scholarly journals Hardware-Software Integrated Diagnosis for Intermittent Hardware Faults

2014 ◽  
Author(s):  
Majid Dadashi ◽  
Layali Rashid ◽  
Karthik Pattabiraman ◽  
Sathish Gopalakrishnan
Keyword(s):  
Integrated Diagnosis ◽  
Hardware Faults

scholarly journals PATH-17. INTRAGENIC COPY NUMBER BREAKPOINT ANALYSIS OF METHYLATION DATA FROM CNS TUMOURS IDENTIFIES NOVEL SUBGROUP-SPECIFIC CANDIDATE FUSION GENE ENRICHMENTS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii427-iii428
Author(s):  
Alan Mackay ◽  
Yura Grabovska ◽  
Matthew Clarke ◽  
Diana Carvalho ◽  
Sara Temelso ◽  
...  
Keyword(s):  
Copy Number ◽  
Fusion Gene ◽  
High Grade Glioma ◽  
Structural Variations ◽  
Methylation Array ◽  
Kinase Gene ◽  
Integrated Diagnosis ◽  
Cns Tumours ◽  
Breakpoint Analysis ◽  
Balanced Translocations

Abstract Methylation array-based molecular profiling has redefined the classification of brain tumours and now forms an important part of their integrated diagnosis, providing both subgroup assignment and genome wide DNA copy number profiles. These latter data can be used to identify intragenic breakpoints which are frequently associated with structural variations resulting in therapeutically targetable oncogenic fusion genes. To systematically assess the landscape of these alterations, we combined publicly available methylation datasets resulting in a total of 5660 CNS tumours, around half paediatric, and including >1000 high grade glioma and DIPG. These were analysed by standard methodology (MNP, conumee), and intragenic breakpoint enrichment was compared within methylation subgroups, superfamilies, and tumours with no high-scoring classification. Benchmarking included sequence-verified cases such as infant hemispheric gliomas (IHG) with ALK(15%) and ROS1(7%) fusions, and pathognomic alterations associated with specific entities such as RELA-EPN, MYB-LGG and HGNET-MN1. We identified previously unreported enrichments of well-recognised fusion targets such as NTRK2in GBM_MID and NTRK3in DMG_K27 (both 5%), METin A_IDH / A_IDH_HG (3–5%), and FGFR1/3in GBM_G34 (8–9%). Novel recurrent kinase gene candidates to be verified and explored further include IGF1Rin 2–12% cases spanning glioma subgroups, and TIE1in poorly classified tumours. This latter ‘NOS’ group were also enriched in various transcription factor targets of breakpoints, including TCF4and PLAGL2. Despite limitations due to sample quality, resolution or balanced translocations, breakpoint analysis of methylation copy number profiles provides simple screening for structural rearrangements which may directly influence targeted therapy in paediatric CNS tumours.

Hybrid Software Redundancy Approach for Building Reliable Communication in Multi-BUS Heterogeneous Systems

2016 ◽  
Vol 23 (04) ◽  
pp. 1650013
Author(s):  
Chafik Arar ◽  
Mohamed Salah Khireddine
Keyword(s):  
Fault Tolerant ◽  
Scheduling Algorithm ◽  
Heterogeneous Systems ◽  
Reliable Communication ◽  
Data Dependencies ◽  
Data Scheduling ◽  
Static Scheduling ◽  
Heterogeneous Architectures ◽  
Multiple Processors ◽  
Hardware Faults

The paper proposes a new reliable fault-tolerant scheduling algorithm for real-time embedded systems. The proposed algorithm is based on static scheduling that allows to include the dependencies and the execution cost of tasks and data dependencies in its scheduling decisions. Our scheduling algorithm is dedicated to multi-bus heterogeneous architectures with multiple processors linked by several shared buses. This scheduling algorithm is considering only one bus fault caused by hardware faults and compensated by software redundancy solutions. The proposed algorithm is based on both active and passive backup copies to minimize the scheduling length of data on buses. In the experiments, the proposed methods are evaluated in terms of data scheduling length for a set of DSP benchmarks. The experimental results show the effectiveness of our technique.

scholarly journals An Efficient Fault-Tolerant Multi-Bus Data Scheduling Algorithm Based on Replication and Deallocation

2016 ◽  
Vol 16 (2) ◽  
pp. 69-84
Author(s):  
Chafik Arar ◽  
Mohamed Salah Khireddine
Keyword(s):  
Embedded Systems ◽  
Real Time ◽  
Fault Tolerant ◽  
Scheduling Algorithm ◽  
Experimental Results ◽  
Data Scheduling ◽  
Heterogeneous Architectures ◽  
Hardware Faults

Abstract The paper proposes a new reliable fault-tolerant scheduling algorithm for real-time embedded systems. The proposed scheduling algorithm takes into consideration only one bus fault in multi-bus heterogeneous architectures, caused by hardware faults and compensated by software redundancy solutions. The proposed algorithm is based on both active and passive backup copies, to minimize the scheduling length of data on buses. In the experiments, this paper evaluates the proposed methods in terms of data scheduling length for a set of DAG benchmarks. The experimental results show the effectiveness of our technique.

