Determining the difference in eyegaze measurements in individuals with Age related Macular Degeneration

PSS8 - IDENTIFYING THE CONFOUNDERS THAT EXPLAIN THE DIFFERENCE IN READOUTS BETWEEN NON-INTERVENTIONAL STUDIES (NIS) AND RANDOMIZED CONTROLLED TRIALS (RCTS): THE CASE OF TREATMENTS IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NAMD)

Value in Health ◽

10.1016/j.jval.2018.09.2508 ◽

2018 ◽

Vol 21 ◽

pp. S423 ◽

Cited By ~ 1

Author(s):

A. Sagkriotis ◽

R. Griner ◽

A. Durus ◽

O.M. Doyle ◽

L. Rodriguez Torres ◽

...

Keyword(s):

Randomized Controlled Trials ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Controlled Trials ◽

Randomized Controlled ◽

Age Related ◽

The Difference

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Visual acuity dynamics after phacoemulsification in patients with “wet” form of age-related macular degeneration, treated by intravitreal angiogenesis inhibitor injections

Ophthalmology journal ◽

10.17816/ov2013144-50 ◽

2013 ◽

Vol 6 (1) ◽

pp. 44-50 ◽

Cited By ~ 1

Author(s):

Natalya Viktorovna Chistyakova ◽

Yuriy Sergeevich Astakhov ◽

Nikita Yuryevich Dal

Keyword(s):

Visual Acuity ◽

Cataract Surgery ◽

Macular Degeneration ◽

Angiogenesis Inhibitor ◽

Age Related Macular Degeneration ◽

Age Related ◽

The Mean ◽

The Difference ◽

Group 2 ◽

Wet Amd

Design: prospective non-randomized experimental longitudinal cohort study. The aim of the study: to evaluate the visual acuity after phacoemulsification in patients with the “wet” form of age-related macular degeneration, treated by intravitreal angiogenesis inhibitor injections. Materials: 48 patients (48 eyes) with the “wet” form of AMD, treated by intravitreal angiogenesis inhibitor injections, and incipient cataract. All eyes in the study had a diagnosis of “wet” AMD and underwent cataract surgery. They were followed for a minimum of two years after the cataract surgery. The mean age of patients was 78.16 ± 5 years. There were 36 female (75 %) and 12 male (25 %) patients. Results: All patients were retrospectively divided into two groups. Group No. 1 consisted of 23 patients — operated within a year of the diagnosis of “wet” AMD, and group No. 2 which consisted of 25 patients who had a diagnosis of “wet” AMD for longer than one year prior to the cataract surgery. The mean preoperative visual acuity in the 1st group was 0.16 ± 0.07 (median 0.15), and in patients of group 2 — 0.23 ± 0.06 (median 0,2). Mean visual acuity immediately before surgery in the 1st group was 0.13 ± 0.04 (median 0.09), in the 2nd group — 0.12 ± 0.04 (median 0,08). After surgery, in the 1st group, mean visual acuity was — 0.28 ± 0.08 (median 0.25), in the 2nd group —0.18 ± 0.07 (median 0,15). The difference between the two groups was statistically significant, p < 0.01, t-test. Statistically significant visual acuity increase after surgery was registered in both groups and was preserved after one and two years, when compared to the data before surgery: for the 1st group — 0.13 and 0.1; for the 2nd group — 0,1 and 0.07, respectively (p < 0,01, Wilcoxon criterion). Conclusions: Phacoemulsification is reasonable for eyes with the “wet” form of age-related macular degeneration. Patients with shorter “wet” AMD duration obtain a higher visual acuity increase after cataract surgery. Statistically significant visual acuity increase after surgery is preserved in the majority of patients during next 2 years of follow-up.

