scholarly journals Multimodal Magnetic Resonance and Near-Infrared-Fluorescent Imaging of Intraperitoneal Ovarian Cancer Using a Dual-Mode-Dual-Gadolinium Liposomal Contrast Agent

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
M. K. Ravoori ◽  
S. Singh ◽  
R. Bhavane ◽  
A. K. Sood ◽  
B. Anvari ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
Dual Mode

scholarly journals Oxidation-responsive Eu2+/3+-liposomal contrast agent for dual-mode magnetic resonance imaging

2014 ◽  
Vol 50 (94) ◽  
pp. 14835-14838 ◽  
Author(s):  
Levi A. Ekanger ◽  
Meser M. Ali ◽  
Matthew J. Allen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Dual Mode

An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu2+ and liposomes.

scholarly journals Near-infrared fluorescent imaging of metastatic ovarian cancer using folate receptor-targeted high-density lipoprotein nanocarriers

Nanomedicine ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. 875-890 ◽  
Author(s):  
Ian R Corbin ◽  
Kenneth K Ng ◽  
Lili Ding ◽  
Andrea Jurisicova ◽  
Gang Zheng
Keyword(s):  
Ovarian Cancer ◽  
High Density Lipoprotein ◽  
Near Infrared ◽  
Folate Receptor ◽  
Density Lipoprotein ◽  
High Density ◽  
Fluorescent Imaging

scholarly journals Porous upconversion nanostructures as bimodal biomedical imaging contrast agents

2019 ◽  
Author(s):  
Ziqing Du ◽  
Abhishek Gupta ◽  
Christian Clarke ◽  
Matt Cappadana ◽  
David Clases ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agent ◽  
Imaging Techniques ◽  
Fluorescent Imaging ◽  
Lanthanide Ions ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Porous Shell ◽  
The Core ◽  
Surface Areas

AbstractLanthanide ions doped upconversion nanoparticles (UCNPs) hold great promise as the imaging contrast agent for multimodal medical imaging techniques for diagnosis, including fluorescent bioimaging, magnetic resonance imaging, and computed tomography. However, the maximized signal values of fluorescence and MRI cannot be achieved simultaneously from the same upconversion nanoparticles structures because high specific surface areas can benefit the signal gaining of MRI while big size can induce brighter fluorescent imaging. In this work, we designed and fabricated novel core-porous shell structures for UCNPs with much-enhanced signal values for both fluorescent imaging and MRI. The core-porous shell UCNPs were synthesized via a post-treatment process after an inert shell was coated onto the core UCNPs. The formation mechanism was carefully investigated. The fluorescent and magnetic resonance properties have been detailed characterized and compared from core, core-shell and core-porous UCNPs. Large and bright UCNPs in fluorescence and MRI have been achieved and great potential as the dual-modal contrast agent.

scholarly journals Multimodal Magnetic Resonance and Fluorescence Imaging of the Induced Pluripotent Stem Cell Transplantation in the Brain

2021 ◽  
Author(s):  
yunchao Zhang ◽  
Jingwen Wang ◽  
Yue Wu ◽  
Qing Tao ◽  
Feifei Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cell Therapy ◽  
Near Infrared ◽  
Fluorescent Protein ◽  
Lentiviral Vector ◽  
Induced Pluripotent Stem Cell ◽  
Fluorescent Imaging ◽  
Induced Pluripotent

Abstract BackgroundThe understanding of the engrafted cell behaviors such as the survival, growth and distribution is the prerequisite to optimize cell therapy, and a multimodal imaging at both anatomical and molecular levels is designed to achieve this goal. Methods and results We constructed a lentiviral vector carrying ferritin heavy chain 1 (FTH1), near-infrared fluorescent protein (iRFP) and enhanced green fluorescent protein (EGFP) via T2A linker, and established the induced pluripotent stem cells (iPSCs) culture stably expressing these three reporter genes. These iPSCs showed green and near-infrared fluorescence as well as the iron uptake capacity in vitro. After transplanted the labeled iPSCs into the rat brain, the engrafted cells could be in vivo imaged using magnetic resonance imaging (MRI) and near-infrared fluorescent imaging (NIF) up to 60 days at the anatomical level, moreover, these cells could be detected using EGFP immunostaining and Prussian blue stain at the cellular level. Conclusions Our study provides a novel tool to study the cellular behaviors of the transplanted cells in a multimodal way, which will be valuable for the effectiveness and safety evaluation of cell therapy.

scholarly journals New Dual Mode Gadolinium Nanoparticle Contrast Agent for Magnetic Resonance Imaging

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7628 ◽  
Author(s):  
Ketan B. Ghaghada ◽  
Murali Ravoori ◽  
Divya Sabapathy ◽  
James Bankson ◽  
Vikas Kundra ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
Dual Mode

scholarly journals Multimodal magnetic resonance and fluorescence imaging of the induced pluripotent stem cell transplantation in the brain

2021 ◽  
Author(s):  
Yunchao Zhang ◽  
Feifei Wang ◽  
Qing Tao ◽  
Nana Wang ◽  
Xingrui Gi ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cell Therapy ◽  
Near Infrared ◽  
Fluorescent Protein ◽  
Lentiviral Vector ◽  
Induced Pluripotent Stem Cell ◽  
Fluorescent Imaging ◽  
Induced Pluripotent

Abstract Objectives The understanding of the engrafted cell behaviors is the prerequisite to optimize cell therapy, and a multimodal imaging at both anatomical and molecular levels is designed to achieve this goal. Results We constructed a lentiviral vector carrying ferritin heavy chain 1 (FTH1), near-infrared fluorescent protein (iRFP) and enhanced green fluorescent protein (EGFP) via T2A linker, and established the induced pluripotent stem cells (iPSCs) culture stably expressing these three reporter genes. These iPSCs showed green and near-infrared fluorescence as well as the iron uptake capacity in vitro. After transplanted the labeled iPSCs into the rat brain, the engrafted cells could be in vivo imaged using magnetic resonance imaging (MRI) and near-infrared fluorescent imaging (NIF) up to 60 days at the anatomical level, moreover, these cells could be detected using EGFP immunostaining and Prussian blue stain at the cellular level. Conclusions Our study provides a novel tool to study the cellular behaviors of the transplanted cells in a multimodal way, which will be valuable for the effectiveness and safety evaluation of cell therapy.

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