scholarly journals Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder

2019 ◽  
Author(s):  
Jessica S. Flannery ◽  
Michael C. Riedel ◽  
Ranjita Poudel ◽  
Angela R. Laird ◽  
Thomas J. Ross ◽  
...  
Keyword(s):  
Tobacco Use ◽  
Drug Administration ◽  
Performance Feedback ◽  
Negative Reinforcement ◽  
State Level ◽  
Nicotine Withdrawal ◽  
Anterior Cingulate ◽  
Smoking History ◽  
Tobacco Use Disorder ◽  
Fmri Study

ABSTRACTAlthough tobacco use disorder is linked with functional alterations in the striatum, anterior cingulate cortex (ACC), and insula, preclinical evidence also implicates the habenula as a contributor to negative reinforcement mechanisms maintaining nicotine use. The habenula is a small and understudied epithalamic nucleus involved in reward and aversive processing that is hypothesized to be hyperactive during nicotine withdrawal thereby contributing to anhedonia. In a pharmacologic fMRI study involving administration of nicotine and varenicline, two relatively efficacious cessation aids, we utilized a positive and negative performance feedback task previously shown to differentially activate the striatum and habenula. By administering these nicotinic drugs (vs. placebos) to both overnight abstinent smokers (n=24) and nonsmokers (n=20), we delineated feedback-related functional alterations both as a function of a chronic smoking history (trait: smokers vs. nonsmokers) and as a function of drug administration (state: nicotine, varenicline). We observed that smokers showed less ventral striatal responsivity to positive feedback, an alteration not mitigated by drug administration, but rather correlated with higher trait-level addiction severity among smokers and elevated self-reported negative affect across all participants. Conversely, nicotine administration reduced habenula activity following both positive and negative feedback among abstinent smokers, but not nonsmokers; greater habenula activity correlated with elevated abstinence-induced, state-level tobacco craving among smokers and elevated social anhedonia across all participants. These outcomes highlight a dissociation between neurobiological processes linked with the trait of dependence severity and with the state of acute nicotine withdrawal. Interventions simultaneously targeting both aspects may improve currently poor cessation outcomes.One-sentence teaserIn a pharmacological fMRI study, e dissociate brain alterations in the habenula linked with nicotine withdrawal and striatal alterations linked with addiction.

scholarly journals Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder

2019 ◽  
Vol 5 (10) ◽  
pp. eaax2084 ◽  
Author(s):  
Jessica S. Flannery ◽  
Michael C. Riedel ◽  
Ranjita Poudel ◽  
Angela R. Laird ◽  
Thomas J. Ross ◽  
...  
Keyword(s):  
Drug Administration ◽  
Performance Feedback ◽  
Negative Reinforcement ◽  
State Level ◽  
Addiction Severity ◽  
Nicotine Administration ◽  
Trait Level ◽  
Positive And Negative Feedback ◽  
Aversive Processing ◽  
State Interventions

The habenula, an epithalamic nucleus involved in reward and aversive processing, may contribute to negative reinforcement mechanisms maintaining nicotine use. We used a performance feedback task that differentially activates the striatum and habenula and administered nicotine and varenicline (versus placebos) to overnight-abstinent smokers and nonsmokers to delineate feedback-related functional brain alterations both as a function of smoking trait (smokers versus nonsmokers) and drug administration state (drug versus placebo). Smokers showed less striatal responsivity to positive feedback, an alteration not mitigated by drug administration, but rather correlated with trait-level addiction severity. Conversely, nicotine administration reduced habenula activity following both positive and negative feedback among abstinent smokers, but not nonsmokers, and increased habenula activity among smokers correlated with elevated state-level tobacco cravings. These outcomes highlight a dissociation between neurobiological processes linked with the dependence severity trait and the nicotine withdrawal state. Interventions simultaneously targeting both aspects may improve currently poor cessation outcomes.

Control of the anterior cingulate/mPFC over the amygdala: a longitudinal fMRI study in patients with panic disorder

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
N Chechko ◽  
M Czisch ◽  
A Erhardt ◽  
D Hoehn ◽  
R Wehrle ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Anterior Cingulate ◽  
Fmri Study

scholarly journals Peripheral arterial stiffness during electrocutaneous stimulation is positively correlated with pain-related brain activity and subjective pain intensity: an fMRI study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Toshio Tsuji ◽  
Fumiya Arikuni ◽  
Takafumi Sasaoka ◽  
Shin Suyama ◽  
Takashi Akiyoshi ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pain Intensity ◽  
Brain Activity ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Electrocutaneous Stimulation ◽  
Pain Matrix ◽  
Fmri Study ◽  
Subjective Pain ◽  
Peripheral Arterial

