scholarly journals Porous upconversion nanostructures as bimodal biomedical imaging contrast agents

2019 ◽  
Author(s):  
Ziqing Du ◽  
Abhishek Gupta ◽  
Christian Clarke ◽  
Matt Cappadana ◽  
David Clases ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Imaging Techniques ◽  
Fluorescent Imaging ◽  
Lanthanide Ions ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Porous Shell ◽  
The Core ◽  
Surface Areas

AbstractLanthanide ions doped upconversion nanoparticles (UCNPs) hold great promise as the imaging contrast agent for multimodal medical imaging techniques for diagnosis, including fluorescent bioimaging, magnetic resonance imaging, and computed tomography. However, the maximized signal values of fluorescence and MRI cannot be achieved simultaneously from the same upconversion nanoparticles structures because high specific surface areas can benefit the signal gaining of MRI while big size can induce brighter fluorescent imaging. In this work, we designed and fabricated novel core-porous shell structures for UCNPs with much-enhanced signal values for both fluorescent imaging and MRI. The core-porous shell UCNPs were synthesized via a post-treatment process after an inert shell was coated onto the core UCNPs. The formation mechanism was carefully investigated. The fluorescent and magnetic resonance properties have been detailed characterized and compared from core, core-shell and core-porous UCNPs. Large and bright UCNPs in fluorescence and MRI have been achieved and great potential as the dual-modal contrast agent.

scholarly journals Spatial Assessment of the Dynamics of Lactate Formation in Focal Ischemic Rat Brain

1999 ◽  
Vol 19 (4) ◽  
pp. 376-379 ◽  
Author(s):  
Rick M. Dijkhuizen ◽  
Robin A. de Graaf ◽  
Michael Garwood ◽  
Kees A. F. Tulleken ◽  
Klaas Nicolay
Keyword(s):  
Cerebral Ischemia ◽  
Magnetic Resonance ◽  
Early Identification ◽  
Focal Cerebral Ischemia ◽  
Imaging Techniques ◽  
Intervention Strategies ◽  
Ischemic Penumbra ◽  
The Core ◽  
Lactate Formation

Early identification of the potentially salvageable penumbra is critical for the determination of therapeutic intervention strategies in acute focal cerebral ischemia. This study differentiates the ischemic penumbra from the core on the basis of the dynamics of lactate formation. This was tested in a rat model of focal cerebral ischemia by infusion of [1-13C]-glucose, using lactate-edited magnetic resonance spectroscopic imaging techniques. The authors detected essentially no enrichment of lactate with 13C-label from the infused 13C-glucose in the ischemic core. However, in borderzone areas, 13C was incorporated into lactate, which could point toward compromised but potentially viable tissue. The authors' findings suggest that this combination of 13C-glucose infusion with the proposed magnetic resonance methods may aid in differentiating the penumbra from the core in cerebral ischemia.

Multifunctional β-NaGdF4:Ln3+ (Ln = Yb, Er, Dy) nanoparticles with NIR to visible upconversion and high transverse relaxivity: a potential bimodal contrast agent for high-field MRI and optical imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61443-61448 ◽  
Author(s):  
Silvanose Biju ◽  
Michael Harris ◽  
Luce Vander Elst ◽  
Marike Wolberg ◽  
Christine Kirschhock ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Optical Imaging ◽  
High Field ◽  
High Field Mri ◽  
The Core

Developed nano β-NaGdF4 doped with Yb3+/Er3+ in the core and Yb3+/Dy3+ in the shell with favorable properties for combined magnetic resonance and optical imaging.

scholarly journals In VivoImaging of Nitric Oxide by Magnetic Resonance Imaging Techniques

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Rakesh Sharma ◽  
Jeong-Won Seo ◽  
Soonjo Kwon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Nitric Oxide ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Fluorescent Imaging ◽  
Proton Relaxation ◽  
Resonance Imaging ◽  
Paramagnetic Resonance ◽  
Magnetic Resonance Imaging Mri

