Muscle artifacts in single trial EEG data distinguish patients with Parkinson's disease from healthy individuals

2014 ◽  
Author(s):  
Jonathan Weyhenmeyer ◽  
Manuel E. Hernandez ◽  
Claudia Lainscsek ◽  
Terrence J. Sejnowski ◽  
Howard Poizner
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Individuals ◽  
Single Trial ◽  
Eeg Data

scholarly journals A-079 Hand Preference in Men and Women with Parkinson’s Disease: A Preliminary Investigation

2020 ◽  
Vol 35 (6) ◽  
pp. 871-871
Author(s):  
Ryan J ◽  
Kreiner D ◽  
Gontkovsky S ◽  
Paolo A
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurological Disorders ◽  
Rating Scale ◽  
Preliminary Investigation ◽  
Hand Preference ◽  
Dominant Hand ◽  
Healthy Individuals ◽  
Left Handed ◽  
Increased Risk

Abstract Objective Research has identified common genetic influences on handedness and neurological/mental health phenotypes. It also has been shown there may be increased risk for development of neurological disorders/diseases among individuals naturally left-handed or demonstrating non-right-hand preference. This investigation examined prevalence of right-handed versus non-right-handed individuals with Parkinson’s disease (PD) compared to controls. Method Participants were 264 patients with PD (mean age = 69.83 years) and 256 control volunteers (mean age = 71.42 years). Mean Dementia Rating Scale composites for the groups were 123.68 and 136.00, respectively. Participants self-identified their dominant hand for writing and usage was confirmed during the session. Results Proportions of non-right- and right-handed controls (7.0% and 93.0%) versus individuals with PD (6.8% and 93.2%) did not differ. Changes in proportions of non-right- and right-handedness across age ranges were not significant for controls or patients. There was a trend for a larger proportion of women (55.9%) versus men among controls (44.1%), □ 2 (1) = 3.29, p < .10; whereas, the proportion of men (64.4%) with PD was larger than that of women. (35.6%), □ 2 (1) = 21.31, p < .001. For controls and patients, non-right and right handedness gender proportions were similar. Conclusions This study is the first to assess handedness prevalence rates in PD. Results suggest prevalence of non-right handedness is similar in PD and healthy individuals and does not appear to differ markedly by gender or with advancing age. The occurrence of a trend for a larger proportion of women than men among controls is consistent with census-based statistics.

P2-243: THE BLOOD PROFILE OF MTDNA ENCODED GENES EXPRESSION IN PARKINSON'S DISEASE PATIENTS AND HEALTHY INDIVIDUALS

2006 ◽  
Vol 14 (7S_Part_14) ◽  
pp. P766-P766
Author(s):  
Duygu Gezen-Ak ◽  
Gençer Genç ◽  
Merve Alaylıoğlu ◽  
Busra Sengul ◽  
Esra Kochan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Healthy Individuals ◽  
Blood Profile ◽  
Genes Expression

scholarly journals Non-Linear Dynamical Analysis of EEG Time Series Distinguishes Patients with Parkinson’s Disease from Healthy Individuals

2013 ◽  
Vol 4 ◽  
Author(s):  
Claudia Lainscsek ◽  
Manuel E. Hernandez ◽  
Jonathan Weyhenmeyer ◽  
Terrence J. Sejnowski ◽  
Howard Poizner
Keyword(s):  
Parkinson’S Disease ◽  
Time Series ◽  
Parkinson's Disease ◽  
Dynamical Analysis ◽  
Healthy Individuals ◽  
Non Linear

scholarly journals Progressive Resistance Exercise and Parkinson's Disease: A Review of Potential Mechanisms

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Fabian J. David ◽  
Miriam R. Rafferty ◽  
Julie A. Robichaud ◽  
Janey Prodoehl ◽  
Wendy M. Kohrt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Resistance Exercise ◽  
Cortical Activation ◽  
Future Research ◽  
Healthy Individuals ◽  
Beneficial Effects ◽  
Positive Effects ◽  
Progressive Resistance Exercise ◽  
Progressive Resistance

This paper reviews the therapeutically beneficial effects of progressive resistance exercise (PRE) on Parkinson's disease (PD). First, this paper discusses the rationale for PRE in PD. Within the first section, the review discusses the central mechanisms that underlie bradykinesia and muscle weakness, highlights findings related to the central changes that accompany PRE in healthy individuals, and extends these findings to individuals with PD. It then illustrates the hypothesized positive effects of PRE on nigro-striatal-thalamo-cortical activation and connectivity. Second, it reviews recent findings of the use of PRE in individuals with PD. Finally, knowledge gaps of using PRE on individuals with PD are discussed along with suggestions for future research.

