scholarly journals Photoelectron Diffraction Imaging of a Molecular Breakup Using an X-Ray Free-Electron Laser

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Gregor Kastirke ◽  
Markus S. Schöffler ◽  
Miriam Weller ◽  
Jonas Rist ◽  
Rebecca Boll ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
X Ray ◽  
Photoelectron Diffraction ◽  
Diffraction Imaging

scholarly journals Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution

Nanoscale ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 2820-2824 ◽  
Author(s):  
Chi-Feng Huang ◽  
Keng S. Liang ◽  
Tsui-Ling Hsu ◽  
Tsung-Tse Lee ◽  
Yi-Yun Chen ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
X Ray ◽  
Individual Drug ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging

Coherent diffraction imaging (CDI) with X-ray free electron laser (X-FEL) detected individual blank (left) and drug containing (right, with Doxorubicin nanorod) liposome nanoparticles in solution.

scholarly journals The free-electron laser FLASH

2015 ◽  
Vol 3 ◽  
Author(s):  
Siegfried Schreiber ◽  
Bart Faatz
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Extreme Ultraviolet ◽  
Laser Flash ◽  
Single Shot ◽  
Short Pulses ◽  
X Ray ◽  
Pump And Probe ◽  
User Facility ◽  
Diffraction Imaging

FLASH at DESY, Hamburg, Germany is the first free-electron laser (FEL) operating in the extreme ultraviolet (EUV) and soft x-ray wavelength range. FLASH is a user facility providing femtosecond short pulses with an unprecedented peak and average brilliance, opening new scientific opportunities in many disciplines. The first call for user experiments has been launched in 2005. The FLASH linear accelerator is based on TESLA superconducting technology, providing several thousands of photon pulses per second to user experiments. Probing femtosecond-scale dynamics in atomic and molecular reactions using, for instance, a combination of x-ray and optical pulses in a pump and probe arrangement, as well as single-shot diffraction imaging of biological objects and molecules, are typical experiments performed at the facility. We give an overview of the FLASH facility, and describe the basic principles of the accelerator. Recently, FLASH has been extended by a second undulator beamline (FLASH2) operated in parallel to the first beamline, extending the capacity of the facility by a factor of two.

Coherent Diffraction Imaging Analysis of Shape-Controlled Nanoparticles with Focused Hard X-ray Free-Electron Laser Pulses

Nano Letters ◽  
2013 ◽  
Vol 13 (12) ◽  
pp. 6028-6032 ◽  
Author(s):  
Yukio Takahashi ◽  
Akihiro Suzuki ◽  
Nobuyuki Zettsu ◽  
Tomotaka Oroguchi ◽  
Yuki Takayama ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Laser Pulses ◽  
Imaging Analysis ◽  
X Ray ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging ◽  
Shape Controlled

scholarly journals Data processing software suiteSITENNOfor coherent X-ray diffraction imaging using the X-ray free-electron laser SACLA

2014 ◽  
Vol 21 (3) ◽  
pp. 600-612 ◽  
Author(s):  
Yuki Sekiguchi ◽  
Tomotaka Oroguchi ◽  
Yuki Takayama ◽  
Masayoshi Nakasako
Keyword(s):  
Data Processing ◽  
Free Electron ◽  
Free Electron Laser ◽  
Single Shot ◽  
X Ray Diffraction ◽  
X Ray ◽  
Custom Made ◽  
Diffraction Imaging ◽  
Diffraction Patterns ◽  
Ccd Detectors

Coherent X-ray diffraction imaging is a promising technique for visualizing the structures of non-crystalline particles with dimensions of micrometers to sub-micrometers. Recently, X-ray free-electron laser sources have enabled efficient experiments in the `diffraction before destruction' scheme. Diffraction experiments have been conducted at SPring-8 Angstrom Compact free-electron LAser (SACLA) using the custom-made diffraction apparatus KOTOBUKI-1 and two multiport CCD detectors. In the experiments, ten thousands of single-shot diffraction patterns can be collected within several hours. Then, diffraction patterns with significant levels of intensity suitable for structural analysis must be found, direct-beam positions in diffraction patterns determined, diffraction patterns from the two CCD detectors merged, and phase-retrieval calculations for structural analyses performed. A software suite namedSITENNOhas been developed to semi-automatically apply the four-step processing to a huge number of diffraction data. Here, details of the algorithm used in the suite are described and the performance for approximately 9000 diffraction patterns collected from cuboid-shaped copper oxide particles reported. Using theSITENNOsuite, it is possible to conduct experiments with data processing immediately after the data collection, and to characterize the size distribution and internal structures of the non-crystalline particles.

