Events of wound healing/regeneration in the canine supraalveolar periodontal defect model

2013 ◽  
Vol 40 (5) ◽  
pp. 527-541 ◽  
Author(s):  
Douglas P. Dickinson ◽  
Brandon G. Coleman ◽  
Nathan Batrice ◽  
Jaebum Lee ◽  
Komal Koli ◽  
...  
Keyword(s):  
Wound Healing ◽  
Defect Model

scholarly journals Microchannelled alkylated chitosan sponge to treat noncompressible hemorrhages and facilitate wound healing

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xinchen Du ◽  
Le Wu ◽  
Hongyu Yan ◽  
Zhuyan Jiang ◽  
Shilin Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Shape Recovery ◽  
Parenchymal Cell ◽  
Gelatin Sponge ◽  
Defect Model ◽  
Liver Parenchymal Cell ◽  
E Coli ◽  
Tissue Integration ◽  
3D Printed

AbstractDeveloping an anti-infective shape-memory hemostatic sponge able to guide in situ tissue regeneration for noncompressible hemorrhages in civilian and battlefield settings remains a challenge. Here we engineer hemostatic chitosan sponges with highly interconnective microchannels by combining 3D printed microfiber leaching, freeze-drying, and superficial active modification. We demonstrate that the microchannelled alkylated chitosan sponge (MACS) exhibits the capacity for water and blood absorption, as well as rapid shape recovery. We show that compared to clinically used gauze, gelatin sponge, CELOX™, and CELOX™-gauze, the MACS provides higher pro-coagulant and hemostatic capacities in lethally normal and heparinized rat and pig liver perforation wound models. We demonstrate its anti-infective activity against S. aureus and E. coli and its promotion of liver parenchymal cell infiltration, vascularization, and tissue integration in a rat liver defect model. Overall, the MACS demonstrates promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.

scholarly journals A novel microcurrent dressing for wound healing in a rat skin defect model

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Chao Yu ◽  
Zhi-Xiu Xu ◽  
Yan-Hui Hao ◽  
Ya-Bing Gao ◽  
Bin-Wei Yao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Defect ◽  
Rat Skin ◽  
Defect Model ◽  
Microcurrent Dressing

scholarly journals A Novel Multilayer Composite Membrane for Wound Healing in Mice Skin Defect Model

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 573 ◽  
Author(s):  
Yuyu Qiu ◽  
Qingqing Wang ◽  
Yajun Chen ◽  
Shufang Xia ◽  
Wei Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Process ◽  
Animal Experiments ◽  
Skin Wound ◽  
Control Group ◽  
Skin Defect ◽  
Multilayer Composite ◽  
Defect Model ◽  
Skin Wound Healing

To develop a wound dressing material that conforms to the healing process, we prepared a multilayer composite (MC) membrane consisting of an antibacterial layer (ABL), a reinforcement layer (RFL), and a healing promotion layer (HPL). Biocompatible zein/ethyl cellulose (zein/EC) electrospun nanofibrous membranes with in situ loaded antibacterial photosensitizer protoporphyrin (PPIX) and healing promotion material vaccarin (Vac) were, respectively, chosen as the ABL on the surface and the HPL on the bottom, between which nonwoven incorporated bacterial cellulose (BC/PETN) as the HPL was intercalated to enhance the mechanical property. Photodynamic antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was confirmed by the enlarged inhibition zones; meanwhile, satisfactory biocompatibility of the HPL was verified by scanning electronic microscopy (SEM) of L929 cells cultured on its surface. The potential effects on wound healing in a mice skin defect model of the MC membranes were also evaluated. The animal experiments demonstrated that the wound healing rate in the MC group was significantly increased compared with that in the control group (p < 0.05). Histopathological observation revealed an alleviated inflammatory response, accompanied with vascular proliferation in the MC group. The MC membranes significantly promoted wound healing by creating an antibacterial environment and promoting angiogenesis. Taken together, this MC membrane may act as a promising wound dressing for skin wound healing.

scholarly journals Comparison of the wound healing efficacy of polyglycolic acid sheets with fibrin glue and gelatin sponge dressings in a rat cranial periosteal defect model

2016 ◽  
Vol 65 (4) ◽  
pp. 473-483 ◽  
Author(s):  
Shinya Koshinuma ◽  
Shoko Murakami ◽  
Masaharu Noi ◽  
Takuya Murakami ◽  
Ken-Ichi Mukaisho ◽  
...  
Keyword(s):  
Wound Healing ◽  
Fibrin Glue ◽  
Polyglycolic Acid ◽  
Gelatin Sponge ◽  
Defect Model

Hyaluronic acid/lysozyme self-assembled coacervate to promote cutaneous wound healing

2020 ◽  
Vol 8 (6) ◽  
pp. 1702-1710 ◽  
Author(s):  
Xiaoye Zhao ◽  
Lin Wang ◽  
Jushan Gao ◽  
Xi Chen ◽  
Ke Wang
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Skin Defect ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Defect Model ◽  
Cutaneous Wound ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Self Assembled

The preparation and wound healing in a full-thickness skin defect model of HL coacervate.

scholarly journals Macrophage Control of Incipient Bone Formation in Diabetic Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Miya Kang ◽  
Ghadeer Thalji ◽  
Chun-Chieh Huang ◽  
Sajjad Shirazi ◽  
Yu Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bone Regeneration ◽  
Mouse Strains ◽  
Hard Tissue ◽  
Defect Model ◽  
Endosseous Implants ◽  
Immunological Responses ◽  
Mouse Calvaria ◽  
Healing Bone

Both soft and hard tissue wound healing are impaired in diabetes. Diabetes negatively impacts fracture healing, bone regeneration and osseointegration of endosseous implants. The complex physiological changes associated with diabetes often manifest in immunological responses to wounding and repair where macrophages play a prominent role in determining outcomes. We hypothesized that macrophages in diabetes contribute toward impaired osseous wound healing. To test this hypothesis, we compared osseous wound healing in the mouse calvaria defect model using macrophages from C57BL/6J and db/db mice to direct osseous repair in both mouse strains. Initial analyses revealed that db/db mice macrophages showed an inflamed phenotype in its resting state. Incipient bone regeneration evaluated by μCT indicated that bone regeneration was relatively impaired in the db/db mouse calvaria and in the calvaria of C57BL/6J mice supplemented with db/db macrophages. Furthermore, osteogenic differentiation of mouse mesenchymal stem cells was negatively impacted by conditioned medium from db/db mice compared to C57BL/6J mice. Moreover, miR-Seq analysis revealed an altered miRNA composition in db/db macrophages with up regulated pro-inflammatory miRNAs and down regulated anti-inflammatory miRNAs. Overall, this study represents a direct step toward understanding macrophage-mediated regulation of osseous bone regeneration and its impairment in type 2 diabetes mellitus.

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