“Integrated diagnosis” of pilocytic astrocytoma: Molecular diagnostic procedure for an unusual case

2018 ◽  
Vol 68 (12) ◽  
pp. 694-699 ◽  
Author(s):  
Yusuke Ishida ◽  
Masumi Tsuda ◽  
Yutaka Sawamura ◽  
Kyoko Fujii ◽  
Hiroshi Murai ◽  
...  
Keyword(s):  
Pilocytic Astrocytoma ◽  
Diagnostic Procedure ◽  
Unusual Case ◽  
Molecular Diagnostic ◽  
Integrated Diagnosis

Superposed Redundancy Approach for Building Reliable Communication in Multi-Bus Heterogeneous Systems

2019 ◽  
Vol 10 (1) ◽  
pp. 1-21
Author(s):  
Chafik Arar
Keyword(s):  
Fault Tolerant ◽  
Scheduling Algorithm ◽  
Heterogeneous Systems ◽  
List Scheduling ◽  
Reliable Communication ◽  
Data Scheduling ◽  
New Variant ◽  
Hardware Faults

In this article, the author uses a new variant of passive redundancy, which allows for a fictitious dual assignment by simultaneously scheduling two backup copies that overlap on the same communication bus at a given time. The proposed reliable fault tolerant greedy list scheduling algorithm is based on a superposed backup copy. This scheduling algorithm is considering up to n communication buses faults, caused by hardware faults and compensated by software redundancy solutions. it allows a reliable communication and efficient use of buses. In the experiments, the proposed methods are evaluated in terms of data scheduling length for a set of DSP benchmarks from the DSPstone.

scholarly journals Ovarian Cancer: Diagnostic Accuracy and Tumor Types Distribution in East Africa compared to North America

2020 ◽  
Author(s):  
Peter Fabian Rambau ◽  
Martin Köbel ◽  
Derek Tilley ◽  
Alex Mremi ◽  
Robert Lukande ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Diagnostic Accuracy ◽  
Ovarian Carcinoma ◽  
East Africa ◽  
Response To Therapy ◽  
Tumor Type ◽  
Integrated Diagnosis ◽  
Resource Limited ◽  
Haematoxylin And Eosin Stain ◽  
Tumor Types

Abstract Background Ovarian cancer is a spectrum of several histologically distinct tumor types which differ in etiology, response to therapy and prognosis. In a resource-limited settings, the diagnosis of ovarian cancer can be challenging. This study describes the distribution of ovarian cancer tumor types in East Africa as well as assessing the diagnostic accuracy by using contemporary methods. Methods Data from 210 women identified from the records with a diagnosis of ovarian cancer in a period of 15 years were included. Two tissue microarrays were constructed and stained with 20 antibodies relevant to ovarian cancer subtyping. An integrated diagnosis was reached by the review of full Haematoxylin and Eosin stained sections, with consideration of immunohistochemical results. The integrated diagnoses were compared with the original diagnoses, and the degree of agreement was evaluated by percentage and Kappa statistics. Results The estimated rates of ovarian cancer were much lower in East Africa compared to a North American population from Alberta, Canada. There was a higher proportion of sex cord stromal tumors and germ cell tumors in the East African population. Diagnostic accuracy for main ovarian tumor type categories was substantial (Kappa 0.70), but only fair for specific ovarian carcinoma histotypes (Kappa 0.34). Poor Haematoxylin and Eosin stain was the main factor hindering correct diagnosis, which was not related to tissue processing. Conclusions In a resource- limited setting, where immunohistochemistry is not routinely carried out, diagnostic accuracy for the main categories of ovarian carcinoma is substantial and could be further improved by standardization of the basic Haematoxylin and Eosin stain.

scholarly journals CTNI-22. RETROSPECTIVE ANALYSIS OF THE COMBINED TREATMENT OF VINCRISTINE, ACNU, CARBOPLATIN AND INTERFERON-β PLUS RADIOTHERAPY (VAC-FERON-R)IN PATIENTS WITH DIFFUSE ASTROCYTOMA

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii47-ii47
Author(s):  
Yoshiki Arakawa ◽  
Yasuhide Makino ◽  
Takeshi Kawauchi ◽  
Masaharu Tanji ◽  
Yohei Mineharu ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Diffuse Astrocytoma ◽  
Wild Type ◽  
Interferon Β ◽  
Mutant Type ◽  
Who Grade ◽  
Integrated Diagnosis ◽  
Significant Difference ◽  
Favorable Clinical Outcome ◽  
The Impact

Abstract OBJECTIVE Diffuse astrocytomas are classified as WHO grade II and its median overall survival (mOS) is 10 to 11 years. The efficacy of chemoradiation in the high-risk feature has been reported. The prognosis is associated with IDH and TERT promoter (TERTp) mutations. Here, we retrospectively analyzed the patients with diffuse astrocytoma treated with vincristine, ACNU, carboplatin and interferon-β plus radiotherapy (VAC-feron-R)in our institute. PATIENTS AND METHODS Between December 2003 to January 2016, 44 patients were diagnosed as diffuse astrocytoma with integrated diagnosis of histological and molecular analysis. The average age was 43.1 years (22–71 years). They received VAC-feron-R as initial treatment in our institute. We analyzed the IDH1/2 and the TERTp mutation using Sangar sequencing and determined the 1p/19q codeletion by the fluorescence in situ hybridization or the multiplex ligation-dependent probe amplification. RESULTS Median follow-up period was 76.5 months, mPFS was 126 months, mOS did not reach, and 10-year survival rate was 60%.IDH status was determined in 29 patients, 9 mutant and 20 wild types. There was no significant difference in PFS and OS between the two groups. TERTp status was determined in 18 patients with IDH wild type, 6 mutant and 12 wild types. mPFS of patients with TERTp wild type did not reach, but that with TERTp mutant type was 34.5 months (p = 0.0356). CONCLUSION Compared with previous clinical studies, VAC-feron-R showed a favorable clinical outcome in diffuse astrocytoma. The impact of TERTp status on prognosis was identified but not IDH status in this cohort.

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