◽  
R.W. Johnstone ◽  
...  
Keyword(s):  
Thin Film ◽  
Temperature Sensors ◽  
Lab On Chip ◽  
Aluminum Thin Film ◽  
Fabrication And Characterization ◽  
On Chip

Characterization of size-dependent mechanical properties of tip-growing cells using a lab-on-chip device

Lab on a Chip ◽  
2017 ◽  
Vol 17 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Chengzhi Hu ◽  
Gautam Munglani ◽  
Hannes Vogler ◽  
Tohnyui Ndinyanka Fabrice ◽  
Naveen Shamsudhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Cell Wall ◽  
Young’S Modulus ◽  
Microfluidic Device ◽  
Young's Modulus ◽  
Turgor Pressure ◽  
Lab On Chip ◽  
Size Dependent ◽  
On Chip

A microfluidic device can trap and indent tip-growing cells for quantification of turgor pressure and cell wall Young's modulus.

LAB-ON-CHIP-BASED CELL SEPARATION BY COMBINING DIELECTROPHORESIS AND CENTRIFUGATION

2006 ◽  
Vol 01 (04) ◽  
pp. 443-451 ◽  
Author(s):  
MICHAEL BOETTCHER ◽  
MAGNUS S. JAEGER ◽  
LUTZ RIEGGER ◽  
JENS DUCRÉE ◽  
ROLAND ZENGERLE ◽  
...  
Keyword(s):  
Cell Separation ◽  
Low Cost ◽  
Pharmaceutical Research ◽  
Successful Implementation ◽  
Cell Therapies ◽  
Lab On Chip ◽  
Autologous Cell ◽  
Future Challenges ◽  
On Chip

Cell-based approaches in medicine, biotechnology and in pharmaceutical research offer unique prospects to cope with future challenges in the field of public health. Stem cell research, autologous cell therapies and tissue engineering are only a few possible key applications. Progress in these fields will depend on the successful implementation of versatile and flexible tools for the gentle manipulation and characterization of cells. In recent years, we and others have introduced microfluidic lab-on-chip systems that include dielectrophoretic elements for the contact-less handling and the analysis of cells. Here, we present results that were obtained by combining our labon-on-chip devices with a low-cost centrifugation stage for the efficient and gentle separation of microparticles and live human cells. Our approach is supposed to overcome limitations that arise from the use of bulky and expensive external pumping stages.

scholarly journals Advances in Computational Fluid Mechanics in Cellular Flow Manipulation: A Review

2019 ◽  
Vol 9 (19) ◽  
pp. 4041 ◽  
Author(s):  
Masoud Arabghahestani ◽  
Sadegh Poozesh ◽  
Nelson K. Akafuah
Keyword(s):  
Numerical Simulations ◽  
Biological Effects ◽  
Single Cells ◽  
Computational Fluid Mechanics ◽  
Lab On Chip ◽  
Simulation Techniques ◽  
Flow Manipulation ◽  
Cellular Microenvironments ◽  
On Chip

Recently, remarkable developments have taken place, leading to significant improvements in microfluidic methods to capture subtle biological effects down to single cells. As microfluidic devices are getting sophisticated, design optimization through experimentations is becoming more challenging. As a result, numerical simulations have contributed to this trend by offering a better understanding of cellular microenvironments hydrodynamics and optimizing the functionality of the current/emerging designs. The need for new marketable designs with advantageous hydrodynamics invokes easier access to efficient as well as time-conservative numerical simulations to provide screening over cellular microenvironments, and to emulate physiological conditions with high accuracy. Therefore, an excerpt overview on how each numerical methodology and associated handling software works, and how they differ in handling underlying hydrodynamic of lab-on-chip microfluidic is crucial. These numerical means rely on molecular and continuum levels of numerical simulations. The current review aims to serve as a guideline for researchers in this area by presenting a comprehensive characterization of various relevant simulation techniques.

scholarly journals The Fusion of Microfluidics and Optics for On-Chip Detection and Characterization of Microalgae

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1137
Author(s):  
Xinqi Zheng ◽  
Xiudong Duan ◽  
Xin Tu ◽  
Shulan Jiang ◽  
Chaolong Song
Keyword(s):  
Fossil Fuels ◽  
High Specificity ◽  
Microfluidic Chips ◽  
Optical Components ◽  
Lab On Chip ◽  
Metabolic Heterogeneity ◽  
On Chip ◽  
Micro Systems

It has been demonstrated that microalgae play an important role in the food, agriculture and medicine industries. Additionally, the identification and counting of the microalgae are also a critical step in evaluating water quality, and some lipid-rich microalgae species even have the potential to be an alternative to fossil fuels. However, current technologies for the detection and analysis of microalgae are costly, labor-intensive, time-consuming and throughput limited. In the past few years, microfluidic chips integrating optical components have emerged as powerful tools that can be used for the analysis of microalgae with high specificity, sensitivity and throughput. In this paper, we review recent optofluidic lab-on-chip systems and techniques used for microalgal detection and characterization. We introduce three optofluidic technologies that are based on fluorescence, Raman spectroscopy and imaging-based flow cytometry, each of which can achieve the determination of cell viability, lipid content, metabolic heterogeneity and counting. We analyze and summarize the merits and drawbacks of these micro-systems and conclude the direction of the future development of the optofluidic platforms applied in microalgal research.

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