Dynamic Contrast-Enhanced Magnetic Resonance Angiography of Gd-TTDA-BOM and Gd-DTPA at 3T in a Normal Rat Model

2012 ◽  
Author(s):  
Jo-Chi Jao ◽  
Yen-Ku Chen ◽  
Twei-Shiun Jaw ◽  
Yun-Ming Wang ◽  
Po-Chou Chen
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Rat Model ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Normal Rat

DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE ANGIOGRAPHY OF Gd-TTDA-BOM COMPARED WITH Gd-DTPA IN NORMAL RAT AT 3T

2014 ◽  
Vol 26 (02) ◽  
pp. 1450027
Author(s):  
Jo-Chi Jao ◽  
Yen-Ku Chen ◽  
Twei-Shiun Jaw ◽  
Yun-Ming Wang ◽  
Po-Chou Chen
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Vascular Diseases ◽  
Signal Enhancement ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Normal Rat ◽  
Reorientation Time ◽  
Phantom Studies

Dynamic contrast-enhanced magnetic resonance angiography (DCE-MRA) is a good modality for the diagnosis of vascular diseases. Contrast agents that produce higher and longer enhancement in vessels are highly valued. The complex of gadolinium with (R,S)-4-carboxy-5,9,12-tris(carboxymethyl)-l-phenyl-2-oxa-5,9,12-triazatridecan-14-oic acid (Gd-TTDA-BOM) possesses a benzyloxymethyl group in the ligand TTDA-BOM with the capability of raising lipophilicity. The Gd-TTDA-BOM complex expresses higher and longer enhancement in mouse liver than that of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) because of its faster water exchange rate, higher reorientation time, and higher lipophilicity. Phantom studies have shown that Gd-TTDA-BOM has expressed with higher affinity to human serum albumin (HSA) than Gd-DTPA. In general, these characteristics might provide an advantage for vascular imaging. To verify this in vivo, a 3T MR scanner was used to investigate the signal enhancement in the aorta of normal rats by DCE-MRA after the bolus injection of Gd-TTDA-BOM and compared this with the injection of Gd-DTPA. Gd-TTDA-BOM expressed higher and longer signal enhancement in the aorta than Gd-DTPA. These results suggest that Gd-TTDA-BOM could provide better image quality than Gd-DTPA as an enhancement agent in DCE-MRA.

Evaluation of Tumor Hypoxia in C6 Glioma Rat Model With Dynamic Contrast-Enhanced Magnetic Resonance Imaging

2019 ◽  
Vol 26 (8) ◽  
pp. e224-e232 ◽  
Author(s):  
Weishu Hou ◽  
Yangyang Xue ◽  
Wei Tang ◽  
Hongli Pan ◽  
Man Xu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rat Model ◽  
Tumor Hypoxia ◽  
C6 Glioma ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Dynamic Contrast-Enhanced Magnetic Resonance Angiography of the Thoracic Vessels

2010 ◽  
Vol 45 (11) ◽  
pp. 708-714 ◽  
Author(s):  
Katja Seng ◽  
Stefan Maderwald ◽  
Armin de Greiff ◽  
Harald H. Quick ◽  
Gerhard Laub ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

scholarly journals Improved dynamic contrast-enhanced magnetic resonance angiography (CE-MRA) using iterative data reconstruction

2016 ◽  
Vol 18 (S1) ◽  
Author(s):  
Luigia D'Errico ◽  
Michaela Schmidt ◽  
Jens Wetzl ◽  
Christoph Forman ◽  
Aurelien F Stalder ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Data Reconstruction ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
Sign in / Sign up

Export Citation Format

Share Document