scholarly journals Temperature-Dependent Phase Behavior of Phosphatidylglycerols from Chilling-Sensitive and Chilling-Resistant Plants

1984 ◽  
Vol 74 (4) ◽  
pp. 1016-1024 ◽  
Author(s):  
Norio Murata ◽  
Jun Yamaya
Science ◽  
2020 ◽  
Vol 367 (6478) ◽  
pp. 694-699 ◽  
Author(s):  
Erik W. Martin ◽  
Alex S. Holehouse ◽  
Ivan Peran ◽  
Mina Farag ◽  
J. Jeremias Incicco ◽  
...  

Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an integrative biophysical approach that includes nuclear magnetic resonance spectroscopy, small-angle x-ray scattering, and multiscale simulations, we have uncovered sequence features that determine the overall phase behavior of PLDs. We show that the numbers (valence) of aromatic residues in PLDs determine the extent of temperature-dependent compaction of individual molecules in dilute solutions. The valence of aromatic residues also determines full binodals that quantify concentrations of PLDs within coexisting dilute and dense phases as a function of temperature. We also show that uniform patterning of aromatic residues is a sequence feature that promotes LLPS while inhibiting aggregation. Our findings lead to the development of a numerical stickers-and-spacers model that enables predictions of full binodals of PLDs from their sequences.


Langmuir ◽  
2010 ◽  
Vol 26 (5) ◽  
pp. 3003-3007 ◽  
Author(s):  
Aaron P. R. Eberle ◽  
Norman J. Wagner ◽  
Bulent Akgun ◽  
Sushil K. Satija

Langmuir ◽  
2007 ◽  
Vol 23 (4) ◽  
pp. 1880-1887 ◽  
Author(s):  
Silke Steffens ◽  
Udo Höweler ◽  
Tim Jödicke ◽  
Jens Oldendorf ◽  
Rainer Rudert ◽  
...  

Polymer ◽  
2001 ◽  
Vol 42 (5) ◽  
pp. 2193-2199 ◽  
Author(s):  
Jyh-Luen Chen ◽  
Feng-Chih Chang

1990 ◽  
Vol 93 (1) ◽  
pp. 767-773 ◽  
Author(s):  
Ralph G. Nuzzo ◽  
Eileen M. Korenic ◽  
Lawrence H. Dubois

2013 ◽  
Vol 104 (2) ◽  
pp. 246a-247a
Author(s):  
Gulcin Pekkurnaz ◽  
Tomohiro Kimura ◽  
Sierra C. Germeyan ◽  
Jessica Zimmerberg-Helms ◽  
James Loewke ◽  
...  

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