scholarly journals A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization

2004 ◽  
Vol 18 (12) ◽  
pp. 1452-1465 ◽  
Author(s):  
W. Gu
Keyword(s):  
Mrna Translation ◽  
Family Protein ◽  
New Yeast ◽  
Ash1 Mrna ◽  
Puf Family

scholarly journals The target specificity of the RNA binding protein Pumilio is determined by distinct co-factors

2019 ◽  
Vol 39 (6) ◽  
Author(s):  
Sumira Malik ◽  
Wijeong Jang ◽  
Song Yeon Park ◽  
Ji Young Kim ◽  
Ki-Sun Kwon ◽  
...  
Keyword(s):  
Cell Fate ◽  
Rna Binding ◽  
Neural Function ◽  
Target Specificity ◽  
Family Protein ◽  
Wide Range ◽  
Bag Of Marbles ◽  
Translational Regulators ◽  
Underlying Mechanisms ◽  
Puf Family

Abstract Puf family proteins are translational regulators essential to a wide range of biological processes, including cell fate specification, stem cell self-renewal, and neural function. Yet, despite being associated with hundreds of RNAs, the underlying mechanisms of Puf target specification remain to be fully elucidated. In Drosophila, Pumilio – a sole Puf family protein – is known to collaborate with cofactors Nanos (Nos) and Brain Tumor (Brat); however, their roles in target specification are not clearly defined. Here, we identify Bag-of-marbles (Bam) as a new Pum cofactor in repression of Mothers against dpp (mad) mRNAs, for which Nos is known to be dispensable. Notably, our data show that Nos (but not Bam) was required for Pum association with hunchback (hb) mRNAs, a well-known target of Pum and Nos. In contrast, Bam (but not Nos) was required for Pum association with mad mRNAs. These findings show for the first time that Pum target specificity is determined not independently but in collaboration with cofactors.

scholarly journals Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein

Cell Research ◽  
2012 ◽  
Vol 23 (3) ◽  
pp. 320-322 ◽  
Author(s):  
Martin R Jakobsen ◽  
Trine H Mogensen ◽  
Søren R Paludan
Keyword(s):  
Mrna Translation ◽  
Family Protein

scholarly journals APUM23, a PUF family protein, functions in leaf development and organ polarity in Arabidopsis

2014 ◽  
Vol 65 (4) ◽  
pp. 1181-1191 ◽  
Author(s):  
Tengbo Huang ◽  
Randall A. Kerstetter ◽  
Vivian F. Irish
Keyword(s):  
Leaf Development ◽  
Family Protein ◽  
Protein Functions ◽  
Puf Family

scholarly journals Local Activation of Yeast ASH1 mRNA Translation through Phosphorylation of Khd1p by the Casein Kinase Yck1p

2007 ◽  
Vol 26 (6) ◽  
pp. 795-809 ◽  
Author(s):  
Nicolas Paquin ◽  
Marie Ménade ◽  
Guillaume Poirier ◽  
Damiane Donato ◽  
Emmanuel Drouet ◽  
...  
Keyword(s):  
Mrna Translation ◽  
Casein Kinase ◽  
Local Activation ◽  
Ash1 Mrna

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)

2019 ◽  
Author(s):  
James Papatzimas ◽  
Evgueni Gorobets ◽  
Ranjan Maity ◽  
Mir Ishruna Muniyat ◽  
Justin L. MacCallum ◽  
...  
Keyword(s):  
Small Molecules ◽  
E3 Ligase ◽  
Myeloid Cell ◽  
Cell Leukemia ◽  
New Class ◽  
Apoptotic Protein ◽  
Family Protein ◽  
Ubiquitination Pathway

<div> <div> <div> <p>Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family protein degraders. </p> </div> </div> </div>

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