A silicon-based, three-dimensional neural interface: manufacturing processes for an intracortical electrode array

1991 ◽  
Vol 38 (8) ◽  
pp. 758-768 ◽  
Author(s):  
P.K. Campbell ◽  
K.E. Jones ◽  
R.J. Huber ◽  
K.W. Horch ◽  
R.A. Normann
Keyword(s):  
Three Dimensional ◽  
Electrode Array ◽  
Neural Interface ◽  
Manufacturing Processes ◽  
Silicon Based

scholarly journals Massively parallel microwire arrays integrated with CMOS chips for neural recording

2020 ◽  
Vol 6 (12) ◽  
pp. eaay2789 ◽  
Author(s):  
Abdulmalik Obaid ◽  
Mina-Elraheb Hanna ◽  
Yu-Wei Wu ◽  
Mihaly Kollo ◽  
Romeo Racz ◽  
...  
Keyword(s):  
Large Scale ◽  
Modular Design ◽  
Three Dimensional ◽  
Field Potential ◽  
Neural Interface ◽  
Neural Communication ◽  
New Strategy ◽  
Planar Silicon ◽  
Interface Devices ◽  
Silicon Based

Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.

scholarly journals Massively Parallel Microwire Arrays Integrated with CMOS chips for Neural Recording

2019 ◽  
Author(s):  
Abdulmalik Obaid ◽  
Mina-Elraheb Hanna ◽  
Yu-Wei Wu ◽  
Mihaly Kollo ◽  
Romeo Racz ◽  
...  
Keyword(s):  
Large Scale ◽  
Modular Design ◽  
Three Dimensional ◽  
Field Potential ◽  
Neural Interface ◽  
Neural Communication ◽  
New Strategy ◽  
Planar Silicon ◽  
Interface Devices ◽  
Silicon Based

AbstractMulti-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.

Micropattern Effect on Breast Cancer Cells Behavior on Isotropically Etched Silicon Microenvironments

2010 ◽  
Author(s):  
Mehdi Nikkhah ◽  
Jeannine S. Strobl ◽  
Bhanu Peddi ◽  
Adedamola Omotosho ◽  
Masoud Agah
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Three Dimensional ◽  
Cancer Diagnostics ◽  
Breast Cancer Diagnostics ◽  
Wide Range ◽  
Etched Silicon ◽  
Directed Motility ◽  
Etched Surface ◽  
Silicon Based

In this paper we are investigating three dimensional (3-D) silicon-based microenvironments as potential platforms for breast cancer diagnostics. We have developed isotropically etched microstructures with a wide range of geometrical patterns for this purpose. Our results indicate that with the etched surface ratio of ∼65%, it is possible to capture 80–90% of the cancer cells within each silicon chip. After treatment of the cells with mitomycin C (to block the cell growth) more number of the cells are trapped inside the etched features for longer cultures times (72 h) suggesting that there is a directed motility and attraction of the cells toward the etched cavities and by optimally designing the etched features, the proposed platforms can be potentially used for diagnostics purposes.

Research Progress and Application of Modified Silicon-Based Anode Materials for Lithium-Ion Batteries

2021 ◽  
Vol 1036 ◽  
pp. 35-44
Author(s):  
Ling Fang Ruan ◽  
Jia Wei Wang ◽  
Shao Ming Ying
Keyword(s):  
Electrochemical Performance ◽  
Lithium Ion Batteries ◽  
Volume Expansion ◽  
Anode Materials ◽  
Active Material ◽  
Three Dimensional ◽  
Lithium Ion ◽  
Research Progress ◽  
Ion Intercalation ◽  
Silicon Based

