scholarly journals mGluR1 enhances efferent inhibition of inner hair cells in the developing rat cochlea

2017 ◽  
Vol 595 (11) ◽  
pp. 3483-3495 ◽  
Author(s):  
Zhanlei Ye ◽  
Juan D. Goutman ◽  
Sonja J. Pyott ◽  
Elisabeth Glowatzki
Keyword(s):  
Hair Cells ◽  
Inner Hair Cells ◽  
Efferent Inhibition ◽  
Rat Cochlea ◽  
Developing Rat

scholarly journals Facilitating efferent inhibition of inner hair cells in the cochlea of the neonatal rat

2005 ◽  
Vol 566 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Juan Diego Goutman ◽  
Paul Albert Fuchs ◽  
Elisabeth Glowatzki
Keyword(s):  
Hair Cells ◽  
Neonatal Rat ◽  
Inner Hair Cells ◽  
Efferent Inhibition

scholarly journals Voltage-Gated Calcium Influx Modifies Cholinergic Inhibition of Inner Hair Cells in the Immature Rat Cochlea

2018 ◽  
Vol 38 (25) ◽  
pp. 5677-5687 ◽  
Author(s):  
Stephen Zachary ◽  
Nathaniel Nowak ◽  
Pankhuri Vyas ◽  
Luke Bonanni ◽  
Paul Albert Fuchs
Keyword(s):  
Hair Cells ◽  
Calcium Influx ◽  
Immature Rat ◽  
Inner Hair Cells ◽  
Voltage Gated ◽  
Rat Cochlea

scholarly journals Inner hair cell stereocilia are embedded in the tectorial membrane

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Pierre Hakizimana ◽  
Anders Fridberger
Keyword(s):  
Electron Microscopy ◽  
Hair Cell ◽  
Mechanical Stimulation ◽  
Hair Cells ◽  
Viscous Drag ◽  
Tectorial Membrane ◽  
Inner Hair Cell ◽  
Inner Hair Cells ◽  
Inward Currents

AbstractMammalian hearing depends on sound-evoked displacements of the stereocilia of inner hair cells (IHCs), which cause the endogenous mechanoelectrical transducer channels to conduct inward currents of cations including Ca2+. Due to their presumed lack of contacts with the overlaying tectorial membrane (TM), the putative stimulation mechanism for these stereocilia is by means of the viscous drag of the surrounding endolymph. However, despite numerous efforts to characterize the TM by electron microscopy and other techniques, the exact IHC stereocilia-TM relationship remains elusive. Here we show that Ca2+-rich filamentous structures, that we call Ca2+ ducts, connect the TM to the IHC stereocilia to enable mechanical stimulation by the TM while also ensuring the stereocilia access to TM Ca2+. Our results call for a reassessment of the stimulation mechanism for the IHC stereocilia and the TM role in hearing.

The efferents interconnecting auditory inner hair cells

1994 ◽  
Vol 75 (1-2) ◽  
pp. 81-92 ◽  
Author(s):  
H.M. Sobkowicz ◽  
S.M. Slapnick
Keyword(s):  
Hair Cells ◽  
Inner Hair Cells

Calcium- and Calmodulin-Dependent Inactivation of Calcium Channels in Inner Hair Cells of the Rat Cochlea

2008 ◽  
Vol 99 (5) ◽  
pp. 2183-2193 ◽  
Author(s):  
Lisa Grant ◽  
Paul Fuchs
Keyword(s):  
Calcium Channels ◽  
Hair Cells ◽  
Calcium Currents ◽  
Resting Potential ◽  
Resting Membrane Potential ◽  
Inner Hair Cells ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Dependent Inactivation ◽  
Calcium Buffering

Modulation of voltage-gated calcium channels was studied in inner hair cells (IHCs) in an ex vivo preparation of the apical turn of the rat organ of Corti. Whole cell voltage clamp in the presence of potassium channel blockers showed inward calcium currents with millisecond activation and deactivation kinetics. When temperature was raised from 22 to 37°C, the calcium currents of immature IHCs [<12 days postnatal (P12)] increased threefold in amplitude, and developed more pronounced inactivation. This was determined to be calcium-dependent inactivation (CDI) on the basis of its reliance on external calcium (substitution with barium), sensitivity to internal calcium-buffering, and voltage dependence (reflecting the calcium driving force). After the onset of hearing at P12, IHC calcium current amplitude and the extent of inactivation were greatly reduced. Although smaller than in prehearing IHCs, CDI remained significant in the mature IHC near the resting membrane potential. CDI in mature IHCs was enhanced by application of the endoplasmic calcium pump blocker, benzo-hydroquinone. Conversely, CDI in immature IHCs was reduced by calmodulin inhibitors. Thus voltage-gated calcium channels in mammalian IHCs are subject to a calmodulin-mediated process of CDI. The extent of CDI depends on the balance of calcium buffering mechanisms and may be regulated by calmodulin-specific processes. CDI provides a means for the rate of spontaneous transmitter release to be adjusted to variations in hair cell resting potential and steady state calcium influx.

scholarly journals Author Correction: Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1

Nature ◽  
2018 ◽  
Vol 565 (7737) ◽  
pp. E2-E2
Author(s):  
Teerawat Wiwatpanit ◽  
Sarah M. Lorenzen ◽  
Jorge A. Cantú ◽  
Chuan Zhi Foo ◽  
Ann K. Hogan ◽  
...  
Keyword(s):  
Hair Cells ◽  
Outer Hair Cells ◽  
Inner Hair Cells
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