scholarly journals Specimen preparation for cryogenic coherent X-ray diffraction imaging of biological cells and cellular organelles by using the X-ray free-electron laser at SACLA

2016 ◽  
Vol 23 (4) ◽  
pp. 975-989 ◽  
Author(s):  
Amane Kobayashi ◽  
Yuki Sekiguchi ◽  
Tomotaka Oroguchi ◽  
Koji Okajima ◽  
Asahi Fukuda ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
X Ray Diffraction ◽  
X Ray ◽  
Internal Structures ◽  
Thin Membranes ◽  
Diffraction Imaging ◽  
Diffraction Patterns ◽  
Cellular Organelles

Coherent X-ray diffraction imaging (CXDI) allows internal structures of biological cells and cellular organelles to be analyzed. CXDI experiments have been conducted at 66 K for frozen-hydrated biological specimens at the SPring-8 Angstrom Compact Free-Electron Laser facility (SACLA). In these cryogenic CXDI experiments using X-ray free-electron laser (XFEL) pulses, specimen particles dispersed on thin membranes of specimen disks are transferred into the vacuum chamber of a diffraction apparatus. Because focused single XFEL pulses destroy specimen particles at the atomic level, diffraction patterns are collected through raster scanning the specimen disks to provide fresh specimen particles in the irradiation area. The efficiency of diffraction data collection in cryogenic experiments depends on the quality of the prepared specimens. Here, detailed procedures for preparing frozen-hydrated biological specimens, particularly thin membranes and devices developed in our laboratory, are reported. In addition, the quality of the frozen-hydrated specimens are evaluated by analyzing the characteristics of the collected diffraction patterns. Based on the experimental results, the internal structures of the frozen-hydrated specimens and the future development for efficient diffraction data collection are discussed.

scholarly journals Photoelectron diffraction from laser-aligned molecules with X-ray free-electron laser pulses

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Kyo Nakajima ◽  
Takahiro Teramoto ◽  
Hiroshi Akagi ◽  
Takashi Fujikawa ◽  
Takuya Majima ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Laser Pulses ◽  
X Ray ◽  
Photoelectron Diffraction

scholarly journals Structure determination of molecules in an alignment laser field by femtosecond photoelectron diffraction using an X-ray free-electron laser

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shinichirou Minemoto ◽  
Takahiro Teramoto ◽  
Hiroshi Akagi ◽  
Takashi Fujikawa ◽  
Takuya Majima ◽  
...  
Keyword(s):  
Structure Determination ◽  
Free Electron ◽  
Free Electron Laser ◽  
Laser Field ◽  
X Ray ◽  
Photoelectron Diffraction

scholarly journals Focusing X-ray free-electron laser pulses using Kirkpatrick–Baez mirrors at the NCI hutch of the PAL-XFEL

2018 ◽  
Vol 25 (1) ◽  
pp. 289-292 ◽  
Author(s):  
Jangwoo Kim ◽  
Hyo-Yun Kim ◽  
Jaehyun Park ◽  
Sangsoo Kim ◽  
Sunam Kim ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Laser Pulses ◽  
Mirror System ◽  
X Rays ◽  
X Ray ◽  
Fixed Sample ◽  
Scattering Geometry ◽  
Diffraction Imaging ◽  
Pal Xfel

The Pohang Accelerator Laboratory X-ray Free-Electron Laser (PAL-XFEL) is a recently commissioned X-ray free-electron laser (XFEL) facility that provides intense ultrashort X-ray pulses based on the self-amplified spontaneous emission process. The nano-crystallography and coherent imaging (NCI) hutch with forward-scattering geometry is located at the hard X-ray beamline of the PAL-XFEL and provides opportunities to perform serial femtosecond crystallography and coherent X-ray diffraction imaging. To produce intense high-density XFEL pulses at the interaction positions between the X-rays and various samples, a microfocusing Kirkpatrick–Baez (KB) mirror system that includes an ultra-precision manipulator has been developed. In this paper, the design of a KB mirror system that focuses the hard XFEL beam onto a fixed sample point of the NCI hutch, which is positioned along the hard XFEL beamline, is described. The focusing system produces a two-dimensional focusing beam at approximately 2 µm scale across the 2–11 keV photon energy range. XFEL pulses of 9.7 keV energy were successfully focused onto an area of size 1.94 µm × 2.08 µm FWHM.

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