Efficient synonym filtering and scalable delayed translation for hybrid virtual caching

2016 ◽  
Author(s):  
Chang Hyun Park ◽  
Taekyung Heo ◽  
Jaehyuk Huh
Keyword(s):  
Delayed Translation

Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development

1989 ◽  
Vol 9 (12) ◽  
pp. 5395-5403
Author(s):  
M Gusse ◽  
J Ghysdael ◽  
G Evan ◽  
T Soussi ◽  
M Méchali
Keyword(s):  
Embryonic Development ◽  
Xenopus Laevis ◽  
Protein Content ◽  
Mature Oocyte ◽  
Gastrula Stage ◽  
Cleavage Stage ◽  
Midblastula Transition ◽  
Phosphorylation State ◽  
Growing Cell ◽  
Delayed Translation

The c-myc proto-oncogene is expressed as a maternal protein during oogenesis in Xenopus laevis, namely, in nondividing cells. A delayed translation of c-myc mRNA accumulated in early oocytes results in the accumulation of the protein during late oogenesis. The oocyte c-myc protein is unusually stable and is located in the cytoplasm, contrasting with its features in somatic cells. A mature oocyte contains a maternal c-myc protein stockpile of 4 x 10(5) to 6 x 10(5) times the level in a somatic growing cell. This level of c-myc protein is preserved only during the cleavage stage of the embryo. Fertilization triggers its rapid migration into the nuclei of the cleaving embryo and a change in the phosphorylation state of the protein. The c-myc protein content per nucleus decreases exponentially during the cleavage stage until a stoichiometric titration by the embryonic nuclei is reached during a 0.5-h period at the midblastula stage. Most of the maternal c-myc store is degraded by the gastrula stage. These observations implicate the participation of c-myc in the events linked to early embryonic development and the midblastula transition.

scholarly journals Using the SCAMPER Model to DevelopTranslation Skills for Major Students in the Faculty of Education, Majmaah University, Saudi Arabia

2019 ◽  
Author(s):  
AWEJ-tls for Translation & Literary Studies ◽  
Fatma Farid Fakhry Tharwa
Keyword(s):  
Saudi Arabia ◽  
Foreign Language ◽  
English Language ◽  
Language Translation ◽  
Teaching English ◽  
School Year ◽  
Delayed Translation ◽  
Students Attitudes ◽  
Faculty Of Education ◽  
Experimental Group

This paper aims at identifying the effectiveness of using the SCAMPER model in developing translation and raising the attitudes towards adaptation among major students in the faculty of education, Majmaah University, Saudi Arabia. It tries to answer the following questions: To what extent would using the SCAMPER model raise translation skills among major students in the faculty of education – Majmaah University .the the second question is To what extent would using SCAMPER model raise the attitudes towards translation among major students.To accomplish the purpose of the study, the researcher showed the experimental group with a sample involved (40) students for the SCAMPER Model in the first term of the school year 2018-2019. The researcher used (pre -post & delayed) translation test, a scale of students' attitudes towards translation to collect data. The study's results suggested that there were statistically important differences at (α ≤ 0.05) in the whole mean grade in the pre post translation test to the group in favor of posttest. Also, there were statistically important differences at (α ≤ 0.05) in the whole mean grade in the pre-post scale of students attitudes towards translation to the group in favor of post implication. Also, the researcher recognized these differences in using the SCAMPER Model in teaching English language translation. In light of these outcomes, the study suggested the necessity of applying the SCAMPER Model in teaching the English language to get better results in students’ translation learning and retention in English as a foreign language. Similarly, the SCAMPER Model would be used with other English skills and sub-skills.

Delayed Translation of Spermatid-Specific mRNAs Is Mediated by the microRNA Pathway.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 166-166
Author(s):  
Rui Song ◽  
Jiachen Li ◽  
Qiuxia Wu ◽  
Huili Zheng ◽  
John R. McCarrey ◽  
...  
Keyword(s):  
Delayed Translation ◽  
Specific Mrnas ◽  
Microrna Pathway

scholarly journals Limitations and Flaws of Preclinical Pulmonary Hypertension Studies

2020 ◽  
Vol 19 (2) ◽  
pp. 47-54
Author(s):  
Tsukasa Shimauchi ◽  
François Potus ◽  
Sébastien Bonnet ◽  
Steeve Provencher ◽  
Roxane Paulin ◽  
...  
Keyword(s):  
Animal Ethics ◽  
Preclinical Studies ◽  
Preclinical Research ◽  
Funding Agencies ◽  
Need Support ◽  
Innovative Therapies ◽  
Peer Reviewers ◽  
Delayed Translation ◽  
Rigorous Study ◽  
Pulmonary Arterial

