G-Protein Modulation of Voltage-Gated Ca2+Channels from Isolated Adult Rat Superior Cervical Ganglion Neurons

2016 ◽  
Vol 2016 (5) ◽  
pp. pdb.prot091223
Author(s):  
Van B. Lu ◽  
Stephen R. Ikeda
Keyword(s):  
G Protein ◽  
Superior Cervical Ganglion ◽  
Voltage Gated ◽  
Adult Rat ◽  
Cervical Ganglion ◽  
Ganglion Neurons ◽  
Ca2 Channels

Ethanol inhibits voltage-gated sodium channels in cultured superior cervical ganglion neurons

Neuroreport ◽  
2008 ◽  
Vol 19 (18) ◽  
pp. 1773-1776 ◽  
Author(s):  
Zheman Xiao ◽  
Zuneng Lu ◽  
Zhongchun Liu ◽  
Wanhong Liu ◽  
Lijun Li ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Superior Cervical Ganglion ◽  
Voltage Gated ◽  
Voltage Gated Sodium Channels ◽  
Cervical Ganglion ◽  
Ganglion Neurons

Pancreatic polypeptide inhibits calcium channels in rat sympathetic neurons via two signaling pathways

1995 ◽  
Vol 73 (3) ◽  
pp. 1323-1328 ◽  
Author(s):  
L. P. Wollmuth ◽  
M. S. Shapiro ◽  
B. Hille
Keyword(s):  
G Protein ◽  
Pertussis Toxin ◽  
Pancreatic Polypeptide ◽  
Sympathetic Neurons ◽  
Whole Cell ◽  
Adult Rat ◽  
Voltage Dependent ◽  
Cervical Ganglion ◽  
Gamma S ◽  
Ca2 Channels

1. We studied modulation of N-type Ca2+ channels in adult rat superior cervical ganglion (SCG) neurons by pancreatic polypeptide (PP) using whole cell clamp. In large (> 20 pF) SCG neurons, PP inhibited ICa (35 +/- 2%, mean +/- SE) in a concentration-dependent fashion, with one-half maximal inhibition at 19 nM. 2. One-third of the inhibition was blocked by pertussis toxin, about one-half was blocked by N-ethylmaleimide (NEM) treatments, and about one-half was voltage dependent. The NEM-insensitive component of the PP inhibition was voltage independent and not significantly blocked by intracellular Ca2+ chelators. 3. The NEM-insensitive component was only weakly attenuated by GDP-beta-S, and moderately reversible with guanosine 5'-triphosphate (GTP)-gamma-S, in the whole cell pipette, leaving open the possibility that it is not mediated by a G protein. 4. Hence, PP inhibits ICa via two mechanisms: one G-protein-mediated and the other possibly G-protein independent. The former pathway is sensitive to pertussis toxin (PTX) and NEM, voltage dependent, and shared by several other transmitters in these cells. The latter pathway is PTX-and NEM-insensitive, not voltage dependent, and not affected by the presence of intracellular Ca2+ chelators.

scholarly journals Modulation of Voltage-Gated Ca2+ Channels by G Protein-Coupled Receptors in Celiac-Mesenteric Ganglion Neurons of Septic Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125566 ◽  
Author(s):  
Mohamed Farrag ◽  
Lacee J. Laufenberg ◽  
Jennifer L. Steiner ◽  
Gregory E. Weller ◽  
Charles H. Lang ◽  
...  
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptors ◽  
Voltage Gated ◽  
Mesenteric Ganglion ◽  
Ganglion Neurons ◽  
G Protein Coupled ◽  
Ca2 Channels

Somatostatin blocks a calcium current in acutely isolated adult rat superior cervical ganglion neurons

1987 ◽  
Vol 81 (1-2) ◽  
pp. 123-128 ◽  
Author(s):  
Stephen R. Ikeda ◽  
Geoffrey G. Schofield ◽  
Forrest F. Weight
Keyword(s):  
Superior Cervical Ganglion ◽  
Calcium Current ◽  
Adult Rat ◽  
Cervical Ganglion ◽  
Ganglion Neurons

scholarly journals Activity of Palythoa caribaeorum Venom on Voltage-Gated Ion Channels in Mammalian Superior Cervical Ganglion Neurons

Toxins ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 135 ◽  
Author(s):  
Fernando Lazcano-Pérez ◽  
Héctor Castro ◽  
Isabel Arenas ◽  
David García ◽  
Ricardo González-Muñoz ◽  
...  
Keyword(s):  
Ion Channels ◽  
Superior Cervical Ganglion ◽  
Voltage Gated ◽  
Palythoa Caribaeorum ◽  
Cervical Ganglion ◽  
Voltage Gated Ion Channels ◽  
Ganglion Neurons ◽  
Gated Ion Channels
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