scholarly journals Shared dynamic functional connectivity across schizophrenia, bipolar disorder and major depressive disorder

2019 ◽  
Author(s):  
Chao Li ◽  
Ke Xu ◽  
Mengshi Dong ◽  
Yange Wei ◽  
Jia Duan ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Dynamic Functional Connectivity ◽  
State Dependent ◽  
Window Method ◽  
Assessment And Treatment ◽  
Post Hoc

AbstractDynamic functional connectivity (DFC) analysis can capture time-varying properties of connectivity and may provide further information about transdiagnostic psychopathology across major psychiatric disorders. In this study, we used resting state functional MRI and a sliding-window method to study DFC in 150 schizophrenia (SZ), 100 bipolar disorder(BD), 150 major depressive disorder (MDD), and 210 healthy controls (HC). DFC were clustered into two functional connectivity states. Significant 4-group differences in DFC were found only in state 2. Post hoc analyses showed that transdiagnostic dysconnectivity among there disorders featured decreased connectivity within visual, somatomotor, salience and frontoparietal networks. Our results suggest that decreased connectivity within both lower-order (visual and somatomotor) and higher-order (salience and frontoparietal) networks may serve as transdiagnostic marker of these disorders, and that these dysconnectivity is state-dependent. Targeting these dysconnectivity may improve assessment and treatment for patients that having more than one of these disorders at the same time.

Visuospatial planning in unmedicated major depressive disorder and bipolar disorder: distinct and common neural correlates

2016 ◽  
Vol 46 (11) ◽  
pp. 2313-2328 ◽  
Author(s):  
M. M. Rive ◽  
M. W. J. Koeter ◽  
D. J. Veltman ◽  
A. H. Schene ◽  
H. G. Ruhé
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Executive Functioning ◽  
Depressive Disorder ◽  
Blood Oxygen Level Dependent ◽  
Blood Oxygen Level ◽  
Everyday Functioning ◽  
Major Depressive ◽  
State Dependent ◽  
Post Hoc

BackgroundCognitive impairments are an important feature of both remitted and depressed major depressive disorder (MDD) and bipolar disorder (BD). In particular, deficits in executive functioning may hamper everyday functioning. Identifying the neural substrates of impaired executive functioning would improve our understanding of the pathophysiology underlying these disorders, and may eventually aid in discriminating between MDD and BD, which is often difficult during depression and remission. To date, mostly medicated MDD and BD subjects have been investigated, which may have influenced results. Therefore, we investigated executive functioning in medication-free depressed and remitted MDD and BD subjects.MethodWe used the Tower of London (ToL) visuospatial planning task to assess behavioural performance and blood oxygen-level dependent responses in 35 healthy controls, 21 remitted MDD, 23 remitted BD, 19 depressed MDD and nine depressed BD subjects.ResultsVisuospatial planning per se was associated with increased frontostriatal activity in depressed BD compared to depressed MDD. In addition, post-hoc analyses indicated that visuospatial planning load was associated with increased parietal activity in depressed compared to remitted subjects, and BD compared to MDD subjects. Task performance did not significantly differ between groups.ConclusionsMore severely affected, medication-free mood disorder patients require greater parietal activity to perform in visuospatial planning, which may be compensatory to maintain relatively normal performance. State-dependent frontostriatal hyperactivity during planning may be a specific BD characteristic, providing clues for further characterization of differential pathophysiology in MDD v. BD. This could potentially provide a biomarker to aid in the differentiation of these disorders.

Altered dynamic functional connectivity in weakly-connected state in major depressive disorder

2019 ◽  
Vol 130 (11) ◽  
pp. 2096-2104 ◽  
Author(s):  
Zhijun Yao ◽  
Jie Shi ◽  
Zhe Zhang ◽  
Weihao Zheng ◽  
Tao Hu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Dynamic Functional Connectivity

scholarly journals Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

2016 ◽  
Vol 37 (8) ◽  
pp. 2918-2930 ◽  
Author(s):  
Murat Demirtaş ◽  
Cristian Tornador ◽  
Carles Falcón ◽  
Marina López‐Solà ◽  
Rosa Hernández‐Ribas ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Dynamic Functional Connectivity

Cerebellar-cerebral dynamic functional connectivity alterations in major depressive disorder

2020 ◽  
Vol 275 ◽  
pp. 319-328 ◽  
Author(s):  
Dao-min Zhu ◽  
Ying Yang ◽  
Yu Zhang ◽  
Chunli Wang ◽  
Yajun Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Dynamic Functional Connectivity
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