scholarly journals Abnormal dynamic functional connectivity of amygdalar subregions in untreated patients with first-episode major depressive disorder

2018 ◽  
Vol 43 (4) ◽  
pp. 262-272 ◽  
Author(s):  
Lihua Qiu ◽  
Mingrui Xia ◽  
Bochao Cheng ◽  
Lin Yuan ◽  
Weihong Kuang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
First Episode ◽  
Major Depressive ◽  
Dynamic Functional Connectivity

scholarly journals Altered Static and Dynamic Functional Connectivity of Habenula Associated With Suicidal Ideation in First-Episode, Drug-Naïve Patients With Major Depressive Disorder

2020 ◽  
Vol 11 ◽  
Author(s):  
Dan Qiao ◽  
Aixia Zhang ◽  
Ning Sun ◽  
Chunxia Yang ◽  
Jianying Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Suicidal Ideation ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Region Of Interest ◽  
Neural Circuitry ◽  
First Episode ◽  
Major Depressive ◽  
Dynamic Functional Connectivity ◽  
Drug Naïve

Investigating the neurobiological mechanism of suicidal ideation (SI) in major depressive disorder (MDD) may be beneficial to prevent the suicidal behavior. Mounting evidence showed that habenula contributed to the etiology of MDD. The habenula is a key brain region that links the forebrain to midbrain, crucial for the processing of reward and aversion. The aim of the present study was to identify whether first-episode, drug-naive MDD patients with SI displayed altered habenula neural circuitry. Forty-three and 38 drug-naïve patients with first-episode MDD with or without SI (SI+/– group) and 35 healthy control subjects (HC) underwent resting-state functional magnetic resonance imaging. The whole-brain habenula static (sFC) and dynamic functional connectivity (dFC) were calculated to identify regions showing significant difference among these three groups followed by region of interest to region of interest post hoc analysis. For sFC, compared with SI– and HC groups, SI+ group showed decreased sFC from habenula to the precuneus and the inferior frontal gyrus. Patients with MDD displayed increased sFC from habenula to the putamen but decreased sFC to the precentral gyrus. For dFC, SI+ group showed increased dFC from habenula to the superior temporal gyrus, the precuneus, but decreased dFC to the lingual gyrus, the postcentral gyrus, when comparing with SI– and HC groups. Patients with MDD, regardless of SI, displayed decreased dFC from the habenula to the angular gyrus. These findings provide evidence that SI in first-episode, drug-naïve patients with MDD may be related to an abnormality in habenula neural circuitry, which may provide the theoretical basis of novel treatments.

Altered dynamic functional connectivity in weakly-connected state in major depressive disorder

2019 ◽  
Vol 130 (11) ◽  
pp. 2096-2104 ◽  
Author(s):  
Zhijun Yao ◽  
Jie Shi ◽  
Zhe Zhang ◽  
Weihao Zheng ◽  
Tao Hu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Dynamic Functional Connectivity

scholarly journals Dynamic functional connectivity reveals altered variability in functional connectivity among patients with major depressive disorder

2016 ◽  
Vol 37 (8) ◽  
pp. 2918-2930 ◽  
Author(s):  
Murat Demirtaş ◽  
Cristian Tornador ◽  
Carles Falcón ◽  
Marina López‐Solà ◽  
Rosa Hernández‐Ribas ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Dynamic Functional Connectivity
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