Lehmann rotation of cholesteric droplets: Role of the sample thickness and of the concentration of chiral molecules

2015 ◽  
Vol 91 (3) ◽  
Author(s):  
Patrick Oswald ◽  
Guilhem Poy
Keyword(s):  
Sample Thickness ◽  
Chiral Molecules

scholarly journals Chiral Magneto-Electrochemistry

2018 ◽  
Vol 4 (3) ◽  
pp. 36 ◽  
Author(s):  
Anup Kumar ◽  
Prakash Mondal ◽  
Claudio Fontanesi
Keyword(s):  
Magnetic Field ◽  
Experimental Studies ◽  
Spin Accumulation ◽  
Chiral Molecules ◽  
Electrochemical System ◽  
Ferromagnetic Electrodes ◽  
Spin Polarized ◽  
The Magnetic Field ◽  
Research Domain

Magneto-electrochemistry (MEC) is a unique paradigm in science, where electrochemical experiments are carried out as a function of an applied magnetic field, creating a new horizon of potential scientific interest and technological applications. Over time, detailed understanding of this research domain was developed to identify and rationalize the possible effects exerted by a magnetic field on the various microscopic processes occurring in an electrochemical system. Notably, until a few years ago, the role of spin was not taken into account in the field of magneto-electrochemistry. Remarkably, recent experimental studies reveal that electron transmission through chiral molecules is spin selective and this effect has been referred to as the chiral-induced spin selectivity (CISS) effect. Spin-dependent electrochemistry originates from the implementation of the CISS effect in electrochemistry, where the magnetic field is used to obtain spin-polarized currents (using ferromagnetic electrodes) or, conversely, a magnetic field is obtained as the result of spin accumulation.

scholarly journals A hidden catalysis: metal-, and organocatalyst-free one-pot assembly of chiral aza-tricyclic molecules containing six contiguous stereocenters

2020 ◽  
Author(s):  
Dung Do
Keyword(s):  
Chemical Space ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Chiral Molecules ◽  
One Pot ◽  
Complex Molecules ◽  
Chiral Complex ◽  
Enamine Catalysis ◽  
Daunting Challenge

<p></p><p>Chiral molecules with their defined 3-D structures are of paramount importance for the study of chemical biology and drug discovery. Having rich structural diversity and unique stereoisomerism, chiral molecules offer a large chemical space that can be explored for the design of new therapeutic agents.<sup>1</sup> In practice, chiral architectures are usually prepared from organometallic and organocatalytic processes where a transition metal or an organocatalyst is tailor-made for a desired reaction. As a result, developing a method that enables rapid assembly of chiral complex molecules under a metal- and organocatalyst-free condition represents a daunting challenge. Here we developed a straightforward one-pot procedure to create a chiral 3-D structure from 2-D structures and an amino acid without any chiral catalyst. The center of this research is the design of a <a>special chiral spiroimidazolidinone cyclohexadienone intermediate</a>, a merger of a chiral reactive substrate with multiple nucleophillic/electrophillic sites and a transient organocatalyst. <a>This unique substrate-catalyst (“sub-catalyst”) dual role of the intermediate was displayed in its aza-Michael/Michael cascade reaction with an </a>α,β-unsaturated aldehyde under an iminium/enamine catalysis. <a>The enhanced co-ordinational proximity of the chiral substrate and catalyst</a> in the transition state resulted in a substantial steric discrimination and an excellent overall diastereoselectivity. Aza-tricylic molecules with six contiguous stereocenters were assembled from <i>N</i>-alkylated aminophenols, α,β-unsaturated aldehydes and chiral α-amino acids under a hidden “sub-catalysis” where the strategically produced “sub-catalyst” does not present in initial components of the reaction. The success of this methodology will pave the way for many efficient preparations of chiral complex molecules.</p><br><p></p>

scholarly journals A hidden catalysis: metal-, and organocatalyst-free one-pot assembly of chiral aza-tricyclic molecules containing six contiguous stereocenters

2020 ◽  
Author(s):  
Dung Do
Keyword(s):  
Chemical Space ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Chiral Molecules ◽  
One Pot ◽  
Complex Molecules ◽  
Chiral Complex ◽  
Enamine Catalysis ◽  
Daunting Challenge

<p></p><p>Chiral molecules with their defined 3-D structures are of paramount importance for the study of chemical biology and drug discovery. Having rich structural diversity and unique stereoisomerism, chiral molecules offer a large chemical space that can be explored for the design of new therapeutic agents.<sup>1</sup> In practice, chiral architectures are usually prepared from organometallic and organocatalytic processes where a transition metal or an organocatalyst is tailor-made for a desired reaction. As a result, developing a method that enables rapid assembly of chiral complex molecules under a metal- and organocatalyst-free condition represents a daunting challenge. Here we developed a straightforward one-pot procedure to create a chiral 3-D structure from 2-D structures and an amino acid without any chiral catalyst. The center of this research is the design of a <a>special chiral spiroimidazolidinone cyclohexadienone intermediate</a>, a merger of a chiral reactive substrate with multiple nucleophillic/electrophillic sites and a transient organocatalyst. <a>This unique substrate-catalyst (“sub-catalyst”) dual role of the intermediate was displayed in its aza-Michael/Michael cascade reaction with an </a>α,β-unsaturated aldehyde under an iminium/enamine catalysis. <a>The enhanced co-ordinational proximity of the chiral substrate and catalyst</a> in the transition state resulted in a substantial steric discrimination and an excellent overall diastereoselectivity. Aza-tricylic molecules with six contiguous stereocenters were assembled from <i>N</i>-alkylated aminophenols, α,β-unsaturated aldehydes and chiral α-amino acids under a hidden “sub-catalysis” where the strategically produced “sub-catalyst” does not present in initial components of the reaction. The success of this methodology will pave the way for many efficient preparations of chiral complex molecules.</p><br><p></p>

scholarly journals Comment on the Determination of the Polar Anchoring Energy by Capacitance Measurements in Nematic Liquid Crystals

