scholarly journals Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors

2018 ◽  
Vol 30 (10) ◽  
pp. 2573-2593 ◽  
Author(s):  
Kiril Mishev ◽  
Qing Lu ◽  
Bram Denoo ◽  
François Peurois ◽  
Wim Dejonghe ◽  
...  
Keyword(s):  
Sec7 Domain ◽  
Chemical Inhibition

scholarly journals Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sivamoke Dissook ◽  
Tomohisa Kuzuyama ◽  
Yuri Nishimoto ◽  
Shigeru Kitani ◽  
Sastia Putri ◽  
...  
Keyword(s):  
Yarrowia Lipolytica ◽  
Oleaginous Yeast ◽  
Isoprenoid Biosynthesis ◽  
Mep Pathway ◽  
Authentic Standard ◽  
Chemical Inhibition ◽  
Chromatographic Peaks ◽  
Methyl Erythritol Phosphate ◽  
Limiting Condition ◽  
Yeast Yarrowia Lipolytica

AbstractMethyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia lipolytica, in which one of the chromatographic peaks was annotated as MEP when cultivated in the nitrogen limiting condition. This finding raised an interesting hypothesis of whether Y. lipolytica utilizes the MEP pathway for isoprenoid biosynthesis or not, because there is no report of yeast harboring the MEP pathway. Three independent approaches were used to investigate the existence of the MEP pathway in Y. lipolytica; the spiking of the authentic standard, the MEP pathway inhibitor, and the 13C labeling incorporation analysis. The study suggested that the mevalonate and MEP pathways co-exist in Y. lipolytica and the nitrogen limiting condition triggers the utilization of the MEP pathway in Y. lipolytica.

Characterization and Prediction of Chemical Inhibition Performance for Erosion-Corrosion Conditions in Sweet Oil and Gas Production

CORROSION ◽  
10.5006/0546 ◽  
2012 ◽  
Vol 68 (10) ◽  
pp. 885-896 ◽  
Author(s):  
Sh. Hassani ◽  
K.P. Roberts ◽  
S.A. Shirazi ◽  
J.R. Shadley ◽  
E.F. Rybicki ◽  
...  
Keyword(s):  
Oil And Gas ◽  
Gas Production ◽  
Oil And Gas Production ◽  
Erosion Corrosion ◽  
Chemical Inhibition ◽  
Inhibition Performance

scholarly journals Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia

2013 ◽  
Vol 305 (3) ◽  
pp. H403-H409 ◽  
Author(s):  
Amanda L. Sharpe ◽  
Mary Ann Andrade ◽  
Myrna Herrera-Rosales ◽  
Steven L. Britton ◽  
Lauren G. Koch ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Aerobic Capacity ◽  
Intermittent Hypoxia ◽  
Chronic Intermittent Hypoxia ◽  
Neurogenic Hypertension ◽  
Body Weights ◽  
Aerobic Exercise Capacity ◽  
Chemical Inhibition ◽  
Ganglionic Transmission ◽  
Selection Of

Exposure to chronic intermittent hypoxia (CIH) is an animal model that mimics the repetitive bouts of hypoxemia experienced by humans with sleep apnea. Rats exposed to CIH develop hypertension that depends on the activation of sympathetic nerve activity (SNA). Since obesity and metabolic syndrome have been linked to neurogenic hypertension and sleep apnea, and because sleep apnea can adversely affect aerobic exercise capacity, we tested the hypothesis that rats bred for selection of low aerobic capacity running (LCR) would have a greater hypertensive response to CIH than rats bred for high aerobic capacity running (HCR). Blockade of ganglionic transmission was performed to compare the contribution of SNA to the maintenance of resting mean arterial pressure (MAP). Next, hypertensive responses to 7 days of CIH were compared across LCR and HCR rats (14–16 mo old). Finally, the contribution of the hypothalamic paraventricular nucleus (PVN) to the maintenance of SNA and hypertension after CIH was determined and compared across groups. Although LCR rats were less active and had greater body weights than HCR rats, resting MAP, the contribution of ongoing SNA to the maintenance of MAP, and hypertensive responses to CIH were similar between groups. Contrary to our hypothesis, chemical inhibition of the PVN with muscimol (1 mmol/100 nl) caused a larger fall of MAP in HCR rats than in LCR rats. We conclude that LCR rats do not have resting hypertension or an exaggerated hypertensive response to CIH. Interestingly, the maintenance of CIH hypertension in LCR rats compared with HCR rats appears less reliant on ongoing PVN neuronal activity.

Chemical inhibition of dehydroquinate synthase

1989 ◽  
Vol 111 (5) ◽  
pp. 1861-1866 ◽  
Author(s):  
S. Myrvold ◽  
L. M. Reimer ◽  
D. L. Pompliano ◽  
J. W. Frost
Keyword(s):  
Chemical Inhibition ◽  
Dehydroquinate Synthase
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