“Integrated diagnosis” of pilocytic astrocytoma: Molecular diagnostic procedure for an unusual case

2018 ◽  
Vol 68 (12) ◽  
pp. 694-699 ◽  
Author(s):  
Yusuke Ishida ◽  
Masumi Tsuda ◽  
Yutaka Sawamura ◽  
Kyoko Fujii ◽  
Hiroshi Murai ◽  
...  
Keyword(s):  
Pilocytic Astrocytoma ◽  
Diagnostic Procedure ◽  
Unusual Case ◽  
Molecular Diagnostic ◽  
Integrated Diagnosis

scholarly journals A Diagnostic Approach to Endometrial Cytology by Means of Liquid-Based Preparations

2019 ◽  
Vol 64 (3) ◽  
pp. 195-207 ◽  
Author(s):  
Yoshiaki Norimatsu ◽  
Kenji Yanoh ◽  
Yasuo Hirai ◽  
Tetsuji Kurokawa ◽  
Tadao K. Kobayashi ◽  
...  
Keyword(s):  
Diagnostic Procedure ◽  
Molecular Diagnostic ◽  
The Past ◽  
Number Of Factors ◽  
Standardized Terminology ◽  
Liquid Based Cytology ◽  
Endometrial Cytology

The adoption of endometrial cytology as a diagnostic procedure has been hampered in the past by difficulties arising in interpreting the cellular findings due to a number of factors (such as excess blood, cellular overlapping, and the complex physiology of endometrium). Recently, the use of liquid-based cytology (LBC), with its ability to remove blood and mucus and to distribute cells uniformly in a thin layer on the slide, has provided an opportunity to reevaluate the role of endometrial cytology. LBC samples are easier to screen compared to conventional ones, due to a smaller screening area and an excellent quality of cell preparations. LBC by using peculiar cytoarchitectural features is a useful tool in the cellular diagnosis and follow-up of abnormalities, which, however, remains complementary to histopathology and to the emerging molecular diagnostic cytopathology. This review discusses these various entities and takes into consideration the ancillary techniques that may be useful in the diagnostic procedure. Herein, we also summarize the process and rationale by which updates were made to the standardized terminology in 2018 and outline the contents of the new Bethesda-style classification (the Yokohama system) for the endometrial cytology.

Cystic Glioma of the Brain Stem with Prolonged Survival

Neurosurgery ◽  
1982 ◽  
Vol 10 (4) ◽  
pp. 499-502 ◽  
Author(s):  
Dov Soffer ◽  
Abraham Sahar
Keyword(s):  
Brain Stem ◽  
Pilocytic Astrocytoma ◽  
Unusual Case ◽  
Prolonged Survival ◽  
Biological Behavior ◽  
Favorable Prognosis ◽  
Pilocytic Astrocytomas ◽  
The Brain ◽  
Cystic Glioma

Abstract An unusual case of benign stem glioma with a 15-year survival is presented. In spite of 12 years of clinical quiescence, a focus of the tumor in the upper brain stem was found at necropsy. Morphologically, the tumor was a cystic pilocytic astrocytoma. The few previously reported similar cases in the same location were also associated with a favorable prognosis. It is suggested that, in analogy to the cystic cerebellar and cerebral astrocytomas, there is a group of cystic pilocytic astrocytomas of the brain stem with benign biological behavior.

scholarly journals A Complete Molecular Diagnostic Procedure for Applications in Surveillance and Subtyping of Avian Influenza Virus

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Chun-Hsien Tseng ◽  
Hsiang-Jung Tsai ◽  
Chung-Ming Chang
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Genome Sequencing ◽  
Viral Genome ◽  
Diagnostic Procedure ◽  
Molecular Diagnostic ◽  
Influenza Surveillance ◽  
Real Time Quantitative Pcr ◽  
Step Procedure

Introduction. The following complete molecular diagnostic procedure we developed, based on real-time quantitative PCR and traditional PCR, is effective for avian influenza surveillance, virus subtyping, and viral genome sequencing.Method. This study provides a specific and sensitive step-by-step procedure for efficient avian influenza identification of 16 hemagglutinin and 9 neuraminidase avian influenza subtypes.Result and Conclusion. This diagnostic procedure may prove exceedingly useful for virological and ecological advancements in global avian influenza research.

An unusual case of malignant pilocytic astrocytoma occurring in the eye

2006 ◽  
Vol 449 (2) ◽  
pp. 248-252 ◽  
Author(s):  
Alessandra Canesso ◽  
Marina Gardiman ◽  
Roberto Salmaso ◽  
Rita Alaggio ◽  
Vito Ninfo
Keyword(s):  
Pilocytic Astrocytoma ◽  
Unusual Case

scholarly journals Adult pilocytic astrocytoma in the molecular era: a comprehensive review

CNS Oncology ◽  
2021 ◽  
pp. CNS68
Author(s):  
Timothy A Gregory ◽  
Lyndon B Chumbley ◽  
John W Henson ◽  
Brett J Theeler
Keyword(s):  
Targeted Therapy ◽  
Pilocytic Astrocytoma ◽  
Mapk Pathway ◽  
Comprehensive Review ◽  
Molecular Alterations ◽  
Molecular Features ◽  
Integrated Diagnosis ◽  
Investigational Therapies ◽  
Worse Prognosis ◽  
Pathway Dysregulation

Adult pilocytic astrocytoma (PA) is less prevalent than pediatric PA and is associated with a worse prognosis. In a literature review, we found that 88.3% of the molecular alterations in adult PA are associated with MAPK pathway dysregulation. The most common alterations are fusions of BRAF. Understanding of the mechanisms underlying this pathway has evolved substantially, heralding advancements in specific targeted therapy. Here, we review clinical and molecular features of adult PA, characteristics predicting aggressive behavior and approaches to standard and investigational therapies. We highlight epigenetic profiling and integrated diagnosis as an essential component of classifying PA.

Variable erythrokeratoderma. An unusual case

1969 ◽  
Vol 100 (6) ◽  
pp. 744-748 ◽  
Author(s):  
F. G. Schellander
Keyword(s):  
Unusual Case

An unusual case of suntanning

1978 ◽  
Vol 114 (2) ◽  
pp. 287b-287
Author(s):  
G. P. Ream
Keyword(s):  
Unusual Case

An Unusual Case of Actinomycosis Manifested as an Abdominal Wall Abscess

1957 ◽  
Vol 33 (5) ◽  
pp. 830-836 ◽  
Author(s):  
R.A. MacHaffie ◽  
Robert L. Zaayer ◽  
Herbert Saichek ◽  
A.L. Sciortino
Keyword(s):  
Abdominal Wall ◽  
Unusual Case ◽  
Abdominal Wall Abscess
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