14-3-3ζ promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-κB signaling

2018 ◽  
Vol 643 ◽  
pp. 7-13 ◽  
Author(s):  
Song Tong ◽  
Sheng-Cai Chen ◽  
Kai-Ying Xu ◽  
Bin Fang ◽  
Si-Hua Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma

2019 ◽  
Vol Volume 12 ◽  
pp. 1917-1927 ◽  
Author(s):  
Hui Qin ◽  
Yunyun Li ◽  
Hongyan Zhang ◽  
Feng Wang ◽  
Hong-liu He ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Implications

scholarly journals p16 INK4a hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Noushin Taghavi ◽  
Firouzeh Biramijamal ◽  
Masoud Sotoudeh ◽  
Hooman Khademi ◽  
Reza Malekzadeh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mdm2 Protein ◽  
P16 Ink4a

scholarly journals Association between TP53 gene deletion and protein expression in esophageal squamous cell carcinoma and its prognostic significance

2020 ◽  
Vol 20 (2) ◽  
pp. 1855-1865
Author(s):  
Madiniyet Niyaz ◽  
Julaiti Ainiwaer ◽  
Abulajiang Abudureheman ◽  
Liwei Zhang ◽  
Ilyar Sheyhidin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Gene Deletion ◽  
Prognostic Significance ◽  
Tp53 Gene

PS02.051: HMGB IS INVOLVED IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA PROGRESSION

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 134-135
Author(s):  
Daiki Matsubara ◽  
Hirotaka Konishi ◽  
Katsutoshi Shoda ◽  
Tomohiro Arita ◽  
Toshiyuki Kosuga ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Protein Expression ◽  
Healthy Volunteers ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Squamous Cell ◽  
Plasma Samples ◽  
Tissue Samples ◽  
Mrna And Protein Expression

Abstract Background High-mobility group box-1 (HMGB1), originally characterized as a non-histone, nuclear DNA-binding protein, acts as a crucial proinflammatory cytokine, mediating a broad range of inflammatory responses as a secretory form. Recently, it has been reported to be involved in the tumorigenesis and progression of various types of malignancies, but it is unclear whether HMGB1 plays an important role in the progression of esophageal squamous cell carcinoma (ESCC). The aim of this study was to investigate the significance of HMGB1 in ESCC. Methods The tissue and plasma samples were obtained from ESCC patients at before or after operative period and healthy volunteers. The ESCC cell lines and normal human cell lines, such as fibroblast (WI-38) or Human umbilical vein endothelial cell (HUVEC), were used in vitro analyses. The expression levels of HMGB1 in tissue samples were measured by quantitative RT-PCR. The protein levels of HMGB1 were measured using the HMGB1 enzyme-linked immunosorbent assay kit in plasma samples, and using immunohistochemical staining or western blotting in tissue samples or cell lines. The functions of HMGB1 on the ESCC cell lines were investigated by proliferation, invasion, or migration assays. Results The mRNA and protein expression of HMGB1 in ESCC tissue was significantly higher than that in paired non-cancerous esophageal mucosa tissue. Plasma HMGB1 level was slightly higher, but not significant, in ESCC patients than in healthy volunteers. However, it was significantly higher in ESCC patients with Neoadjuvant chemotherapy (NAC) than in those without NAC. The mRNA and protein expression of HMGB1 were higher in ESCC cell lines than in WI-38 or HUVEC. In ESCC cells with high HMGB1 expression, knockdown of HMGB1 using specific siRNAs inhibited the cell proliferation, migration and invasion. Conclusion These findings suggest that HMGB1 plays a crucial role in tumor malignant potential through its overexpression in esophageal squamous cell carcinoma. Disclosure All authors have declared no conflicts of interest.

Sign in / Sign up

Export Citation Format

Share Document