Scaffold-based articular cartilage repair - Future prospects wedding gene therapy and tissue engineering

2003 ◽  
Vol 22 (5) ◽  
pp. 42-50 ◽  
Author(s):  
R.M. Capito ◽  
M. Spector
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Future Prospects ◽  
Articular Cartilage Repair

Functional Tissue Engineering in Articular Cartilage Repair: Is There a Role for Electromagnetic Biophysical Stimulation?

2013 ◽  
Vol 19 (4) ◽  
pp. 353-367 ◽  
Author(s):  
Milena Fini ◽  
Stefania Pagani ◽  
Gianluca Giavaresi ◽  
Monica De Mattei ◽  
Alessia Ongaro ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Functional Tissue Engineering ◽  
Functional Tissue

Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells

2003 ◽  
Vol 48 (2) ◽  
pp. 430-441 ◽  
Author(s):  
Kolja Gelse ◽  
Klaus von der Mark ◽  
Thomas Aigner ◽  
Jung Park ◽  
Holm Schneider
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Repair ◽  
Mesenchymal Cells ◽  
Articular Cartilage Repair

scholarly journals Characterization of chondrocyte scaffold carriers for cell-based gene therapy in articular cartilage repair

2013 ◽  
Vol 101 (12) ◽  
pp. 3542-3550 ◽  
Author(s):  
Wei Shui ◽  
Liangjun Yin ◽  
Jeffrey Luo ◽  
Ruidong Li ◽  
Wenwen Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair

Cell-derived decellularized extracellular matrix scaffolds for articular cartilage repair

2020 ◽  
pp. 039139882095386
Author(s):  
Wenrun Zhu ◽  
Lu Cao ◽  
Chunfeng Song ◽  
Zhiying Pang ◽  
Haochen Jiang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Cell Attachment ◽  
Tissue Growth ◽  
Bioactive Molecules ◽  
Cartilage Tissue ◽  
Articular Cartilage Repair ◽  
Decellularized Extracellular Matrix

Articular cartilage repair remains a great clinical challenge. Tissue engineering approaches based on decellularized extracellular matrix (dECM) scaffolds show promise for facilitating articular cartilage repair. Traditional regenerative approaches currently used in clinical practice, such as microfracture, mosaicplasty, and autologous chondrocyte implantation, can improve cartilage repair and show therapeutic effect to some degree; however, the long-term curative effect is suboptimal. As dECM prepared by proper decellularization procedures is a biodegradable material, which provides space for regeneration tissue growth, possesses low immunogenicity, and retains most of its bioactive molecules that maintain tissue homeostasis and facilitate tissue repair, dECM scaffolds may provide a biomimetic microenvironment promoting cell attachment, proliferation, and chondrogenic differentiation. Currently, cell-derived dECM scaffolds have become a research hotspot in the field of cartilage tissue engineering, as ECM derived from cells cultured in vitro has many advantages compared with native cartilage ECM. This review describes cell types used to secrete ECM, methods of inducing cells to secrete cartilage-like ECM and decellularization methods to prepare cell-derived dECM. The potential mechanism of dECM scaffolds on cartilage repair, methods for improving the mechanical strength of cell-derived dECM scaffolds, and future perspectives on cell-derived dECM scaffolds are also discussed in this review.

Articular cartilage repair using allogeneic perichondrocyteseeded biodegradable porous polylactic acid (PLA): A tissue-engineering study

1995 ◽  
Vol 29 (9) ◽  
pp. 1147-1154 ◽  
Author(s):  
Constance R. Chu ◽  
Richard D. Coutts ◽  
Makoto Yoshioka ◽  
Frederick L. Harwood ◽  
Anna Z. Monosov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Polylactic Acid ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Engineering Study

Gene Therapy in Articular Cartilage Repair

2013 ◽  
pp. 21-41
Author(s):  
Alan Ivkovic ◽  
Andreja Vukasovic ◽  
Ryan M. Porter ◽  
Damir Hudetz ◽  
Marko Pecina ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair

Donor Cell Fate in Tissue Engineering for Articular Cartilage Repair

2001 ◽  
Vol 389 ◽  
pp. 228-237 ◽  
Author(s):  
Roger V. Ostrander ◽  
Randal S. Goomer ◽  
William L. Tontz ◽  
Monti Khatod ◽  
Frederick L. Harwood ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Articular Cartilage ◽  
Cell Fate ◽  
Cartilage Repair ◽  
Donor Cell ◽  
Articular Cartilage Repair
Sign in / Sign up

Export Citation Format

Share Document