AbstractBrain activity associated with pain perception has been revealed by numerous PET and fMRI studies over the past few decades. These findings helped to establish the concept of the pain matrix, which is the distributed brain networks that demonstrate pain-specific cortical activities. We previously found that peripheral arterial stiffness $${\beta }_{\text{art}}$$ β art responds to pain intensity, which is estimated from electrocardiography, continuous sphygmomanometer, and photo-plethysmography. However, it remains unclear whether and to what extent $${\beta }_{\text{art}}$$ β art aligns with pain matrix brain activity. In this fMRI study, 22 participants received different intensities of pain stimuli. We identified brain regions in which the blood oxygen level-dependent signal covaried with $${\beta }_{\text{art}}$$ β art using parametric modulation analysis. Among the identified brain regions, the lateral and medial prefrontal cortex and ventral and dorsal anterior cingulate cortex were consistent with the pain matrix. We found moderate correlations between the average activities in these regions and $${\beta }_{\text{art}}$$ β art (r = 0.47, p < 0.001). $${\beta }_{\text{art}}$$ β art was also significantly correlated with self-reported pain intensity (r = 0.44, p < 0.001) and applied pain intensity (r = 0.43, p < 0.001). Our results indicate that $${\beta }_{\text{art}}$$ β art is positively correlated with pain-related brain activity and subjective pain intensity. This study may thus represent a basis for adopting peripheral arterial stiffness as an objective pain evaluation metric.

Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance

2003 ◽  
Vol 33 (3) ◽  
pp. 455-467 ◽  
Author(s):  
F. C. MURPHY ◽  
A. MICHAEL ◽  
T. W. ROBBINS ◽  
B. J. SAHAKIAN
Keyword(s):  
Working Memory ◽  
Negative Feedback ◽  
Performance Feedback ◽  
Visual Discrimination ◽  
Negative Reinforcement ◽  
Spatial Working Memory ◽  
Memory Task ◽  
Depressive Illness ◽  
Reversal Task ◽  
Depressed Patients

Background. Recent evidence suggests that an abnormal response to performance feedback may contribute to the wide-ranging neuropsychological deficits typically associated with depressive illness. The present research sought to determine whether the inability of depressed patients to utilize performance feedback advantageously is equally true for accurate and misleading feedback.Method. Patients with major depression and matched controls completed: (1) a visual discrimination and reversal task that featured intermittent and misleading negative feedback; and (2) feedback and no-feedback versions of a computerised test of spatial working memory. In the feedback version, negative feedback was accurate, highly informative, and could be used as a mnemonic aid.Results. On the Probability Reversal task, depressed patients were impaired in their ability to maintain response set in the face of misleading negative feedback as shown by their increased tendency to switch responding to the ‘incorrect’ stimulus following negative reinforcement, relative to that of controls. Patients' ability to acquire and reverse the necessary visual discrimination was unimpaired. On the Spatial Working Memory task, depressed patients made significantly more between-search errors than controls on the most difficult trials, but their ability to use negative feedback to facilitate performance remained intact.Conclusions. The present results suggest that feedback can have different effects in different contexts. Misleading, negative feedback appears to disrupt the performance of depressed patients, whereas negative but accurate feedback does not. These findings are considered in the context of recent studies on reinforcement systems and their associated neurobiological substrates.

Tobacco Use Disorder and Cardiovascular Health

Addiction ◽  
2021 ◽  
Author(s):  
Neal L. Benowitz ◽  
Evangelia Liakoni
Keyword(s):  
Tobacco Use ◽  
Cardiovascular Health ◽  
Tobacco Use Disorder

Tobacco Use Is Associated with More Severe Adverse Outcomes Than Morbid Obesity after Aseptic Revision TKA

2021 ◽  
Author(s):  
Michael P. Hagerty ◽  
Rafael Walker-Santiago ◽  
Jason D. Tegethoff ◽  
Benjamin M. Stronach ◽  
James A. Keeney
Keyword(s):  
Risk Factors ◽  
Morbid Obesity ◽  
Tobacco Use ◽  
Adverse Outcomes ◽  
Smoking History ◽  
Morbidly Obese ◽  
Knee Amputation ◽  
Increased Risk ◽  
Aseptic Revision ◽  
Component Revision

AbstractThe association of morbid obesity with increased revision total knee arthroplasty (rTKA) complications is potentially confounded by concurrent risk factors. This study was performed to evaluate whether morbid obesity was more strongly associated with adverse aseptic rTKA outcomes than diabetes or tobacco use history—when present as a solitary major risk factor. Demographic characteristics, surgical indications, and adverse outcomes (reoperation, revision, infection, and amputation) were compared between 270 index aseptic rTKA performed for patients with morbid obesity (n = 73), diabetes (n = 72), or tobacco use (n = 125) and 239 “healthy” controls without these risk factors at a mean 75.7 (range: 24–111) months. There was no difference in 2-year reoperation rate (17.8 vs. 17.6%, p = 1.0) or component revision rate (8.2 vs. 8.4%) between morbidly obese and healthy patients. However, higher reoperation rates were noted in patients with diabetes (p = 0.02) and tobacco use history (p < 0.01), including higher infection (p < 0.05) and above knee amputation (p < 0.01) rates in patients with tobacco use history. Multivariate analysis retained an independent association between smoking history and amputation risk (odds ratio: 7.4, 95% confidence interval: 1.7–55.2, p < 0.01). Morbid obesity was not associated with an increased risk of reoperation or component revision compared with healthy patients undergoing aseptic revision. Tobacco use was associated with increased reoperation and above knee amputation. Additional study will be beneficial to determine whether risk reduction efforts are effective in mitigating postoperative complication risks.

