scholarly journals Efferent Inhibition of the Cochlea

2018 ◽  
Vol 9 (5) ◽  
pp. a033530 ◽  
Author(s):  
Paul Albert Fuchs ◽  
Amanda M. Lauer
Keyword(s):  
Efferent Inhibition

Efferent inhibition of carotid body chemoreception in chronically hypoxic cats

1983 ◽  
Vol 245 (5) ◽  
pp. R678-R683 ◽  
Author(s):  
S. Lahiri ◽  
N. Smatresk ◽  
M. Pokorski ◽  
P. Barnard ◽  
A. Mokashi
Keyword(s):  
Sea Level ◽  
Chronic Exposure ◽  
Chronic Hypoxia ◽  
Carotid Sinus ◽  
Afferent Activity ◽  
Efferent Inhibition ◽  
Before And After ◽  
Steady State Responses ◽  
Chemosensory Response ◽  
State Responses

The effects of chronic hypoxia on carotid chemoreceptor afferent activity before and after sectioning the carotid sinus nerves (CSN) were studied in cats exposed to 10% O2 for 21–49 days in a chamber at sea level. For comparison, chronically normoxic cats at sea level were also studied. The cats were anesthetized, paucifiber preparation for the measurement of carotid chemosensory activity from a small slip of CSN was made, and their steady-state responses to 4–5 levels of arterial pressure of O2 (PaO2) at a constant PaCO2 and to 3–4 levels of PaCO2 in hyperoxia were measured before and after sectioning the CSN. The chemosensory response to hypoxia in the cats with intact CSN after chronic exposure to hypoxia was not reduced relative to the cats that breathed room air at sea level. Sectioning the CSN significantly augmented the chemosensory responses to hypoxia in all the chronically hypoxic but not significantly in the normoxic cats. The responses to moderate hypercapnia during hyperoxia were not significantly changed by cutting the CSN in either group. We conclude that there is a significant CSN efferent inhibition of chemosensory activity due to chronic hypoxia in the cat. This implies that without the efferent inhibition the hypoxic chemosensitivity is increased by chronic hypoxia.

Dopaminergic efferent inhibition of carotid body chemoreceptors in chronically hypoxic cats

1984 ◽  
Vol 247 (1) ◽  
pp. R24-R28 ◽  
Author(s):  
S. Lahiri ◽  
N. Smatresk ◽  
M. Pokorski ◽  
P. Barnard ◽  
A. Mokashi ◽  
...  
Keyword(s):  
Dopamine Receptor ◽  
Carotid Body ◽  
Carotid Sinus ◽  
Dopamine Antagonist ◽  
Receptor Blockade ◽  
Endogenous Dopamine ◽  
Efferent Inhibition ◽  
O2 Partial Pressure ◽  
Haloperidol Treatment ◽  
Carotid Body Chemoreceptors

The observations that the dopamine concentration of the carotid body and efferent inhibition of carotid chemoreceptors are increased during chronic hypoxia led to the hypothesis that the inhibition was due to the effect of an increased dopamine release by the activity of carotid sinus nerve (CSN) efferents. The hypothesis was tested by measuring the effect of dopamine receptor blockade on efferent inhibition of carotid chemosensory responses to graded levels of arterial O2 partial pressure in chronically hypoxic and normoxic cats. Chronically hypoxic cats were prepared by exposing the cats to 10% O2 at sea level for 30–34 days. Carotid chemosensory activity was first measured from a slip of an otherwise intact CSN. The measurements were then repeated after sectioning the remaining nerve trunk. The effect of sectioning the CSN provided the measure of efferent inhibition. In each group of cats the effects of sectioning the CSN with and without dopamine receptor blockade by haloperidol were also studied. CSN section augmented the chemosensory responses in the chronically hypoxic cats. Haloperidol, a dopamine antagonist, augmented the responses further, indicating that a part of the endogenous dopamine effect was independent of the CSN efferents. After haloperidol treatment CSN section did not influence the chemosensory responses. This study confirmed that the efferent inhibition significantly increased in the chronically hypoxic cats and demonstrated that haloperidol blocked the efferent inhibition, suggesting that the mechanism of the augmented inhibition is dopaminergic.

scholarly journals mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea

2017 ◽  
Vol 595 (11) ◽  
pp. 3483-3495 ◽  
Author(s):  
Zhanlei Ye ◽  
Juan D. Goutman ◽  
Sonja J. Pyott ◽  
Elisabeth Glowatzki
Keyword(s):  
Hair Cells ◽  
Inner Hair Cells ◽  
Efferent Inhibition ◽  
Rat Cochlea ◽  
Developing Rat

Fast cholinergic efferent inhibition in guinea pig outer hair cells

2006 ◽  
Vol 1102 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Wei-Jia Kong ◽  
Chang-Kai Guo ◽  
Song Zhang ◽  
Xiao-Wen Zhang ◽  
Yan-jun Wang ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Hair Cells ◽  
Outer Hair Cells ◽  
Efferent Inhibition
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