Noncontact Viscoelastic Imaging of Living Cells Using a Long-Needle Atomic Force Microscope with Dual-Frequency Modulation

2017 ◽  
Vol 8 (4) ◽  
Author(s):  
Dongshi Guan ◽  
Elisabeth Charlaix ◽  
Robert Z. Qi ◽  
Penger Tong
Keyword(s):  
Atomic Force Microscope ◽  
Frequency Modulation ◽  
Living Cells ◽  
Dual Frequency ◽  
Atomic Force

Computational Development of Single- and Dual-Frequency Modulation Atomic Force Spectroscopy for Ambient Air Applications

2009 ◽  
Author(s):  
Gaurav Chawla ◽  
Santiago D. Solares
Keyword(s):  
Frequency Modulation ◽  
Force Spectroscopy ◽  
Ambient Air ◽  
Interaction Force ◽  
Single Frequency ◽  
Dual Frequency ◽  
Rapid Acquisition ◽  
Atomic Force ◽  
Modulation Mode ◽  
Force Curves

The ability of atomic force microscopy (AFM) to acquire tip-sample interaction force curves has allowed researchers to understand the mechanical behavior of numerous materials at the nanoscale. However, AFM force spectroscopy with the most commonly used techniques can be a slow process for non-uniform samples, as it often requires the measurement to be performed at one fixed surface point at a time. In this paper we present two dynamic AFM based spectroscopy methods, one requiring operation in single-frequency-modulation mode and another using dual-frequency-modulation, which could allow a more rapid acquisition of topography and tip-sample interaction force curves. Numerical simulation results are provided along with discussions on the benefits and limitations of both.

Image Calculations with a Numerical Frequency-Modulation Atomic Force Microscope

2013 ◽  
Vol 117 (20) ◽  
pp. 10492-10501 ◽  
Author(s):  
F. Castanié ◽  
L. Nony ◽  
S. Gauthier ◽  
X. Bouju
Keyword(s):  
Atomic Force Microscope ◽  
Frequency Modulation ◽  
Atomic Force

scholarly journals Adhesion forces measured between a calcium blocker drug and its receptor in living cells using atomic force microscope

FEBS Letters ◽  
2003 ◽  
Vol 552 (2-3) ◽  
pp. 155-159 ◽  
Author(s):  
Ricardo de Souza Pereira ◽  
Maria Ivonete Nogueira da Silva ◽  
Mônica Alonso Cotta
Keyword(s):  
Atomic Force Microscope ◽  
Living Cells ◽  
Adhesion Forces ◽  
Atomic Force ◽  
Calcium Blocker

High-speed force mapping on living cells with a small cantilever atomic force microscope

2014 ◽  
Vol 85 (7) ◽  
pp. 073703 ◽  
Author(s):  
Christoph Braunsmann ◽  
Jan Seifert ◽  
Johannes Rheinlaender ◽  
Tilman E. Schäffer
Keyword(s):  
Atomic Force Microscope ◽  
High Speed ◽  
Living Cells ◽  
Atomic Force ◽  
Force Mapping
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