scholarly journals Altered fear processing in adolescents with a history of severe childhood maltreatment: an fMRI study

2018 ◽  
Vol 48 (7) ◽  
pp. 1092-1101 ◽  
Author(s):  
H. Hart ◽  
L. Lim ◽  
M. A. Mehta ◽  
A. Simmons ◽  
K. A. H. Mirza ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Functional Connectivity ◽  
Childhood Maltreatment ◽  
Emotion Processing ◽  
Anterior Cingulate ◽  
Healthy Controls ◽  
Neural Basis ◽  
Fmri Study ◽  
History Of ◽  
Psychiatric Conditions

AbstractBackgroundChildren with a history of maltreatment suffer from altered emotion processing but the neural basis of this phenomenon is unknown. This pioneering functional magnetic resonance imaging (fMRI) study investigated the effects of severe childhood maltreatment on emotion processing while controlling for psychiatric conditions, medication and substance abuse.MethodTwenty medication-naive, substance abuse-free adolescents with a history of childhood abuse, 20 psychiatric control adolescents matched on psychiatric diagnoses but with no maltreatment and 27 healthy controls underwent a fMRI emotion discrimination task comprising fearful, angry, sad happy and neutral dynamic facial expressions.ResultsMaltreated participants responded faster to fearful expressions and demonstrated hyper-activation compared to healthy controls of classical fear-processing regions of ventromedial prefrontal cortex (vmPFC) and anterior cingulate cortex, which survived at a more lenient threshold relative to psychiatric controls. Functional connectivity analysis, furthermore, demonstrated reduced connectivity between left vmPFC and insula for fear in maltreated participants compared to both healthy and psychiatric controls.ConclusionsThe findings show that people who have experienced childhood maltreatment have enhanced fear perception, both at the behavioural and neurofunctional levels, associated with enhanced fear-related ventromedial fronto-cingulate activation and altered functional connectivity with associated limbic regions. Furthermore, the connectivity adaptations were specific to the maltreatment rather than to the developing psychiatric conditions, whilst the functional changes were only evident at trend level when compared to psychiatric controls, suggesting a continuum. The neurofunctional hypersensitivity of fear-processing networks may be due to childhood over-exposure to fear in people who have been abused.

Assessing sex, gender identity, sexual orientation, race, ethnicity, socioeconomic status, and mental health concerns in tobacco use disorder treatment research: Measurement challenges and recommendations from a Society for Research on Nicotine and Tobacco (SRNT) pre-conference workshop

2021 ◽  
Author(s):  
Andrea H Weinberger ◽  
Marc L Steinberg ◽  
Sarah D Mills ◽  
Sarah S Dermody ◽  
Jaimee L Heffner ◽  
...  
Keyword(s):  
Mental Health ◽  
Socioeconomic Status ◽  
Sexual Orientation ◽  
Gender Identity ◽  
Tobacco Use ◽  
Health Concerns ◽  
Tobacco Use Disorder ◽  
Lower Socioeconomic ◽  
Treatment Research ◽  
Mental Health Concerns

Abstract This paper reports on topics discussed at a Society for Research on Nicotine and Tobacco (SRNT) pre-conference workshop at the 2019 annual SRNT meeting. The goal of the preconference workshop was to help develop a shared understanding of the importance of several tobacco-related priority groups in tobacco use disorder treatment research and to highlight challenges in measurement related to these groups. The workshop focused on persons with minoritized sex, gender identity, and sexual orientation identities; persons with minoritized racial and ethnic backgrounds; persons with lower socioeconomic status (SES); and persons with mental health concerns. In addition to experiencing commercial tobacco-related health disparities, these groups are also underrepresented in tobacco research, including tobacco use disorder (TUD) treatment studies. Importantly, there is wide variation in how and whether researchers are identifying variation within these priority groups. Best practices for measuring and reporting sex, gender identity, sexual orientation, race, ethnicity, SES, and mental health concerns in TUD treatment research are needed. This paper provides information about measurement challenges when including these groups in TUD treatment research and specific recommendations about how to measure these groups and assess potential disparities in outcomes. The goal of this paper is to encourage TUD treatment researchers to use measurement best practices in these priority groups in an effort to conduct meaningful and equity-promoting research. Increasing the inclusion and visibility of these groups in TUD treatment research will help to move the field forward in decreasing tobacco-related health disparities. Implications Tobacco-related disparities exist for a number of priority groups including, among others, women, individuals with minoritized sexual and gender identities, individuals with minoritized racial and ethnic backgrounds, individuals with lower socioeconomic status, and individuals with mental health concerns. Research on tobacco use disorder (TUD) treatments for many of these subgroups is lacking. Accurate assessment and consideration of these subgroups will provide needed information about efficacious and effective TUD treatments, about potential mediators and moderators, and for accurately describing study samples, all critical elements for reducing tobacco-related disparities, and improving diversity, equity, and inclusion in TUD treatment research.

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