scholarly journals Dual Role of the Histone Variant H2A.Z in Transcriptional Regulation of Stress-Response Genes

2017 ◽  
Vol 29 (4) ◽  
pp. 791-807 ◽  
Author(s):  
Weronika Sura ◽  
Michał Kabza ◽  
Wojciech M. Karlowski ◽  
Tomasz Bieluszewski ◽  
Marta Kus-Slowinska ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Stress Response ◽  
Dual Role ◽  
Histone Variant ◽  
Stress Response Genes

scholarly journals Dual Role of Insulin in Transcriptional Regulation of the Acute Phase Reactant Ceruloplasmin

2002 ◽  
Vol 277 (31) ◽  
pp. 27903-27911 ◽  
Author(s):  
Vasudevan Seshadri ◽  
Paul L. Fox ◽  
Chinmay K. Mukhopadhyay
Keyword(s):  
Transcriptional Regulation ◽  
Acute Phase ◽  
Acute Phase Reactant ◽  
Dual Role ◽  
Phase Reactant

scholarly journals THE ROLE OF TRANSCRIPTION FACTORS DFOXO, DSIR2 AND HSP70 IN LIFESPAN ALTERATION OF DROSOPHILA MELANOGASTER IN DIFFERENT LIGHT CONDITIONS

2010 ◽  
Vol 8 (3) ◽  
pp. 67-80 ◽  
Author(s):  
Aleksey A Moskalev ◽  
Olga A Malysheva
Keyword(s):  
Drosophila Melanogaster ◽  
Transcription Factors ◽  
Stress Response ◽  
Life Span ◽  
Light Regime ◽  
Light Conditions ◽  
Wild Type ◽  
Stress Response Genes ◽  
Significant Difference

It was investigated the role of stress-response genes (dFOXO, dSir2, Hsp70) in regulation of life span of Drosophila in response to light regime alteration. It was revealed the FOXO-dependant mechanism of lifespan increasing at darkness conditions. The distance of lifespan of FOXO homozygous mutants at different light conditions were absent 3 times from 4 times. It was shown, that homozygotes with deletion of dSir2 have more significant difference between lifespan at standard light and darkness conditions with comparing to wild type and heterozygous strain. The same tendency was also detected the in the strains with Hsp70 deletions. It was produced the evidences of two mechanisms of light regime influence on lifespan: metabolism intensification at light conditions and neuroendocrine-determinated lifespan increasing at darkness conditions.

scholarly journals Dual role of the integrated stress response in medulloblastoma tumorigenesis

Oncotarget ◽  
2016 ◽  
Vol 7 (39) ◽  
pp. 64124-64135 ◽  
Author(s):  
Sarrabeth Stone ◽  
Yeung Ho ◽  
Xiting Li ◽  
Stephanie Jamison ◽  
Heather P. Harding ◽  
...  
Keyword(s):  
Stress Response ◽  
Dual Role ◽  
Integrated Stress Response

scholarly journals Dual Role of cAMP in the Transcriptional Regulation of Multidrug Resistance-Associated Protein 4 (MRP4) in Pancreatic Adenocarcinoma Cell Lines

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120651 ◽  
Author(s):  
Alejandro Carozzo ◽  
Federico Diez ◽  
Natalia Gomez ◽  
Maia Cabrera ◽  
Carina Shayo ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Multidrug Resistance ◽  
Pancreatic Adenocarcinoma ◽  
Cell Lines ◽  
Dual Role ◽  
Adenocarcinoma Cell

scholarly journals Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes

2018 ◽  
Vol 131 (9) ◽  
pp. jcs204750 ◽  
Author(s):  
Peter Hoch-Kraft ◽  
Robin White ◽  
Stefan Tenzer ◽  
Eva-Maria Krämer-Albers ◽  
Jacqueline Trotter ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Rna Helicase ◽  
Dual Role ◽  
Post Transcriptional Regulation

scholarly journals Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene

2007 ◽  
Vol 35 (4) ◽  
pp. 1245-1256 ◽  
Author(s):  
S. Renaud ◽  
D. Loukinov ◽  
Z. Abdullaev ◽  
I. Guilleret ◽  
F. T. Bosman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Transcriptional Regulation ◽  
Dual Role ◽  
Ctcf Binding ◽  
Htert Gene ◽  
Binding Regions

scholarly journals Induction of heme oxygenase-1 and heat shock protein 70 in rat hepatocytes: The role of calcium signaling

2007 ◽  
Vol 12 (1) ◽  
Author(s):  
Malte Silomon ◽  
Inge Bauer ◽  
Michael Bauer ◽  
Julia Nolting ◽  
Markus Paxian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stress Response ◽  
Heat Shock ◽  
Heme Oxygenase ◽  
Rat Hepatocytes ◽  
Glutathione Depletion ◽  
Heme Oxygenase 1 ◽  
Hsp70 Gene ◽  
Stress Response Genes

AbstractStress response genes including heat shock proteins are induced under a variety of conditions to confer cellular protection. This study investigated the role of calcium signaling in the induction of two stress response genes, heme oxygenase-1/hsp32 and hsp70, in isolated rat hepatocytes. Both genes were induced by cellular glutathione depletion. This induction could be inhibited by BAPTA-AM. Culturing in a calcium-free medium prevented the induction of hsp70 gene expression after glutathione depletion without affecting heme oxygenase-1 gene expression. Thapsigargin increased the gene expression of heme oxygenase-1 but not that of hsp70. Thapsigargin-induced heme oxygenase-1 induction was completely inhibited by BAPTA-AM. Incubation with the Ca2+-ionophore A23187 augmented heme oxygenase-1 (two-fold) and hsp70 (5.2-fold) mRNA levels. Our data suggests a significant role of Ca2+-dependent pathways in the induction of the two stress genes. An increase in the cytoplasmic Ca2+ activity seems to play a key role in the cascade of signaling leading to the induction of the two genes. However, the source of Ca2+ that fluxes into the cytoplasm seems to be different. Our data provides evidence for a compartmentalization of calcium fluxes, i.e. the Ca2+ flux from intracellular stores (e.g. the endoplasmic reticulum) plays a major role in the induction of heme oxygenase-1. By contrast, Ca2+ flux from the extracellular medium seems to be a mechanism initiating the cellular signaling cascade leading to hsp70 gene induction.

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