scholarly journals Free-electron-laser coherent diffraction images of individual drug-carrying liposome particles in solution

Nanoscale ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 2820-2824 ◽  
Author(s):  
Chi-Feng Huang ◽  
Keng S. Liang ◽  
Tsui-Ling Hsu ◽  
Tsung-Tse Lee ◽  
Yi-Yun Chen ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
X Ray ◽  
Individual Drug ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging

Coherent diffraction imaging (CDI) with X-ray free electron laser (X-FEL) detected individual blank (left) and drug containing (right, with Doxorubicin nanorod) liposome nanoparticles in solution.

Coherent Diffraction Imaging Analysis of Shape-Controlled Nanoparticles with Focused Hard X-ray Free-Electron Laser Pulses

Nano Letters ◽  
2013 ◽  
Vol 13 (12) ◽  
pp. 6028-6032 ◽  
Author(s):  
Yukio Takahashi ◽  
Akihiro Suzuki ◽  
Nobuyuki Zettsu ◽  
Tomotaka Oroguchi ◽  
Yuki Takayama ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Laser Pulses ◽  
Imaging Analysis ◽  
X Ray ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging ◽  
Shape Controlled

scholarly journals Single-pulse enhanced coherent diffraction imaging of bacteria with an X-ray free-electron laser

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Jiadong Fan ◽  
Zhibin Sun ◽  
Yaling Wang ◽  
Jaehyun Park ◽  
Sunam Kim ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Single Pulse ◽  
X Ray ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging

Correction to Coherent Diffraction Imaging Analysis of Shape-Controlled Nanoparticles with Focused Hard X-ray Free-Electron Laser Pulses

Nano Letters ◽  
2014 ◽  
Vol 14 (4) ◽  
pp. 2231-2231
Author(s):  
Yukio Takahashi ◽  
Akihiro Suzuki ◽  
Nobuyuki Zettsu ◽  
Tomotaka Oroguchi ◽  
Yuki Takayama ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Laser Pulses ◽  
Imaging Analysis ◽  
X Ray ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging ◽  
Shape Controlled

scholarly journals Towards Realistic Simulations of Macromolecules Irradiated under the Conditions of Coherent Diffraction Imaging with an X-ray Free-Electron Laser

Photonics ◽  
2015 ◽  
Vol 2 (1) ◽  
pp. 256-269 ◽  
Author(s):  
Beata Ziaja ◽  
Zoltan Jurek ◽  
Nikita Medvedev ◽  
Vikrant Saxena ◽  
Sang-Kil Son ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
X Ray ◽  
Coherent Diffraction Imaging ◽  
Diffraction Imaging

scholarly journals Photoelectron Diffraction Imaging of a Molecular Breakup Using an X-Ray Free-Electron Laser

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Gregor Kastirke ◽  
Markus S. Schöffler ◽  
Miriam Weller ◽  
Jonas Rist ◽  
Rebecca Boll ◽  
...  
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
X Ray ◽  
Photoelectron Diffraction ◽  
Diffraction Imaging

scholarly journals The free-electron laser FLASH

2015 ◽  
Vol 3 ◽  
Author(s):  
Siegfried Schreiber ◽  
Bart Faatz
Keyword(s):  
Free Electron ◽  
Free Electron Laser ◽  
Extreme Ultraviolet ◽  
Laser Flash ◽  
Single Shot ◽  
Short Pulses ◽  
X Ray ◽  
Pump And Probe ◽  
User Facility ◽  
Diffraction Imaging

FLASH at DESY, Hamburg, Germany is the first free-electron laser (FEL) operating in the extreme ultraviolet (EUV) and soft x-ray wavelength range. FLASH is a user facility providing femtosecond short pulses with an unprecedented peak and average brilliance, opening new scientific opportunities in many disciplines. The first call for user experiments has been launched in 2005. The FLASH linear accelerator is based on TESLA superconducting technology, providing several thousands of photon pulses per second to user experiments. Probing femtosecond-scale dynamics in atomic and molecular reactions using, for instance, a combination of x-ray and optical pulses in a pump and probe arrangement, as well as single-shot diffraction imaging of biological objects and molecules, are typical experiments performed at the facility. We give an overview of the FLASH facility, and describe the basic principles of the accelerator. Recently, FLASH has been extended by a second undulator beamline (FLASH2) operated in parallel to the first beamline, extending the capacity of the facility by a factor of two.

scholarly journals Data processing software suiteSITENNOfor coherent X-ray diffraction imaging using the X-ray free-electron laser SACLA

2014 ◽  
Vol 21 (3) ◽  
pp. 600-612 ◽  
Author(s):  
Yuki Sekiguchi ◽  
Tomotaka Oroguchi ◽  
Yuki Takayama ◽  
Masayoshi Nakasako
Keyword(s):  
Data Processing ◽  
Free Electron ◽  
Free Electron Laser ◽  
Single Shot ◽  
X Ray Diffraction ◽  
X Ray ◽  
Custom Made ◽  
Diffraction Imaging ◽  
Diffraction Patterns ◽  
Ccd Detectors

Coherent X-ray diffraction imaging is a promising technique for visualizing the structures of non-crystalline particles with dimensions of micrometers to sub-micrometers. Recently, X-ray free-electron laser sources have enabled efficient experiments in the `diffraction before destruction' scheme. Diffraction experiments have been conducted at SPring-8 Angstrom Compact free-electron LAser (SACLA) using the custom-made diffraction apparatus KOTOBUKI-1 and two multiport CCD detectors. In the experiments, ten thousands of single-shot diffraction patterns can be collected within several hours. Then, diffraction patterns with significant levels of intensity suitable for structural analysis must be found, direct-beam positions in diffraction patterns determined, diffraction patterns from the two CCD detectors merged, and phase-retrieval calculations for structural analyses performed. A software suite namedSITENNOhas been developed to semi-automatically apply the four-step processing to a huge number of diffraction data. Here, details of the algorithm used in the suite are described and the performance for approximately 9000 diffraction patterns collected from cuboid-shaped copper oxide particles reported. Using theSITENNOsuite, it is possible to conduct experiments with data processing immediately after the data collection, and to characterize the size distribution and internal structures of the non-crystalline particles.

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