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The Difference that Age Makes: Cultural Factors that Shape Older Adults’ Responses to Age-Related Macular Degeneration

Journal of Visual Impairment & Blindness ◽

10.1177/0145482x0810201002 ◽

2008 ◽

Vol 102 (10) ◽

pp. 581-590 ◽

Cited By ~ 7

Author(s):

Marja Mogk

Keyword(s):

Older Adults ◽

Macular Degeneration ◽

Vision Loss ◽

Cultural Factors ◽

Age Related Macular Degeneration ◽

Sociocultural Perspective ◽

Visual Rehabilitation ◽

Age Related ◽

Perceptions Of Aging ◽

The Difference

This article suggests that approaching vision loss from age-related macular degeneration from a sociocultural perspective, specifically considering perceptions of aging, blindness, disability, and generational viewpoints and norms, may be critical to understanding older adults’ responses to vision loss and visual rehabilitation.

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Periodontal Disease and Age-Related Macular Degeneration: A Meta-Analysis of 112,240 Participants

BioMed Research International ◽

10.1155/2020/4753645 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Xuewen Lv ◽

Weiqi Li ◽

Zhiyu Fang ◽

Xiaofei Xue ◽

Chunling Pan ◽

...

Keyword(s):

Periodontal Disease ◽

Macular Degeneration ◽

Data Extraction ◽

Meta Analysis ◽

Epidemiological Studies ◽

Age Related Macular Degeneration ◽

Cochrane Library ◽

Age Related ◽

The Difference ◽

Exact Relationship

Objective. Epidemiological studies have shown a correlation between periodontal disease (PD) and age-related macular degeneration (AMD). However, the results have been inconsistent, and no relevant meta-analysis has been performed on this topic. Hence, we performed a meta-analysis to evaluate whether the two diseases are related. Material and Methods. The PubMed, Embase, Cochrane Library, and Web of Science databases were searched up to April 20, 2020, for related articles. Two authors independently conducted literature screening and data extraction and then used the Stata 15.1 software to calculate the relative risk (RRs) and 95% confidence intervals (CIs) to assess the association between PD and AMD. Results. A total of 5 observational studies involving 112,240 participants and 5,005 AMD patients were included. The results of meta-analysis using the random-effects model showed that the incidence of AMD in PD patients was 1.35 times that of non-PD patients; the difference was statistically significant ( RR = 1.35 , 95 % CI = 1.07 – 1.70 , P = 0.011 ). Sensitivity analysis showed that the results were stable. Conclusions. PD patients have a higher risk of AMD, but the causal relationship between PD and AMD has not been confirmed. Further research should be carried out to verify the exact relationship between the two.

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Superoxide Dismutase1 Levels in North Indian Population with Age-Related Macular Degeneration

Oxidative Medicine and Cellular Longevity ◽

10.1155/2013/365046 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Akshay Anand ◽

Neel K. Sharma ◽

Amod Gupta ◽

Sudesh Prabhakar ◽

Suresh K. Sharma ◽

...

Keyword(s):

Oxidative Stress ◽

Logistic Regression ◽

Regression Model ◽

Macular Degeneration ◽

Roc Curve ◽

Goodness Of Fit ◽

Logistic Regression Model ◽

Age Related Macular Degeneration ◽

Age Related ◽

The Difference

Aim.The aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD.Methods.115 AMD patients and 61 healthy controls were recruited for this study. Serum SOD1 levels were determined by ELISA and were correlated to various risk factors. Logistic regression model of authenticity, by considering SOD1 as independent variable, has been developed along with ROC curve.Results.The SOD1 levels were significantly higher in AMD patients as compared to those of the controls. The difference was not significant for wet and dry AMD. However, the difference was significant between wet AMD subtypes. Nonsignificance of the Hosmer-Lemeshow goodness of fit statistic (χ2=10.516,df=8,P=0.231) indicates the appropriateness of logistic regression model to predict AMD.Conclusion.Oxidative stress in AMD patients may mount compensatory response resulting in increased levels of SOD1 in AMD patients. To predict the risk of AMD on the basis of SOD1, a logistic regression model shows authenticity of 78%, and area under the ROC curve (0.827,P=.0001) with less standard error of 0.033 coupled with 95% confidence interval of 0.762–0.891 further validates the model.

