Behavior of new ZnSe(Te,O) semiconductor scintillators under high doses of ionizing radiation

2001 ◽  
Vol 48 (4) ◽  
pp. 1561-1564 ◽  
Author(s):  
V.D. Ryzhikov ◽  
N.G. Starzhinskiy ◽  
L.P. Gal'chinetskii ◽  
M. Guttormsen ◽  
A.A. Kist ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
High Doses

scholarly journals Radiation Produces Irreversible Chronic Dysfunction in the Submandibular Glands of the Rat

2012 ◽  
Vol 6 (1) ◽  
pp. 8-13 ◽  
Author(s):  
C De la Cal ◽  
J Fernández-Solari ◽  
CE Mohn ◽  
JP Prestifilippo ◽  
A Pugnaloni ◽  
...  
Keyword(s):  
Single Dose ◽  
Salivary Gland ◽  
Ionizing Radiation ◽  
Salivary Secretion ◽  
Maximal Response ◽  
Chronic Effect ◽  
Post Irradiation ◽  
Gland Function ◽  
High Doses ◽  
Rat Salivary Gland

The exposure to high doses of ionizing radiation during radiotherapy results in severe morphological and functional alterations of the salivary glands, such as xerostomia. In the present study we investigated the chronic effect of a single radiation dose of 15 Gray (Gy) limited to head and neck on rat salivary gland function (salivary secretion and gland mass) and histology. Results indicate that norepinephrine (NE)-induced salivary secretion was reduced significantly at 30, 90, 180 and 365 days after the administration of a single dose of 15 Gy of ionizing radiation compared to non-irradiated animals. The maximal secretory response was reduced by 33% at 30 and 90 days post irradiation. Interestingly, a new fall in the salivary response to NE was observed at 180 days and was maintained at 365 days post irradiation, showing a 75% reduction in the maximal response. The functional fall of the salivary secretion observed at 180 days post irradiation was not only associated with a reduction of gland mass but also to an alteration of the epithelial architecture exhibiting a changed proportion of ducts and acini, loss of eosinophilic secretor granular material, and glandular vacuolization and fibrosis. On the basis of the presented results, we conclude that ionizing radiation produces irreversible and progressive alterations of submandibular gland (SMG) function and morphology that leads to a severe salivary hypo-function.

Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the expression of NF-kappaB-dependent genes

2018 ◽  
Vol 46 ◽  
pp. 23-31 ◽  
Author(s):  
Patryk Janus ◽  
Katarzyna Szołtysek ◽  
Gracjana Zając ◽  
Tomasz Stokowy ◽  
Anna Walaszczyk ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Inflammatory Cytokine ◽  
High Doses ◽  
Nf Kappab

Radiation and transplantation

2016 ◽  
Author(s):  
Shaun R. McCann
Keyword(s):  
Stem Cell ◽  
Ionizing Radiation ◽  
Medical Technology ◽  
Sickle Cell Anaemia ◽  
Cell Transfer ◽  
Blood Disorders ◽  
Laboratory Techniques ◽  
High Doses ◽  
Total Body ◽  
The One

There is a paradoxical relationship between ionizing radiation and leukaemia. On the one hand, it is known that exposure to high doses of ionizing radiation causes leukaemia; on the other hand, the preparative regimens for stem cell transplantation, which can cure leukaemia, often contain total body irradiation. This chapter discusses the effect war has had on medical technology, with specific regard to the use of stem cells for the treatment of blood disorders such as leukaemia and sickle cell anaemia. The transfer of laboratory techniques to the clinical practice of stem cell transfer and bone marrow transplantation is also discussed.

scholarly journals High-throughput transcriptome sequencing reveals extremely high doses of ionizing radiation-response genes in Caenorhabditis elegans

2019 ◽  
Vol 8 (5) ◽  
pp. 754-766 ◽  
Author(s):  
Youqin Xu ◽  
Lina Chen ◽  
Mengyi Liu ◽  
Yanfang Lu ◽  
Yanwei Yue ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Ionizing Radiation ◽  
Differential Expression ◽  
Gene Families ◽  
Rna Degradation ◽  
Cellular Growth ◽  
Radiation Response ◽  
Signalling Pathways ◽  
C Elegans ◽  
High Doses

Abstract This study sought novel ionizing radiation-response (IR-response) genes in Caenorhabditis elegans (C. elegans). C. elegans was divided into three groups and exposed to different high doses of IR: 0 gray (Gy), 200 Gy, and 400 Gy. Total RNA was extracted from each group and sequenced. When the transcriptomes were compared among these groups, many genes were shown to be differentially expressed, and these genes were significantly enriched in IR-related biological processes and pathways, including gene ontology (GO) terms related to cellular behaviours, cellular growth and purine metabolism and kyoto encyclopedia of genes and genomes (KEGG) pathways related to ATP binding, GTPase regulator activity, and RNA degradation. Quantitative reverse-transcription PCR (qRT-PCR) confirmed that these genes displayed differential expression across the treatments. Further gene network analysis showed a cluster of novel gene families, such as the guanylate cyclase (GCY), Sm-like protein (LSM), diacylglycerol kinase (DGK), skp1-related protein (SKR), and glutathione S-transferase (GST) gene families which were upregulated. Thus, these genes likely play important roles in IR response. Meanwhile, some important genes that are well known to be involved in key signalling pathways, such as phosphoinositide-specific phospholipase C-3 (PLC-3), phosphatidylinositol 3-kinase age-1 (AGE-1), Raf homolog serine/threonine-protein kinase (LIN-45) and protein cbp-1 (CBP-1), also showed differential expression during IR response, suggesting that IR response might perturb these key signalling pathways. Our study revealed a series of novel IR-response genes in Caenorhabditis elegans that might act as regulators of IR response and represent promising markers of IR exposure.

The regulation of pollen tube growth in Douglas-fir following high doses of ionizing radiation

Planta ◽  
1978 ◽  
Vol 140 (3) ◽  
pp. 283-288 ◽  
Author(s):  
J. A. van der Donk ◽  
G. K. Livingston ◽  
H. F. Linskens ◽  
M. van der Donk
Keyword(s):  
Ionizing Radiation ◽  
Pollen Tube ◽  
Pollen Tube Growth ◽  
Douglas Fir ◽  
Tube Growth ◽  
High Doses
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