scholarly journals Thin-string limit of the 6D stringlike defect model

2001 ◽  
Vol 64 (2) ◽  
Author(s):  
P. Tinyakov ◽  
K. Zuleta
Keyword(s):  
Defect Model ◽  
Thin String

scholarly journals Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xinchen Du ◽  
Le Wu ◽  
Hongyu Yan ◽  
Zhuyan Jiang ◽  
Shilin Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Shape Recovery ◽  
Parenchymal Cell ◽  
Gelatin Sponge ◽  
Defect Model ◽  
Liver Parenchymal Cell ◽  
E Coli ◽  
Tissue Integration ◽  
3D Printed

AbstractDeveloping an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate its anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.

scholarly journals Functional regeneration and repair of tendons using biomimetic scaffolds loaded with recombinant periostin

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yu Wang ◽  
Shanshan Jin ◽  
Dan Luo ◽  
Danqing He ◽  
Chunyan Shi ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Transcriptional Profiling ◽  
Collagen Scaffold ◽  
Defect Model ◽  
Tendon Regeneration ◽  
Biomimetic Scaffolds ◽  
Functional Regeneration

AbstractTendon injuries disrupt the balance between stability and mobility, causing compromised functions and disabilities. The regeneration of mature, functional tendons remains a clinical challenge. Here, we perform transcriptional profiling of tendon developmental processes to show that the extracellular matrix-associated protein periostin (Postn) contributes to the maintenance of tendon stem/progenitor cell (TSPC) functions and promotes tendon regeneration. We show that recombinant periostin (rPOSTN) promotes the proliferation and stemness of TSPCs, and maintains the tenogenic potentials of TSPCs in vitro. We also find that rPOSTN protects TSPCs against functional impairment during long-term passage in vitro. For in vivo tendon formation, we construct a biomimetic parallel-aligned collagen scaffold to facilitate TSPC tenogenesis. Using a rat full-cut Achilles tendon defect model, we demonstrate that scaffolds loaded with rPOSTN promote endogenous TSPC recruitment, tendon regeneration and repair with native-like hierarchically organized collagen fibers. Moreover, newly regenerated tendons show recovery of mechanical properties and locomotion functions.

scholarly journals Electrosprayed naringin-loaded microsphere/SAIB hybrid depots enhance bone formation in a mouse calvarial defect model

Drug Delivery ◽  
2019 ◽  
Vol 26 (1) ◽  
pp. 137-146 ◽  
Author(s):  
Xue Yang ◽  
Huthayfa N.S Almassri ◽  
Qiongyue Zhang ◽  
Yihui Ma ◽  
Dan Zhang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Calvarial Defect ◽  
Defect Model ◽  
Enhance Bone Formation

Events of wound healing/regeneration in the canine supraalveolar periodontal defect model

2013 ◽  
Vol 40 (5) ◽  
pp. 527-541 ◽  
Author(s):  
Douglas P. Dickinson ◽  
Brandon G. Coleman ◽  
Nathan Batrice ◽  
Jaebum Lee ◽  
Komal Koli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Defect Model
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