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Automated Segmentation Methods of Drusen to Diagnose Age-Related Macular Degeneration Screening in Retinal Images

Computational and Mathematical Methods in Medicine ◽

10.1155/2018/6084798 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Young Jae Kim ◽

Kwang Gi Kim

Keyword(s):

Macular Degeneration ◽

High Reliability ◽

Median Filter ◽

Age Related Macular Degeneration ◽

Optic Disk ◽

Fundus Image ◽

Difference Image ◽

Age Related ◽

Renyi’S Entropy ◽

The Difference

Existing drusen measurement is difficult to use in clinic because it requires a lot of time and effort for visual inspection. In order to resolve this problem, we propose an automatic drusen detection method to help clinical diagnosis of age-related macular degeneration. First, we changed the fundus image to a green channel and extracted the ROI of the macular area based on the optic disk. Next, we detected the candidate group using the difference image of the median filter within the ROI. We also segmented vessels and removed them from the image. Finally, we detected the drusen through Renyi’s entropy threshold algorithm. We performed comparisons and statistical analysis between the manual detection results and automatic detection results for 30 cases in order to verify validity. As a result, the average sensitivity was 93.37% (80.95%~100%) and the average DSC was 0.73 (0.3~0.98). In addition, the value of the ICC was 0.984 (CI: 0.967~0.993, p<0.01), showing the high reliability of the proposed automatic method. We expect that the automatic drusen detection helps clinicians to improve the diagnostic performance in the detection of drusen on fundus image.

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Long-term outcomes of ranibizumab treatment in neovascular age-related macular degeneration

International Eye Research ◽

10.18240/ier.2020.02.07 ◽

2020 ◽

Vol 1 (2) ◽

pp. 102-107

Author(s):

Burak Simsek ◽

◽

Isilay Ozsoy Koyun ◽

Sevil Ari Yaylali ◽

◽

...

Keyword(s):

Macular Degeneration ◽

Anterior Segment ◽

Age Related Macular Degeneration ◽

Age Related ◽

Group 3 ◽

The Difference ◽

Group 2 ◽

Number Of Injections ◽

Group 1

AIM: To investigate 3-year results in our neovascular age related macular degeneration (NV-AMD) patients treated with ranibizumab. METHODS: Retrospective study. Visual acuity (VA), a full biomicroscopic examination (anterior segment and fundus), and optical coherence tomography (OCT) findings were noted at every visit. All patients were followed monthly. The VA values for the visits closest to 12, 24, and 36mo were analysed. 101 eyes of 73 patients were enrolled. According to the initial VA, the patients were divided three groups: initial VA ≤35 (Group 1), 36-54 (Group 2), and ≥55 letters (Group 3). After three loading doses of 0.5 mg ranibizumab if retreatment was needed, again, 0.5 mg ranibizumab was administered RESULTS: Totally 57 of the 101 eyes were from males and 44 were from females. The average age was 75.1 years. The difference on the changes of VA among three groups at 24 and 36mo were statistically significant (P=0.02 and 0.001 respectively). At the end of the 36-month follow-up the VA increase in Group 2 was significant (P=0.001). At the 12, 24, and 36mo visits most of the eyes showed no VA loss and most of these eyes were in Group 1. The average number of injections administered was 7.3 and the average number of visits was 23.9 during the follow-up. CONCLUSION: VA improvement was significant in those with mild initial VA (36-54 letters). Most eyes showed no VA loss regardless of the initial VA. No correlation between the final VA and the average number of injections.

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Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

Therapeutische Umschau ◽

10.1024/0040-5930.58.1.28 ◽

2001 ◽

Vol 58 (1) ◽

pp. 28-35 ◽

Cited By ~ 1

Author(s):

Ursula Körner-Stiefbold

Keyword(s):

Macular Degeneration ◽

Clinical Features ◽

Altersbedingte Makuladegeneration ◽

Age Related Macular Degeneration ◽

Genetische Faktoren ◽

Age Related ◽

Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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