Silicon-based anode materials have been widely discussed by researchers because of its high theoretical capacity, abundant resources and low working voltage platform,which has been considered to be the most promising anode materials for lithium-ion batteries. However,there are some problems existing in the silicon-based anode materials greatly limit its wide application: during the process of charge/discharge, the materials are prone to about 300% volume expansion, which will resultin huge stress-strain and crushing or collapse on the anods; in the process of lithium removal, there is some reaction between active material and current collector, which creat an increase in the thickness of the solid phase electrolytic layer(SEI film); during charging and discharging, with the increase of cycle times, cracks will appear on the surface of silicon-based anode materials, which will cause the batteries life to decline. In order to solve these problems, firstly, we summarize the design of porous structure of nanometer sized silicon-based materials and focus on the construction of three-dimensional structural silicon-based materials, which using natural biomass, nanoporous carbon and metal organic framework as structural template. The three-dimensional structure not only increases the channel of lithium-ion intercalation and the rate of ion intercalation, but also makes the structure more stable than one-dimensional or two-dimensional. Secondly, the Si/C composite, SiOx composite and alloying treatment can improve the volume expansion effection, increase the rate of lithium-ion deblocking and optimize the electrochemical performance of the material. The composite materials are usually coated with elastic conductive materials on the surface to reduce the stress, increase the conductivity and improve the electrochemical performance. Finally, the future research direction of silicon-based anode materials is prospected.

scholarly journals A Useful Manufacturing Guide for Rotary Piercing Seamless Pipe by ALE Method

2020 ◽  
Vol 8 (10) ◽  
pp. 756
Author(s):  
Ameen Topa ◽  
Burak Can Cerik ◽  
Do Kyun Kim
Keyword(s):  
Numerical Simulations ◽  
Maximum Stress ◽  
Three Dimensional ◽  
Material Model ◽  
Manufacturing Processes ◽  
Arbitrary Lagrangian Eulerian ◽  
Analysis Method ◽  
Seamless Pipe ◽  
Ale Formulation ◽  
Good Agreement

The development of numerical simulations is potentially useful in predicting the most suitable manufacturing processes and ultimately improving product quality. Seamless pipes are manufactured by a rotary piercing process in which round billets (workpiece) are fed between two rolls and pierced by a stationary plug. During this process, the material undergoes severe deformation which renders it impractical to be modelled and analysed with conventional finite element methods. In this paper, three-dimensional numerical simulations of the piercing process are performed with an arbitrary Lagrangian–Eulerian (ALE) formulation in LS-DYNA software. Details about the material model as well as the elements’ formulations are elaborated here, and mesh sensitivity analysis was performed. The results of the numerical simulations are in good agreement with experimental data found in the literature and the validity of the analysis method is confirmed. The effects of varying workpiece velocity, process temperature, and wall thickness on the maximum stress levels of the product material/pipes are investigated by performing simulations of sixty scenarios. Three-dimensional surface plots are generated which can be utilized to predict the maximum stress value at any given combination of the three parameters.

scholarly journals Sea of Electrodes Array (SEA): Extremely Dense and High-Count Silicon-Based Electrode Array Technology for High-Resolution High-Bandwidth Interfacing with 3D Neural Structures

2021 ◽  
Author(s):  
Amin Sandoughsaz Zardini ◽  
Behnoush Rostami ◽  
Khalil Najafi ◽  
Vaughn L. Hetrick ◽  
Omar J. Ahmed
Keyword(s):  
Aspect Ratio ◽  
High Aspect Ratio ◽  
Electrode Array ◽  
High Count ◽  
Array Technology ◽  
High Bandwidth ◽  
Length Width ◽  
Silicon Based ◽  
The Brain

AbstractIn this work, we propose a new silicon-based micro-fabrication technology to fabricate 3D high-density high-electrode-count neural micro-probe arrays scalable to thousands and even millions of individual electrodes with user-defined length, width, shape, and tip profile. This unique technology utilizes DRIE of ultra-high aspect-ratio holes in silicon and refilling them with multiple films to form thousands of individual needles with metal tips making up the “sea-of-electrodes” array (SEA). World-record density of 400 electrodes/mm2 in a 5184-needle array is achieved. The needles are ~0.5-1.2mm long, <20μm wide at the base, and <1μm at the tip. The silicon-based structure of these 3D array probes with sharp tips, makes them stiff enough and easily implantable in the brain to reach a targeted region without failing. Moreover, the high aspect ratio of these extremely fine needles reduces the tissue damage and improves the chronic stability. Functionality of the electrodes is investigated using acute in vivo recording in a rat barrel field cortex under isoflurane anesthesia.

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