scholarly journals RecQ Helicases Function in Development, DNA Repair, and Gene Targeting in Physcomitrella patens

2018 ◽  
Vol 30 (3) ◽  
pp. 717-736 ◽  
Author(s):  
Gertrud Wiedemann ◽  
Nico van Gessel ◽  
Fabian Köchl ◽  
Lisa Hunn ◽  
Katrin Schulze ◽  
...  
Keyword(s):  
Dna Repair ◽  
Gene Targeting ◽  
Physcomitrella Patens ◽  
Recq Helicases

scholarly journals The Gene Targeting Approach of Small Fragment Homologous Replacement (SFHR) Alters the Expression Patterns of DNA Repair and Cell Cycle Control Genes

2016 ◽  
Vol 5 ◽  
pp. e304 ◽  
Author(s):  
Silvia Pierandrei ◽  
Andrea Luchetti ◽  
Massimo Sanchez ◽  
Giuseppe Novelli ◽  
Federica Sangiuolo ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Gene Targeting ◽  
Cell Cycle Control ◽  
Expression Patterns ◽  
Small Fragment

scholarly journals RecQ helicases in DNA repair and cancer targets

2020 ◽  
Vol 64 (5) ◽  
pp. 819-830
Author(s):  
Joseph A. Newman ◽  
Opher Gileadi
Keyword(s):  
Dna Repair ◽  
Small Molecules ◽  
Atp Hydrolysis ◽  
Cancer Therapeutics ◽  
Genome Integrity ◽  
Mechanistic Study ◽  
Synthetic Lethal ◽  
Recq Helicases ◽  
Repair Pathways ◽  
Higher Eukaryotes

Abstract Helicases are enzymes that use the energy derived from ATP hydrolysis to catalyze the unwinding of DNA or RNA. The RecQ family of helicases is conserved through evolution from prokaryotes to higher eukaryotes and plays important roles in various DNA repair pathways, contributing to the maintenance of genome integrity. Despite their roles as general tumor suppressors, there is now considerable interest in exploiting RecQ helicases as synthetic lethal targets for the development of new cancer therapeutics. In this review, we summarize the latest developments in the structural and mechanistic study of RecQ helicases and discuss their roles in various DNA repair pathways. Finally, we consider the potential to exploit RecQ helicases as therapeutic targets and review the recent progress towards the development of small molecules targeting RecQ helicases as cancer therapeutics.

scholarly journals MRE11 and RAD50, but not NBS1, are essential for gene targeting in the moss Physcomitrella patens

2011 ◽  
Vol 40 (8) ◽  
pp. 3496-3510 ◽  
Author(s):  
Yasuko Kamisugi ◽  
Didier G. Schaefer ◽  
Jaroslav Kozak ◽  
Florence Charlot ◽  
Nathalie Vrielynck ◽  
...  
Keyword(s):  
Gene Targeting ◽  
Physcomitrella Patens

scholarly journals Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging

2008 ◽  
Vol 10 (3) ◽  
pp. 235-252 ◽  
Author(s):  
Dharmendra Kumar Singh ◽  
Byungchan Ahn ◽  
Vilhelm A. Bohr
Keyword(s):  
Dna Repair ◽  
Genomic Stability ◽  
Recq Helicases
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