Lung Regeneration: Cells, Models, and Mechanisms

2021 ◽  
pp. a040873
Author(s):  
Arvind Konkimalla ◽  
Aleksandra Tata ◽  
Purushothama Rao Tata
Keyword(s):  
Lung Regeneration

scholarly journals Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration

2008 ◽  
Vol 294 (6) ◽  
pp. L1158-L1165 ◽  
Author(s):  
R. D. Nolen-Walston ◽  
C. F. Kim ◽  
M. R. Mazan ◽  
E. P. Ingenito ◽  
A. M. Gruntman ◽  
...  
Keyword(s):  
Alveolar Epithelial Cells ◽  
Substantial Contribution ◽  
Potential Contribution ◽  
Type I ◽  
Alveolar Epithelial ◽  
Cellular Kinetics ◽  
Organ Regeneration ◽  
Alveolar Tissue ◽  
Cell Densities ◽  
Lung Regeneration

Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown. Whereas postnatal regeneration of alveolar tissue has been attributed to type II alveolar epithelial cells (AECII), we reasoned that bronchioalveolar stem cells (BASCs) have the potential to contribute substantially to this process. To test this hypothesis, unilateral pneumonectomy (PNX) was performed on adult female C57/BL6 mice to stimulate compensatory lung regrowth. The density of BASCs and AECII, and morphometric and physiological measurements, were recorded on days 1, 3, 7, 14, 28, and 45 after surgery. Vital capacity was restored by day 7 after PNX. BASC numbers increased by day 3, peaked to 220% of controls ( P < 0.05) by day 14, and then returned to baseline after active lung regrowth was complete, whereas AECII cell densities increased to 124% of baseline (N/S). Proliferation studies revealed significant BrdU uptake in BASCs and AECII within the first 7 days after PNX. Quantitative analysis using a systems biology model was used to evaluate the potential contribution of BASCs and AECII. The model demonstrated that BASC proliferation and differentiation contributes between 0 and 25% of compensatory alveolar epithelial (type I and II cell) regrowth, demonstrating that regeneration requires a substantial contribution from AECII. The observed cell kinetic profiles can be reconciled using a dual-compartment (BASC and AECII) proliferation model assuming a linear hierarchy of BASCs, AECII, and AECI cells to achieve lung regrowth.

Endogenous Lung Regeneration

2012 ◽  
Vol 186 (12) ◽  
pp. 1213-1219 ◽  
Author(s):  
Jason Rock ◽  
Melanie Königshoff
Keyword(s):  
Lung Regeneration

Distal Airway Stem Cells are Essential for Lung Regeneration

2015 ◽  
Vol 99 (8) ◽  
pp. 1540-1541 ◽  
Author(s):  
Tobias Deuse ◽  
Sonja Schrepfer
Keyword(s):  
Stem Cells ◽  
Distal Airway ◽  
Lung Regeneration

scholarly journals FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Craig Bolte ◽  
Hannah M. Flood ◽  
Xiaomeng Ren ◽  
Sajjeev Jagannathan ◽  
Artem Barski ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Regeneration

scholarly journals Roles of Mesenchymal Cells in the Lung: From Lung Development to Chronic Obstructive Pulmonary Disease

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3467
Author(s):  
Amel Nasri ◽  
Florent Foisset ◽  
Engi Ahmed ◽  
Zakaria Lahmar ◽  
Isabelle Vachier ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Lung Development ◽  
Lung Diseases ◽  
Mesenchymal Cells ◽  
Chronic Obstructive ◽  
Multilineage Differentiation ◽  
Cell Type ◽  
Obstructive Pulmonary Disease ◽  
Lung Regeneration

Mesenchymal cells are an essential cell type because of their role in tissue support, their multilineage differentiation capacities and their potential clinical applications. They play a crucial role during lung development by interacting with airway epithelium, and also during lung regeneration and remodeling after injury. However, much less is known about their function in lung disease. In this review, we discuss the origins of mesenchymal cells during lung development, their crosstalk with the epithelium, and their role in lung diseases, particularly in chronic obstructive pulmonary disease.

LUNG REGENERATION IN ABSTAINING SMOKERS

2019 ◽  
Vol 186 (2-3) ◽  
pp. 397-400
Author(s):  
Radoslav Böhm ◽  
Antonín Sedlák ◽  
Martin Bulko ◽  
Karol Holý
Keyword(s):  
Chronic Bronchitis ◽  
Biological Effects ◽  
Physiological Parameters ◽  
Lung Damage ◽  
Regeneration Process ◽  
Risk Of Infection ◽  
Decay Products ◽  
Long Time ◽  
Self Cleaning ◽  
Lung Regeneration

Abstract Smoking modifies morphological and physiological parameters of the lungs. Due to the irritation of airways, the natural self-cleaning ability of the lungs is impaired. The mucus accumulates in the airways and various infections develop, leading to chronic bronchitis. After the cessation of smoking, the lungs of the smoker start to heal and regenerate. Cilia in the lungs start to grow again and cleanse the lungs, thus reducing the risk of infection. The regeneration of the lungs takes a long time and depends on the degree of lung damage due to smoking. The aim of this study was to reconstruct the evolution of this regeneration process in chronic smokers by using the biological effects of radon and its decay products. Thus, radon in this study served as a tracer of changes induced by smoking.

scholarly journals The role of retinoic acid in embryonic and post-embryonic development

2000 ◽  
Vol 59 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Malcolm Maden
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
Embryonic Development ◽  
Cell Regeneration ◽  
Spinal Cord Regeneration ◽  
Experimental Paradigm ◽  
Hair Cell Regeneration ◽  
X Receptors ◽  
Lung Regeneration

Retinoic acid (RA) is the bioactive metabolite of vitamin A (retinol) which acts on cells to establish or change the pattern of gene activity. Retinol is converted to RA by the action of two types of enzyme, retinol dehydrogenases and retinal dehydrogenases. In the nucleus RA acts as a ligand to activate two families of transcription factors, the RA receptors (RAR) and the retinoid X receptors (RXR) which heterodimerize and bind to the upstream sequences of RA-responsive genes. Thus, in addition to the well-established experimental paradigm of depriving animals of vitamin A to determine the role of RA in embryonic and post-embryonic development, molecular biology has provided us with two additional methodologies: knockout the enzymes or the RAR and RXR in the mouse embryo. The distribution of the enzymes and receptors, and recent experiments to determine the endogenous distribution of RA in the embryo are described here, as well as the effects on the embryo of knocking out the enzymes and receptors. In addition, recent studies using the classical vitamin A-deprivation technique are described, as they have provided novel insights into the regions of the embryo which crucially require RA, and the gene pathways involved in their development. Finally, the post-embryonic or regenerating systems in which RA plays a part are described, i.e. the regenerating limb, lung regeneration, hair cell regeneration in the ear and spinal cord regeneration in the adult.

Lung regeneration and translational implications of the postpneumonectomy model

2014 ◽  
Vol 163 (4) ◽  
pp. 363-376 ◽  
Author(s):  
Kristen Thane ◽  
Edward P. Ingenito ◽  
Andrew M. Hoffman
Keyword(s):  
Lung Regeneration

scholarly journals Imaging lung regeneration by light sheet microscopy

2020 ◽  
Author(s):  
Isabelle Salwig ◽  
Birgit Spitznagel ◽  
Marion Wiesnet ◽  
Thomas Braun
Keyword(s):  
Light Sheet ◽  
Light Sheet Microscopy ◽  
Lung Regeneration
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