scholarly journals Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways

2009 ◽  
Vol 23 (6) ◽  
pp. 681-693 ◽  
Author(s):  
S. Ghisletti ◽  
W. Huang ◽  
K. Jepsen ◽  
C. Benner ◽  
G. Hardiman ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Inflammatory Signaling ◽  
Anti Inflammatory

scholarly journals Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Raquibul Hasan ◽  
Shoumen Lasker ◽  
Ahasanul Hasan ◽  
Farzana Zerin ◽  
Mushfera Zamila ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Inflammatory Signaling ◽  
Anti Inflammatory

scholarly journals Lysophosphatidic Acid Inhibits Bacterial Endotoxin-Induced Pro-Inflammatory Response: Potential Anti-Inflammatory Signaling Pathways

2008 ◽  
Vol 14 (7-8) ◽  
pp. 422-428 ◽  
Author(s):  
Hongkuan Fan ◽  
Basilia Zingarelli ◽  
Vashaunta Harris ◽  
George E. Tempel ◽  
Perry V. Halushka ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Signaling Pathways ◽  
Lysophosphatidic Acid ◽  
Bacterial Endotoxin ◽  
Inflammatory Signaling ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Effects of Ellagic Acid on Keratinocytes via MAPK and STAT Pathways

2021 ◽  
Vol 22 (3) ◽  
pp. 1277
Author(s):  
Tae-Young Gil ◽  
Chul-Hee Hong ◽  
Hyo-Jin An
Keyword(s):  
Signaling Pathways ◽  
Ellagic Acid ◽  
Inflammatory Responses ◽  
Skin Barrier ◽  
Skin Lesions ◽  
In Vivo Studies ◽  
Inflammatory Signaling ◽  
Inflammatory Reactions ◽  
Anti Inflammatory

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by an impaired skin barrier and intense itchiness, which decreases the individual’s quality of life. No fully effective therapeutic agents have prevailed for AD due to an insufficient grasp of the complex etiology. Ellagic acid (EA), a natural compound, has anti-inflammatory properties in chronic diseases. The effects of EA on AD have not yet been explored. The present study investigated the effects of EA on TNF-α/IFN-γ-stimulated HaCaT keratinocytes and house dust mite-induced AD-like skin lesions in NC/Nga mice. Treatment with EA suppressed inflammatory responses in keratinocytes by regulating critical inflammatory signaling pathways, such as mitogen-activated protein kinases and signal transducers and activators of transcription. In vivo studies using a DfE-induced AD mouse model showed the effects of EA administration through ameliorated skin lesions via decremented histological inflammatory reactions. These results suggest that EA could be a potential therapeutic alternative for the treatment of AD by inhibiting inflammatory signaling pathways.

scholarly journals Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages

2014 ◽  
Vol 194 (2) ◽  
pp. 584-594 ◽  
Author(s):  
Yanfang Peipei Zhu ◽  
Jonathan R. Brown ◽  
Duygu Sag ◽  
Lihua Zhang ◽  
Jill Suttles
Keyword(s):  
Protein Kinase ◽  
Signaling Pathways ◽  
Inflammatory Signaling ◽  
Anti Inflammatory

scholarly journals Copper/zinc-loaded montmorillonite influences intestinal integrity, the expression of genes associated with inflammation, TLR4–MyD88 and TGF-β1 signaling pathways in weaned pigs after LPS challenge

2017 ◽  
Vol 23 (8) ◽  
pp. 648-655 ◽  
Author(s):  
Lefei Jiao ◽  
Chun Chun Wang ◽  
Huan Wu ◽  
Rong Gong ◽  
Fang Hui Lin ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Intestinal Inflammation ◽  
Intestinal Injury ◽  
Control Group ◽  
Mrna Levels ◽  
Inflammatory Signaling ◽  
Copper Zinc ◽  
Anti Inflammatory ◽  
Tgf Β1

This study was aimed at investigating whether dietary copper/zinc-loaded montmorillonite (Cu/Zn-Mt) could alleviate Escherichia coli LPS-induced intestinal injury through pro- and anti-inflammatory signaling pathways (TLRs, NLRs and TGF-β1) in weaned piglets. Eighteen 21-d-old pigs were randomly divided into three groups (control, LPS and LPS + Cu/Zn-Mt). After 21 d of feeding, pigs in the LPS group and LPS + Cu/Zn-Mt group received i.p. administration of LPS, whereas pigs in the control group received saline. At 4 h post-injection, jejunum samples were collected for analysis. The results indicated that, compared with the LPS group, supplemental Cu/Zn-Mt increased transepithelial electrical resistance, the expressions of anti-inflammatory cytokines (TGF-β1) in mRNA and protein levels, and decreased FD4 and the mRNA expression of pro-inflammatory cytokines (TNF-α, IL-6, IL-8 and IL-1β). The pro-inflammatory signaling pathways results demonstrated that Cu/Zn-Mt supplementation decreased the mRNA levels of TLR4 and its downstream signals (MyD88, IRAK1, TRAF6) but had no effect on NOD1 and NOD2 signals. Cu/Zn-Mt supplementation did not affect NF-κB p65 mRNA abundance, but down-regulated its protein expression. The anti-inflammatory signaling pathways results showed supplemental Cu/Zn-Mt also increased TβRII, Smad4 and Smad7 mRNA expressions. These findings suggested dietary Cu/Zn-Mt attenuated LPS-induced intestinal injury by alleviating intestinal inflammation, influencing TLR4-MyD88 and TGF-β1 signaling pathways in weaned pig.

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