Research on a correlation between Cox-2 protein expression and the resistance of radiation therapy in esophageal squamous cell carcinoma

2011 ◽  
Author(s):  
Hui Wu ◽  
Qing-xia Fan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox 2

scholarly journals Targeting valosin‐containing protein enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma

2019 ◽  
Vol 110 (11) ◽  
pp. 3464-3475 ◽  
Author(s):  
Hui Luo ◽  
Hengli Song ◽  
Ronghu Mao ◽  
Qiang Gao ◽  
Zhuo Feng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma

2019 ◽  
Vol Volume 12 ◽  
pp. 1917-1927 ◽  
Author(s):  
Hui Qin ◽  
Yunyun Li ◽  
Hongyan Zhang ◽  
Feng Wang ◽  
Hong-liu He ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Implications

Effective combinations of radiotherapy and immunotherapy in the treatment of esophageal squamous cell carcinoma

2020 ◽  
Vol 16 (31) ◽  
pp. 2537-2549
Author(s):  
Yang Yang ◽  
Hong Ge
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Recurrence Risk ◽  
Systemic Treatments ◽  
Clinical Benefits ◽  
Pros And Cons

The traditional treatments for esophageal squamous cell carcinoma include surgery and radiation as local therapies, then chemotherapy and targeted therapy as systemic treatments. These treatments, either alone or in combination, however, are not satisfactory because of limited efficacy and unfavorable toxicity, calling for new therapeutic strategies. In recent years, immunotherapy, a new weapon in the arsenal against cancer, has shown substantial clinical benefits in patients with esophageal squamous cell carcinoma, particularly ones with locally advanced or metastatic disease. Importantly, accumulating evidence suggests that traditional radiation therapy functions as a powerful adjuvant for immunotherapy by contributing to systemic antitumor immunity, resulting in reduced recurrence risk and improved survival of patients. Here the authors summarize the emerging data on immunotherapy- and radiation therapy-based treatment of esophageal squamous cell carcinoma and discuss the pros and cons of different combinations, aiming at a comprehensive understanding of the proper rationale for the design of effective therapeutic regimens.

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