Magnetosensitive lipid composites encapsulated by cytostatic agent. preparation, sterilization conditions, properties

2012 ◽  
Author(s):  
Taisiya Fedushchyak ◽  
Sergey Antipov ◽  
Igor Khlusov ◽  
Mihail Uimin ◽  
Vladislav Rostov ◽  
...  
Keyword(s):  
Cytostatic Agent

ANTIBODY-DRUG CONJUGATES FOR TARGETED CANCER THERAPY

2019 ◽  
Vol 65 (6) ◽  
pp. 777-784
Author(s):  
David Korman
Keyword(s):  
Clinical Trials ◽  
Clinical Practice ◽  
Gemtuzumab Ozogamicin ◽  
Brentuximab Vedotin ◽  
Cytostatic Agent ◽  
Cytostatic Agents ◽  
Drug Conjugates ◽  
Natural Substances ◽  
Intracellular Release ◽  
High Antitumor Activity

Monoclonal antibody (MAB) conjugates with cytostatic agents (ADC) are intended for selective delivery of a cytostatic agent to a tumor cell. Three ADC have been approved for clinical use (gemtuzumab ozogamicin, brentuximab vedotin, trastuzumab-DM1); a few dozens of other ADC are undergoing clinical trials. Several derivatives of natural substances (antibiotics and inhibitors of microtubules) having a high antitumor activity are used as cytostatic agents included in ADC. They are inapplicable in clinical practice as self-sustained drugs due to their considerable toxicity. Of great importance for the implementation of the ADC effect is the character of a linker connecting MAB with a cytostatic agent and ensuring selective intracellular release after ADC internalization. The structure, mechanisms of action, and the results of clinical trials of a number of ADC are considered here as an illustration (by way of example). The development of ADC can help introduce new effective cytostatic agents into clinical practice.

Drug-specific /sup 19/F NMR and dynamic /sup 18/F PET imaging of the cytostatic agent 5-fluorouracil

1994 ◽  
Vol 41 (6) ◽  
pp. 2856-2861 ◽  
Author(s):  
M.E. Bellemann ◽  
G. Brix ◽  
U. Haberkorn ◽  
H.J. Ostertag ◽  
W.J. Lorenz
Keyword(s):  
Pet Imaging ◽  
Cytostatic Agent ◽  
19 F Nmr

Virazole (Ribavirin) a Cytostatic Agent

1978 ◽  
pp. 7-7
Author(s):  
J. Arendes ◽  
R. K. Zahn ◽  
W. E. G. Müller
Keyword(s):  
Cytostatic Agent

1,6-Di-(2-Bromoethylamino)-1,6-Dideoxy-D-Mannitol Dihydrobromide: a New Cytostatic Agent

Nature ◽  
1959 ◽  
Vol 183 (4658) ◽  
pp. 394-395 ◽  
Author(s):  
L. VARGHA ◽  
T. HORVÁTH
Keyword(s):  
Cytostatic Agent

Microwave-Induced Hyperthermia and Cytostatic Agent for Superficial Bladder Cancer

2005 ◽  
Vol 72 (4) ◽  
pp. 443-445
Author(s):  
A. Ruggirello ◽  
V. Serretta ◽  
A. Galuffo ◽  
M. Vella ◽  
C. Pavone ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Superficial Bladder Cancer ◽  
Randomized Study ◽  
Bladder Wall ◽  
Treatment Interruption ◽  
Thermal Reaction ◽  
Cytostatic Agent ◽  
Induced Hyperthermia ◽  
Local Toxicity ◽  
Significant Difference

The efficacy and local toxicity of the intravesical combination of microwave-induced hyperthermia with a cytostatic agent in patients affected by superficial bladder cancer is presented. Between 1994 and 2002, two studies were performed on ablative and adjuvant intravesical thermo-chemotherapy. The ablative study demonstrated complete tumor eradication in 88% of patients who should have undergone cystectomy due to diffuse multiple papillary tumors non-responsive TUR and intravescical adjuvant therapy. In a randomized study, comparing adjuvant thermo-chemotherapy vs. standard chemotherapy with mitomycin C, recurrence-free survival analysis at 24 months revealed a significant difference in favor of thermo-chemotherapy. Our preliminary experience confirmed that local side effects, mainly cystitis, suprapubic pain and thermal reaction of the posterior bladder wall, were transitory and did not require treatment interruption.

Alpha-Fetoprotein Response in Advanced Hepatocellular Carcinoma Receiving Cytostatic Agent

2009 ◽  
Vol 27 (36) ◽  
pp. e271-e271 ◽  
Author(s):  
Li-Tzong Chen ◽  
Her-Shyong Shiah ◽  
Yee Chao ◽  
Jang-Yang Chang ◽  
Li-Ting Cheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Alpha Fetoprotein ◽  
Advanced Hepatocellular Carcinoma ◽  
Cytostatic Agent
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