Nitric oxide (NO) biosensors are novel tools for real-time bioimaging of tissue oxygen changes and physiological monitoring of tissue vasculature. Nitric oxide behavior further enhances its role in mapping signal transduction at the molecular level. Spectrometric electron paramagnetic resonance (EPR) and fluorometric imaging are well known techniques with the potential forin vivobioimaging of NO. In tissues, NO is a specific target of nitrosyl compounds for chemical reaction, which provides a unique opportunity for application of newly identified NO biosensors. However, the accuracy and sensitivity of NO biosensors still need to be improved. Another potential magnetic resonance technique based on short term NO effects on proton relaxation enhancement is magnetic resonance imaging (MRI), and some NO biosensors may be used as potent imaging contrast agents for measurement of tumor size by MRI combined with fluorescent imaging. The present review provides supporting information regarding the possible use of nitrosyl compounds as NO biosensors in MRI and fluorescent bioimaging showing their measurement limitations and quantitative accuracy. These new approaches open a perspective regarding bioimaging of NO and thein vivoelucidation of NO effects by magnetic resonance techniques.

Diagnosis and Management of Cardiomyopathies – A Focus on Genetics, Cardiac Magnetic Resonance and Clinical Features

2011 ◽  
Vol 7 (3) ◽  
pp. 225
Author(s):  
Gianfranco Sinagra ◽  
Michele Moretti ◽  
Giancarlo Vitrella ◽  
Marco Merlo ◽  
Rossana Bussani ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Routine Clinical Practice ◽  
Clinical Approach ◽  
Diagnosis And Management ◽  
Made In

In recent years, outstanding progress has been made in the diagnosis and treatment of cardiomyopathies. Genetics is emerging as a primary point in the diagnosis and management of these diseases. However, molecular genetic analyses are not yet included in routine clinical practice, mainly because of their elevated costs and execution time. A patient-based and patient-oriented clinical approach, coupled with new imaging techniques such as cardiac magnetic resonance, can be of great help in selecting patients for molecular genetic analysis and is crucial for a better characterisation of these diseases. This article will specifically address clinical, magnetic resonance and genetic aspects of the diagnosis and management of cardiomyopathies.

Trends in Nanotechnology for in vivo Cancer Diagnosis: Products and Patents

2020 ◽  
Vol 26 (18) ◽  
pp. 2167-2181
Author(s):  
Tatielle do Nascimento ◽  
Melanie Tavares ◽  
Mariana S.S.B. Monteiro ◽  
Ralph Santos-Oliveira ◽  
Adriane R. Todeschini ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Quantum Dots ◽  
Magnetic Resonance ◽  
Metal Nanoparticles ◽  
Cancer Diagnosis ◽  
Imaging Techniques ◽  
Tumor Detection ◽  
Abnormal Growth ◽  
Pharmaceutical Nanotechnology

Background: Cancer is a set of diseases formed by abnormal growth of cells leading to the formation of the tumor. The diagnosis can be made through symptoms’ evaluation or imaging tests, however, the techniques are limited and the tumor detection may be late. Thus, pharmaceutical nanotechnology has emerged to optimize the cancer diagnosis through nanostructured contrast agent’s development. Objective: This review aims to identify commercialized nanomedicines and patents for cancer diagnosis. Methods: The databases used for scientific articles research were Pubmed, Science Direct, Scielo and Lilacs. Research on companies’ websites and articles for the recognition of commercial nanomedicines was performed. The Derwent tool was applied for patent research. Results: This article aimed to research on nanosystems based on nanoparticles, dendrimers, liposomes, composites and quantum dots, associated to imaging techniques. Commercialized products based on metal and composite nanoparticles, associated with magnetic resonance and computed tomography, have been observed. The research conducted through Derwent tool displayed a small number of patents using nanotechnology for cancer diagnosis. Among these patents, the most significant number was related to the use of systems based on metal nanoparticles, composites and quantum dots. Conclusion: Although few systems are found in the market and patented, nanotechnology appears as a promising field for the development of new nanosystems in order to optimize and accelerate the cancer diagnosis.

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