Chemical inhibition of dehydroquinate synthase

1989 ◽  
Vol 111 (5) ◽  
pp. 1861-1866 ◽  
Author(s):  
S. Myrvold ◽  
L. M. Reimer ◽  
D. L. Pompliano ◽  
J. W. Frost
Keyword(s):  
Chemical Inhibition ◽  
Dehydroquinate Synthase

Probing lethal metabolic perturbations in plants with chemical inhibition of dehydroquinate synthase

1989 ◽  
Vol 111 (5) ◽  
pp. 1866-1871 ◽  
Author(s):  
D. L. Pompliano ◽  
L. M. Reimer ◽  
S. Myrvold ◽  
J. W. Frost
Keyword(s):  
Chemical Inhibition ◽  
Dehydroquinate Synthase

ChemInform Abstract: Probing Lethal Metabolic Perturbations in Plants with Chemical Inhibition of Dehydroquinate Synthase.

ChemInform ◽  
1989 ◽  
Vol 20 (23) ◽  
Author(s):  
D. L. POMPLIANO ◽  
L. M. REIMER ◽  
S. MYRVOLD ◽  
J. W. FROST
Keyword(s):  
Chemical Inhibition ◽  
Dehydroquinate Synthase

ChemInform Abstract: Chemical Inhibition of Dehydroquinate Synthase.

ChemInform ◽  
1989 ◽  
Vol 20 (23) ◽  
Author(s):  
S. MYRVOLD ◽  
L. M. REIMER ◽  
D. L. POMPLIANO ◽  
J. W. FROST
Keyword(s):  
Chemical Inhibition ◽  
Dehydroquinate Synthase

scholarly journals Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sivamoke Dissook ◽  
Tomohisa Kuzuyama ◽  
Yuri Nishimoto ◽  
Shigeru Kitani ◽  
Sastia Putri ◽  
...  
Keyword(s):  
Yarrowia Lipolytica ◽  
Oleaginous Yeast ◽  
Isoprenoid Biosynthesis ◽  
Mep Pathway ◽  
Authentic Standard ◽  
Chemical Inhibition ◽  
Chromatographic Peaks ◽  
Methyl Erythritol Phosphate ◽  
Limiting Condition ◽  
Yeast Yarrowia Lipolytica

AbstractMethyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia lipolytica, in which one of the chromatographic peaks was annotated as MEP when cultivated in the nitrogen limiting condition. This finding raised an interesting hypothesis of whether Y. lipolytica utilizes the MEP pathway for isoprenoid biosynthesis or not, because there is no report of yeast harboring the MEP pathway. Three independent approaches were used to investigate the existence of the MEP pathway in Y. lipolytica; the spiking of the authentic standard, the MEP pathway inhibitor, and the 13C labeling incorporation analysis. The study suggested that the mevalonate and MEP pathways co-exist in Y. lipolytica and the nitrogen limiting condition triggers the utilization of the MEP pathway in Y. lipolytica.

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