2021 ◽  
Author(s):  
Patrick Oswald
Keyword(s):  
Liquid Crystals ◽  
Sample Thickness ◽  
Dielectric Constants ◽  
Brilliant Yellow ◽  
Voltage Range ◽  
Capacitance Measurements ◽  
A Cell ◽  
Anchoring Energy

Capacitance measurements have been extensively used to measure the anchoring extrapolation length L at a nematic-substrate interface. These measurements are extremely delicate because the value found for L often critically depends on the sample thickness and the voltage range chosen to perform the measurements. Several reasons have been proposed to explain this observation, such as the presence of inhomogeneities in the director distribution on the bounding plates or the variation with the electric field of the dielectric constants. In this paper I propose a new method to measure Lp that takes into account this second effect. This method is more general than that proposed in Murauski et al. Phys. Rev. E 71, 061707 (2005) because it does not assume that the anchoring angle is small and that the anchoring energy is of the Rapini-Papoular form. This method is applied to a cell of 8CB treated for planar unidirectional anchoring by photoalignment with the azobenzene dye Brilliant Yellow. The role of flexoelectric effects and the shape of the anchoring potential are discussed.

scholarly journals Water-promoted Synthesis of Stereoselective Oxazoline-fused Saccharides and Construction for 1, 2-cis Glycosylamines of Multi-modifications of Polyhydroxyl groups

2020 ◽  
Author(s):  
Sanfeng Dong ◽  
Yitian Zhao ◽  
Yulong Shi ◽  
Zhijian Xu ◽  
Jingshan Shen ◽  
...  
Keyword(s):  
Density Functional ◽  
Chiral Molecules ◽  
Functional Theory ◽  
Neighboring Group ◽  
Group Participation ◽  
Glycosidic Bonds ◽  
The Density Functional Theory ◽  
Acidic Conditions ◽  
Neighboring Group Participation

Abstract The multi-modifications of polyhydroxyl groups and the stereoselective formation of 1,2-cis glycosidic bonds are difficult in glycochemistry. Herein we disclosed a concise synthesis of the oxazoline-fused saccharides (oxazolinoses) from acetyl saccharides and benzonitriles under acidic conditions promoted by the stoichiometric water. The oxazolinoses can be easily converted into 1,2-cis glycosylamines with differentiated modifications at 2,3-positions on the saccharide ring in few steps and the 1-NH2 can further be simply transformed to the 1-OH. Oxazolinoses can also be directly used to synthesize complex chiral molecules such as schisandrins. Saccharides screening have shown that the oxazolinoses could be synthesized from various monosaccharides and oligosaccharides. Accordingly, 1-α- or 1-β-1,2-cis glycosylamines can be obtained from different oxazolinoses which are 1,2-cis stereoselectivity controlled by neighboring group participation. The density functional theory (DFT) calculations have revealed the origin of the stereoselectivity and the key role of water.

scholarly journals Comment on the Determination of the Polar Anchoring Energy by Capacitance Measurements in Nematic Liquid Crystals

2021 ◽  
Vol 11 (16) ◽  
pp. 7387
Author(s):  
Patrick Oswald
Keyword(s):  
Sample Thickness ◽  
Dielectric Constants ◽  
Brilliant Yellow ◽  
Voltage Range ◽  
Capacitance Measurements ◽  
A Cell ◽  
Anchoring Energy ◽  
The One

Capacitance measurements have been extensively used to measure the anchoring extrapolation length L at a nematic–substrate interface. These measurements are extremely delicate because the value found for L often critically depends on the sample thickness and the voltage range chosen to perform the measurements. Several reasons have been proposed to explain this observation, such as the presence of inhomogeneities in the director distribution on the bounding plates or the variation with the electric field of the dielectric constants. In this paper, I propose a new method to measure L that takes into account this second effect. This method is more general than the one proposed in Murauski et al. Phys. Rev. E 71, 061707 (2005) because it does not assume that the anchoring angle is small and that the anchoring energy is of the Rapini–Papoular form. This method is applied to a cell of 8CB that is treated for planar unidirectional anchoring by photoalignment with the azobenzene dye Brilliant Yellow. The role of flexoelectric effects and the shape of the anchoring potential are discussed.

An Experimental and Theoretical Study of Jet-Cooled Complexes of Chiral Molecules:  The Role of Dispersive Forces in Chiral Discrimination

1998 ◽  
Vol 102 (1) ◽  
pp. 128-137 ◽  
Author(s):  
K. Le Barbu ◽  
V. Brenner ◽  
Ph. Millié ◽  
F. Lahmani ◽  
A. Zehnacker-Rentien
Keyword(s):  
Theoretical Study ◽  
Chiral Discrimination ◽  
Chiral Molecules

scholarly journals Role of Exchange Interactions in the Magnetic Response and Intermolecular Recognition of Chiral Molecules

Nano Letters ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. 7077-7086 ◽  
Author(s):  
Arezoo Dianat ◽  
Rafael Gutierrez ◽  
Hen Alpern ◽  
Vladimiro Mujica ◽  
Amir Ziv ◽  
...  
Keyword(s):  
Exchange Interactions ◽  
Magnetic Response ◽  
Chiral Molecules ◽  
Intermolecular Recognition
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