A novel metering component for volume management in flow-based microfluidic biochips

2018 ◽  
Author(s):  
Alexander Schneider ◽  
Paul Pop ◽  
Jan Madsen
Keyword(s):  
Volume Management ◽  
Microfluidic Biochips

Placement of Digital Microfluidic Biochips via a New Evolutionary Algorithm

2021 ◽  
Vol 26 (6) ◽  
pp. 1-22
Author(s):  
Chen Jiang ◽  
Bo Yuan ◽  
Tsung-Yi Ho ◽  
Xin Yao
Keyword(s):  
Evolutionary Algorithm ◽  
Resource Constraints ◽  
Scheduling Algorithm ◽  
Search Space ◽  
Placement Problem ◽  
Heuristic Scheduling ◽  
Microfluidic Biochips ◽  
Feasible Solutions ◽  
Digital Microfluidic ◽  
Operation Scheduling

Digital microfluidic biochips (DMFBs) have been a revolutionary platform for automating and miniaturizing laboratory procedures with the advantages of flexibility and reconfigurability. The placement problem is one of the most challenging issues in the design automation of DMFBs. It contains three interacting NP-hard sub-problems: resource binding, operation scheduling, and module placement. Besides, during the optimization of placement, complex constraints must be satisfied to guarantee feasible solutions, such as precedence constraints, storage constraints, and resource constraints. In this article, a new placement method for DMFB is proposed based on an evolutionary algorithm with novel heuristic-based decoding strategies for both operation scheduling and module placement. Specifically, instead of using the previous list scheduler and path scheduler for decoding operation scheduling chromosomes, we introduce a new heuristic scheduling algorithm (called order scheduler) with fewer limitations on the search space for operation scheduling solutions. Besides, a new 3D placer that combines both scheduling and placement is proposed where the usage of the microfluidic array over time in the chip is recorded flexibly, which is able to represent more feasible solutions for module placement. Compared with the state-of-the-art placement methods (T-tree and 3D-DDM), the experimental results demonstrate the superiority of the proposed method based on several real-world bioassay benchmarks. The proposed method can find the optimal results with the minimum assay completion time for all test cases.

Integrated Control-Fluidic Codesign Methodology for Paper-Based Digital Microfluidic Biochips

2020 ◽  
Vol 39 (3) ◽  
pp. 613-625 ◽  
Author(s):  
Qin Wang ◽  
Weiqing Ji ◽  
Zeyan Li ◽  
Haena Cheong ◽  
Oh-Sun Kwon ◽  
...  
Keyword(s):  
Integrated Control ◽  
Microfluidic Biochips ◽  
Digital Microfluidic

scholarly journals Intensive Care in a Patient with Toxic Epidermal Necrolysis

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
J. Wallenborn ◽  
M. Fischer
Keyword(s):  
Adverse Drug Reaction ◽  
Medical Care ◽  
Toxic Epidermal Necrolysis ◽  
Marked Improvement ◽  
Pain Therapy ◽  
The Body ◽  
Rapid Progression ◽  
Volume Management ◽  
Multiresistant Bacteria ◽  
Mucosal Involvement

Toxic epidermal necrolysis (TEN) is a serious adverse drug reaction with high lethality, which usually requires intensive-medical care. A 44-year-old man developed generalized exanthema with increasing exfoliation and mucosal involvement after taking allopurinol, ibuprofen, and etoricoxib. The clinical diagnosis of TEN was histologically confirmed. Prednisolone therapy with 3 mg/kg body weight (BW) was not able to prevent further progress to finally 80% of the body surface, and infliximab 5 mg/kg BW was given as a single dose. This prevented further progression of the TEN. Despite marked improvement in skin findings, the ICU stay was prolonged by a complex analgosedation, transient kidney failure, volume management, positioning therapy, and vegetatively impeded weaning. Moreover, there was colonization with multiresistant bacteria (MRSA and VRE). Nonetheless, the patient could be restored to health and was released after four weeks. Infliximab seems to be effective in the treatment of TEN, especially in cases of rapid progression. Moreover, patients with TEN are difficult to handle in intensive-medical care, whereby attention should especially be paid to sufficient pain therapy, and the positioning of the patient is a particular challenge.

Optimal Testing of Digital Microfluidic Biochips

2011 ◽  
Vol 23 (4) ◽  
pp. 518-529 ◽  
Author(s):  
Bogdan Paşaniuc ◽  
Robert Garfinkel ◽  
Ion Măndoiu ◽  
Alex Zelikovsky
Keyword(s):  
Microfluidic Biochips ◽  
Digital Microfluidic

Multiple fault diagnosis in digital microfluidic biochips

2006 ◽  
Vol 2 (4) ◽  
pp. 262-276 ◽  
Author(s):  
Daniel Davids ◽  
Siddhartha Datta ◽  
Arindam Mukherjee ◽  
Bharat Joshi ◽  
Arun Ravindran
Keyword(s):  
Fault Diagnosis ◽  
Multiple Fault ◽  
Multiple Fault Diagnosis ◽  
Microfluidic Biochips ◽  
Digital Microfluidic
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