scholarly journals Significantly Reduced Salivary Nitric Oxide Synthesis in Patients with Parkinson’s Disease

2005 ◽  
Vol 5 (3) ◽  
pp. 86-89 ◽  
Author(s):  
Jasminko Huskić ◽  
Alma Paperniku ◽  
Azra Husić ◽  
Faruk Alendar ◽  
Nedžad Mulabegović
Keyword(s):  
Nitric Oxide ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Flow Rate ◽  
Healthy Subjects ◽  
Colorimetric Method ◽  
Healthy Individuals ◽  
Saliva Flow Rate ◽  
Griess Reaction ◽  
Saliva Flow

In order to study concentration of nitric oxide (NO) in the saliva of patients with Parkinson’s disease (PD), we measured the concentration of its stable metabolite nitrite (NO2-) in the saliva of these patients and healthy subjects. We analyzed saliva flow rate and salivary NO concentrations in 16 subjects with Parkinson’s disease and in 16 healthy subjects. Concentration of nitrite was determined by colorimetric method using Griess reaction. Saliva flow rate was significantly lower in patients with Parkinson’s disease (0,2±0,03 mL/min; X±SEM) than in healthy subjects. Salivary NO2-concen-tration was significantly lower (5,0210,64) than in healthy individuals (22,3911,24; p<0,0001).

scholarly journals Neuronal Dynamics of Pain in Parkinson’s Disease

2021 ◽  
Vol 11 (9) ◽  
pp. 1224
Author(s):  
Kaoru Kinugawa ◽  
Tomoo Mano ◽  
Kazuma Sugie
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Symptom ◽  
Neuronal Dynamics ◽  
Whole Brain ◽  
Neuronal Synchronization ◽  
Time Frequency ◽  
Eeg Data ◽  
Significant Difference

Pain is an important non-motor symptom of Parkinson’s disease (PD). It negatively impacts the quality of life. However, the pathophysiological mechanisms underlying pain in PD remain to be elucidated. This study sought to use electroencephalographic (EEG) coherence analysis to compare neuronal synchronization in neuronal networks between patients with PD, with and without pain. Twenty-four patients with sporadic PD were evaluated for the presence of pain. Time-frequency and coherence analyses were performed on their EEG data. Whole-brain and regional coherence were calculated and compared between pain-positive and pain-negative patients. There was no significant difference in the whole-brain coherence between the pain-positive and pain-negative groups. However, temporal–temporal coherence differed significantly between the two groups (p = 0.031). Our findings indicate that aberrant synchronization of inter-temporal regions is involved in PD-related pain. This will further our understanding of the mechanisms underlying pain in PD.

scholarly journals Effects of Physical Activity Levels on Fatigue Perception in Patients with Parkinson’s Disease and Neurologically Healthy Individuals

Health ◽  
2014 ◽  
Vol 06 (21) ◽  
pp. 2927-2933 ◽  
Author(s):  
Paulo Cezar Rocha dos Santos ◽  
Fabio Augusto Barbieri ◽  
Diego Orcioli-Silva ◽  
Lucas Simieli ◽  
Lilian Teresa Bucken Gobbi
Keyword(s):  
Physical Activity ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Activity Levels ◽  
Healthy Individuals ◽  
Physical Activity Levels

scholarly journals Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2020 ◽  
Author(s):  
Valentina Arnao ◽  
Antonio Cinturino ◽  
Sergio Mastrilli ◽  
Carmelo Buttà ◽  
Carlo Maida ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Ambulatory Setting ◽  
Healthy Individuals

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. Purpose To evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Method Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson’s disease patients and healthy controls.Conclusion In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.

scholarly journals Impaired circadian heart rate variability in Parkinson’s disease: a time-domain analysis in ambulatory setting

2020 ◽  
Author(s):  
Valentina Arnao ◽  
Antonio Cinturino ◽  
Sergio Mastrilli ◽  
Carmelo Buttà ◽  
Carlo Maida ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Heart Rate ◽  
Parkinson's Disease ◽  
Heart Rate Variability ◽  
Time Domain ◽  
Time Domain Analysis ◽  
Domain Analysis ◽  
Ambulatory Setting ◽  
Healthy Individuals

Abstract Background Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. Purpose To evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Method Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-hour ambulatory ECG was performed. Results Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ±8.8, disease duration: 5.0±4.7). Mean SCOPA-AUT score was 10.1±7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-minute standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson’s disease patients and healthy controls. Conclusion In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.

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