Multimode Interference Waveguide-Based 7× Multiplexed Detection of Nucleic Acids for Antibiotic-Resistant Bacterial Screening

2018 ◽  
Author(s):  
G. G. Meena ◽  
M. A. Stott ◽  
O. Brown ◽  
R. Robison ◽  
A. R. Hawkins ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Multimode Interference ◽  
Antibiotic Resistant ◽  
Multiplexed Detection ◽  
Bacterial Screening

Multiplexed Detection of Attomoles of Nucleic Acids Using Fluorescent Nanoparticle Counting Platform

2018 ◽  
Vol 90 (2) ◽  
pp. 1376-1383 ◽  
Author(s):  
Xiaojing Pei ◽  
Haoyan Yin ◽  
Tiancheng Lai ◽  
Junlong Zhang ◽  
Feng Liu ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Multiplexed Detection ◽  
Fluorescent Nanoparticle

scholarly journals Simultaneous detection of small molecules, proteins and microRNAs using single molecule arrays

2020 ◽  
Vol 11 (30) ◽  
pp. 7896-7903 ◽  
Author(s):  
Xu Wang ◽  
David R. Walt
Keyword(s):  
Nucleic Acids ◽  
Small Molecules ◽  
Single Molecule ◽  
Simultaneous Detection ◽  
Multiplexed Detection ◽  
Measurement Methodology

The first example of multiplexed detection of proteins, nucleic acids, and small molecules using single molecule measurement methodology.

Multiplexed detection of nucleic acids in a combinatorial screening chip

Lab on a Chip ◽  
2011 ◽  
Vol 11 (11) ◽  
pp. 1916 ◽  
Author(s):  
Benjamin R. Schudel ◽  
Melikhan Tanyeri ◽  
Arnab Mukherjee ◽  
Charles M. Schroeder ◽  
Paul J. A. Kenis
Keyword(s):  
Nucleic Acids ◽  
Combinatorial Screening ◽  
Multiplexed Detection

scholarly journals Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics

2013 ◽  
Vol 57 (9) ◽  
pp. 4575-4577 ◽  
Author(s):  
Yang Mu ◽  
Zhangqi Shen ◽  
Byeonghwa Jeon ◽  
Lei Dai ◽  
Qijing Zhang
Keyword(s):  
Synergistic Effect ◽  
Nucleic Acids ◽  
Campylobacter Jejuni ◽  
Efflux Pump ◽  
Peptide Nucleic Acids ◽  
Synergistic Effects ◽  
Antibiotic Resistant ◽  
Content Type ◽  
Promising Strategy ◽  
Antisense Peptide

ABSTRACTThe CmeABC efflux pump inCampylobacter jejuniconfers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistantCampylobacter. Antisense peptide nucleic acids (PNAs) targeting the three components of CmeABC were evaluated for inhibition of CmeABC expression. The result revealed a synergistic effect of the PNAs targeting CmeA and CmeB on sensitizingC. jejunito antibiotics. This finding further demonstrates the feasibility of using PNAs to potentiate antibiotics against antibiotic-resistantCampylobacter.

Multiplexed detection of nucleic acids using 19F NMR chemical shift changes based on DNA photo-cross-linking of 3-vinylcarbazole derivatives

2018 ◽  
Vol 16 (6) ◽  
pp. 891-894
Author(s):  
Shigetaka Nakamura ◽  
Yasuharu Takashima ◽  
Kenzo Fujimoto
Keyword(s):  
Chemical Shift ◽  
Nucleic Acids ◽  
19F Nmr ◽  
Cross Linking ◽  
Nmr Chemical Shift ◽  
Multiplexed Detection

The 19F NMR identical to trifluorothymidine was large shifted by DNA photo-cross-linking. The shifted signal dispersion was induced by the substituent of 3-vinylcarbazole derivatives.

scholarly journals 3× multiplexed detection of antibiotic resistant plasmids with single molecule sensitivity

Lab on a Chip ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 3763-3771 ◽  
Author(s):  
G. G. Meena ◽  
R. L. Hanson ◽  
R. L. Wood ◽  
O. T. Brown ◽  
M. A. Stott ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Single Molecule ◽  
Antibiotic Resistant ◽  
Multiplexed Detection ◽  
Resistance Plasmids ◽  
Carbapenem Antibiotic

This work presents a rapid sample-to-answer system enabling multiplexed detection of three carbapenem antibiotic resistance plasmids with single molecule sensitivity.

Antisense agents against antibiotic-resistant bacteria

2022 ◽  
Vol 23 ◽  
Author(s):  
Javad Nezhadi ◽  
Sepehr Taghizadeh ◽  
Ehsaneh Khodadadi ◽  
Mehdi Yousefi ◽  
Khudaverdi Ganbarov ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Nucleic Acids ◽  
Bacterial Species ◽  
Antibacterial Properties ◽  
Resistant Bacteria ◽  
Antibiotic Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Pharmacokinetic Properties ◽  
A New Technique ◽  
New Perspective

Abstract: The dramatically increasing levels of antibiotic resistance are being seen worldwide, and is a significant threat to public health. Antibiotic and drug resistance is seen in various bacterial species. Antibiotic resistance is associated with increased morbidity and mortality and increased treatment costs. Antisense-relevant technologies include the utilization of oligonucleotide molecules to interfere with gene expression, as a new technique for the treatment of antibiotic-resistant bacteria has been proposed antisense agents or nucleic acids analogs with antibacterial properties, which are commonly very short and their size almost 10-20 bases and can be hinted to peptide nucleic acids (PNAs), phosphorodiamidate morpholino oligomers (PPMOs) and locked nucleic acids (LNAs). This review highlights that PNAs, PPMOs, and LNAs target the genes that cause destroy the gene and inhibit the growth of bacteria. These results open a new perspective for therapeutic intervention. In future studies, it is necessary to examine different aspects of antisense agents, for example, safety, toxicity, and pharmacokinetic properties of antisense agents to be employed in clinical treatment.

scholarly journals 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening

2020 ◽  
Vol 28 (22) ◽  
pp. 33019
Author(s):  
G. G. Meena ◽  
T. A. Wall ◽  
M. A. Stott ◽  
O. Brown ◽  
R. Robison ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Nucleic Acids ◽  
Bacterial Screening

Electron Microscopy of Nucleic Acids

1974 ◽  
Vol 32 ◽  
pp. 302-303
Author(s):  
Norman Davidson
Keyword(s):  
Electron Microscopy ◽  
Nucleic Acids ◽  
Basic Protein ◽  
Molecular Biologist ◽  
Topological Properties ◽  
Protein Film ◽  
Polynucleotide Chain

The basic protein film technique for mounting nucleic acids for electron microscopy has proven to be a general and powerful tool for the working molecular biologist in characterizing different nucleic acids. It i s possible to measure molecular lengths of duplex and single-stranded DNAs and RNAs. In particular, it is thus possible to as certain whether or not the nucleic acids extracted from a particular source are or are not homogeneous in length. The topological properties of the polynucleotide chain (linear or circular, relaxed or supercoiled circles, interlocked circles, etc. ) can also be as certained.

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