Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells

2003 ◽  
Vol 48 (2) ◽  
pp. 430-441 ◽  
Author(s):  
Kolja Gelse ◽  
Klaus von der Mark ◽  
Thomas Aigner ◽  
Jung Park ◽  
Holm Schneider
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Repair ◽  
Mesenchymal Cells ◽  
Articular Cartilage Repair

Articular cartilage repair with autologous bone marrow mesenchymal cells

2010 ◽  
Vol 225 (2) ◽  
pp. 291-295 ◽  
Author(s):  
Tomiya Matsumoto ◽  
Takahiro Okabe ◽  
Tesshu Ikawa ◽  
Takahiro Iida ◽  
Hiroyuki Yasuda ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Autologous Bone Marrow ◽  
Mesenchymal Cells ◽  
Articular Cartilage Repair ◽  
Autologous Bone ◽  
Bone Marrow Mesenchymal Cells

scholarly journals Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Caining Wen ◽  
Limei Xu ◽  
Xiao Xu ◽  
Daping Wang ◽  
Yujie Liang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Repair ◽  
Critical Issue ◽  
Delivery Systems ◽  
Chondrocyte Apoptosis ◽  
Insulin Like Growth Factor ◽  
Articular Cartilage Repair ◽  
Osteoarthritis Treatment

AbstractArticular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.

scholarly journals Characterization of chondrocyte scaffold carriers for cell-based gene therapy in articular cartilage repair

2013 ◽  
Vol 101 (12) ◽  
pp. 3542-3550 ◽  
Author(s):  
Wei Shui ◽  
Liangjun Yin ◽  
Jeffrey Luo ◽  
Ruidong Li ◽  
Wenwen Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair

Gene Therapy in Articular Cartilage Repair

2013 ◽  
pp. 21-41
Author(s):  
Alan Ivkovic ◽  
Andreja Vukasovic ◽  
Ryan M. Porter ◽  
Damir Hudetz ◽  
Marko Pecina ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Articular Cartilage Repair
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