Despite advances in our understanding of the disease, significant therapeutic gaps remain for pulmonary arterial hypertension (PAH). Indeed, no cure exists yet for this devastating disease, and very few innovative therapies beyond the traditional pathways of endothelial dysfunction have reached late clinical trial phases in PAH. While there are inherent limitations to the currently available animal models of PAH, the delayed translation of innovative therapies to the clinic may also relate to flawed preclinical research methodologies. The present article discusses the limitations and flaws in the design of preclinical PH trials and discusses opportunities to create preclinical studies with improved predictive value in identifying key mechanisms involved in PAH development and progression and guiding early phase drug development in PAH patients. The implementation of rigorous study design will need support not only from researchers, peer reviewers, and editors, but also from academic institutions, funding agencies, and animal ethics authorities.

scholarly journals miRNA-dependent poly(A) length control in uncoupling transcription and translation of haploid male germ cells

2021 ◽  
Author(s):  
Chong Tang ◽  
Mei Guo ◽  
Zhuoxing Shi ◽  
Zhuqing Wang ◽  
Chunhai Luo ◽  
...  
Keyword(s):  
Germ Cells ◽  
Regulatory Mechanisms ◽  
Translational Repression ◽  
Dynamic Changes ◽  
Male Germ Cells ◽  
Haploid Male ◽  
Transcriptional Regulatory ◽  
Delayed Translation ◽  
Transcriptional Regulatory Mechanisms

AbstractAs one of the post-transcriptional regulatory mechanisms, transcription and translation’s uncoupling plays an essential role in development and adulthood physiology. However, it remains elusive how thousands of mRNAs get translationally silenced while stability is maintained for up to hours or even days before translation. In addition to oocytes and neurons, developing spermatids have significant uncoupling of transcription and translation for delayed translation. Therefore, spermiogenesis represents an excellent in vivo model for investigating the mechanism underlying uncoupled transcription and translation. Through full-length poly(A) deep sequencing, we discovered dynamic changes in poly(A) length through deadenylation and re-polyadenylation. Deadenylation appeared to be mediated by microRNAs (miRNAs), and transcripts with shorter poly(A) tails tend to be sequestered into ribonucleoproteins (RNPs) for translational repression and stabilization. In contrast, re-polyadenylation allows for translocation of the translationally repressed transcripts from RNPs to polysomes for translation. Overall, our data suggest that miRNA-dependent poly(A) length control represents a novel mechanism underlying uncoupled translation and transcription in haploid male germ cells.

scholarly journals Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development.

1989 ◽  
Vol 9 (12) ◽  
pp. 5395-5403 ◽  
Author(s):  
M Gusse ◽  
J Ghysdael ◽  
G Evan ◽  
T Soussi ◽  
M Méchali
Keyword(s):  
Embryonic Development ◽  
Xenopus Laevis ◽  
Protein Content ◽  
Mature Oocyte ◽  
Gastrula Stage ◽  
Cleavage Stage ◽  
Midblastula Transition ◽  
Phosphorylation State ◽  
Growing Cell ◽  
Delayed Translation

The c-myc proto-oncogene is expressed as a maternal protein during oogenesis in Xenopus laevis, namely, in nondividing cells. A delayed translation of c-myc mRNA accumulated in early oocytes results in the accumulation of the protein during late oogenesis. The oocyte c-myc protein is unusually stable and is located in the cytoplasm, contrasting with its features in somatic cells. A mature oocyte contains a maternal c-myc protein stockpile of 4 x 10(5) to 6 x 10(5) times the level in a somatic growing cell. This level of c-myc protein is preserved only during the cleavage stage of the embryo. Fertilization triggers its rapid migration into the nuclei of the cleaving embryo and a change in the phosphorylation state of the protein. The c-myc protein content per nucleus decreases exponentially during the cleavage stage until a stoichiometric titration by the embryonic nuclei is reached during a 0.5-h period at the midblastula stage. Most of the maternal c-myc store is degraded by the gastrula stage. These observations implicate the participation of c-myc in the events linked to early embryonic development and the midblastula transition.

Efficient synonym filtering and scalable delayed translation for hybrid virtual caching

2016 ◽  
Vol 44 (3) ◽  
pp. 217-229 ◽  
Author(s):  
Chang Hyun Park ◽  
Taekyung Heo ◽  
Jaehyuk Huh
Keyword(s):  
Delayed Translation

scholarly journals Jak twórczość mistrza polskiego reportażu stała się „peryferyjną”? O recepcji Jeszcze dzień życia R. Kapuścińskiego w kulturze macedońskiej

2019 ◽  
Vol 9 (3) ◽  
pp. 123-133
Author(s):  
Lidija Tanuševska
Keyword(s):  
Literary Genre ◽  
The Social ◽  
Delayed Translation ◽  
The Way

This article is about the reception of Kapuściński’s book Another Day of Life which was translated and published in Macedonia in 2017. This text explains the reasons of the delayed translation of Kapuściński’s book and the social environmentsurrounding its reception, as well as the reception of the reportage as a literary genre in Macedonia. Those are part of the reasons why this literary master has passed by almost unnoticed in this culture and his works are pushed aside from the main literary streams. The article also deals with translating problems concerning the alienation / otherness and the way foreign realities are transferred from Polish to Macedonian language.

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