scholarly journals Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis

2016 ◽  
Vol 171 (4) ◽  
pp. 2432-2444 ◽  
Author(s):  
Somnuk Bunsupa ◽  
Kousuke Hanada ◽  
Akira Maruyama ◽  
Kaori Aoyagi ◽  
Kana Komatsu ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Functional Characterization ◽  
Alkaloid Biosynthesis ◽  
Lycopodium Alkaloid

scholarly journals Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

PLoS Genetics ◽  
2010 ◽  
Vol 6 (2) ◽  
pp. e1000857 ◽  
Author(s):  
Sebastian Grönke ◽  
David-Francis Clarke ◽  
Susan Broughton ◽  
T. Daniel Andrews ◽  
Linda Partridge
Keyword(s):  
Molecular Evolution ◽  
Functional Characterization

Molecular evolution and functional characterization of SOCS3a and SOCS3b in miiuy croaker (Miichthys miiuy)

2020 ◽  
Vol 110 ◽  
pp. 103723
Author(s):  
Ruixuan Huo ◽  
Qing Chu ◽  
Xueyan Zhao ◽  
Xuezhu Liu ◽  
Tianjun Xu
Keyword(s):  
Molecular Evolution ◽  
Functional Characterization ◽  
Miichthys Miiuy

Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates

2011 ◽  
Vol 343 (3) ◽  
pp. 475-481 ◽  
Author(s):  
Kazuyoshi Ukena ◽  
Hubert Vaudry ◽  
Jérôme Leprince ◽  
Kazuyoshi Tsutsui
Keyword(s):  
Molecular Evolution ◽  
Functional Characterization ◽  
Orexigenic Peptide

scholarly journals Cloning, molecular evolution and functional characterization of ZmbHLH16, the maize ortholog of OsTIP2 (OsbHLH142)

Biology Open ◽  
2017 ◽  
Vol 6 (11) ◽  
pp. 1654-1663 ◽  
Author(s):  
Yongming Liu ◽  
Jia Li ◽  
Gui Wei ◽  
Yonghao Sun ◽  
Yanli Lu ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Functional Characterization

scholarly journals Transcription Factors in Alkaloid Engineering

Biomolecules ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1719
Author(s):  
Yasuyuki Yamada ◽  
Fumihiko Sato
Keyword(s):  
Transcriptional Regulation ◽  
Transcription Factors ◽  
Functional Characterization ◽  
Genome Structure ◽  
Metabolite Identification ◽  
Secondary Compounds ◽  
Biologically Active ◽  
Tissue Cell ◽  
Alkaloid Biosynthesis

Plants produce a large variety of low-molecular-weight and specialized secondary compounds. Among them, nitrogen-containing alkaloids are the most biologically active and are often used in the pharmaceutical industry. Although alkaloid chemistry has been intensively investigated, characterization of alkaloid biosynthesis, including biosynthetic enzyme genes and their regulation, especially the transcription factors involved, has been relatively delayed, since only a limited number of plant species produce these specific types of alkaloids in a tissue/cell-specific or developmental-specific manner. Recent advances in molecular biology technologies, such as RNA sequencing, co-expression analysis of transcripts and metabolites, and functional characterization of genes using recombinant technology and cutting-edge technology for metabolite identification, have enabled a more detailed characterization of alkaloid pathways. Thus, transcriptional regulation of alkaloid biosynthesis by transcription factors, such as basic helix–loop–helix (bHLH), APETALA2/ethylene-responsive factor (AP2/ERF), and WRKY, is well elucidated. In addition, jasmonate signaling, an important cue in alkaloid biosynthesis, and its cascade, interaction of transcription factors, and post-transcriptional regulation are also characterized and show cell/tissue-specific or developmental regulation. Furthermore, current sequencing technology provides more information on the genome structure of alkaloid-producing plants with large and complex genomes, for genome-wide characterization. Based on the latest information, we discuss the application of transcription factors in alkaloid engineering.

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