scholarly journals Zika virus seroprevalence declines and neutralization antibodies wane in adults following outbreaks in French Polynesia and Fiji

2019 ◽  
Author(s):  
Alasdair D Henderson ◽  
Maite Aubry ◽  
Mike Kama ◽  
Jessica Vanhomwegen ◽  
Anita Teissier ◽  
...  
Keyword(s):  
Latin America ◽  
Zika Virus ◽  
French Polynesia ◽  
Cross Sectional ◽  
The Pacific ◽  
Before And After ◽  
Dynamics Of Population ◽  
High Level ◽  
Antibody Levels

SUMMARYBackgroundSerosurveys published following major outbreaks of Zika virus (ZIKV) have so far shown a high level of seroprevalence from samples collected within 12 months of the first confirmed case. A common assumption is that ZIKV infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for many years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented.MethodsWe compared results from eight serological surveys, with sample sizes ranging from 49 to 700, before and after known ZIKV outbreaks in the Pacific region: five from cross-sectional studies of schoolchildren and the general population in French Polynesia over a seven-year period; and three from a longitudinal cohort in Fiji over a four-year period.FindingsWe found strong evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. In the cohort in Fiji, there was also a significant decline in antibody titres against ZIKV. However, the decline in seroprevalence was concentrated in adults, while high seroprevalence persisted in children.InterpretationThe observed patterns of long-term anti-ZIKV antibody levels following outbreaks in the Pacific could be an early indication of the dynamics of population immunity in Latin America. Given that ZIKV antibody levels can wane substantially over time, follow-up seroprevalence studies and prospective clinical trial designs in Latin America may need to be revised, and assumptions about the potential for ZIKV to re-emerge may need to be revisited.FundingPacific Funds, ANR, MRC, Wellcome, Royal Society.

scholarly journals Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Alasdair D Henderson ◽  
Maite Aubry ◽  
Mike Kama ◽  
Jessica Vanhomwegen ◽  
Anita Teissier ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
French Polynesia ◽  
Significant Decline ◽  
High Seroprevalence ◽  
Zikv Infection ◽  
Cross Sectional ◽  
Before And After ◽  
Antibody Titres

It has been commonly assumed that Zika virus (ZIKV) infection confers long-term protection against reinfection, preventing ZIKV from re-emerging in previously affected areas for several years. However, the long-term immune response to ZIKV following an outbreak remains poorly documented. We compared results from eight serological surveys before and after known ZIKV outbreaks in French Polynesia and Fiji, including cross-sectional and longitudinal studies. We found evidence of a decline in seroprevalence in both countries over a two-year period following first reported ZIKV transmission. This decline was concentrated in adults, while high seroprevalence persisted in children. In the Fiji cohort, there was also a significant decline in neutralizing antibody titres against ZIKV, but not against dengue viruses that circulated during the same period.

scholarly journals Transmission dynamics of Zika virus in island populations: a modelling analysis of the 2013-14 French Polynesia outbreak

2016 ◽  
Author(s):  
Adam J. Kucharski ◽  
Sebastian Funk ◽  
Rosalind M. Eggo ◽  
Henri-Pierre Mallet ◽  
W. John Edmunds ◽  
...  
Keyword(s):  
South America ◽  
Dengue Virus ◽  
Zika Virus ◽  
French Polynesia ◽  
Neurological Complications ◽  
Transmission Dynamics ◽  
Guillain Barre Syndrome ◽  
Island Populations ◽  
The Pacific ◽  
Guillain Barré

AbstractBetween October 2013 and April 2014, more than 30,000 cases of Zika virus (ZIKV) disease were estimated to have attended healthcare facilities in French Polynesia. ZIKV has also been reported in Africa and Asia, and in 2015 the virus spread to South America and the Caribbean. Infection with ZIKV has been associated with neurological complications including Guillain-Barré Syndrome (GBS) and microcephaly, which led the World Health Organization to declare a Public Health Emergency of International Concern in February 2015. To better understand the transmission dynamics of ZIKV, we used a mathematical model to examine the 2013–14 outbreak on the six major archipelagos of French Polynesia. Our median estimates for the basic reproduction number ranged from 2.6–4.8, with an estimated 11.5% (95% CI: 7.32–17.9%) of total infections reported. As a result, we estimated that 94% (95% CI: 91–97%) of the total population of the six archipelagos were infected during the outbreak. Based on the demography of French Polynesia, our results imply that if ZIKV infection provides complete protection against future infection, it would take 12–20 years before there are a sufficient number of susceptible individuals for ZIKV to reemerge, which is on the same timescale as the circulation of dengue virus serotypes in the region. Our analysis suggests that ZIKV may exhibit similar dynamics to dengue virus in island populations, with transmission characterized by large, sporadic outbreaks with a high proportion of asymptomatic or unreported cases.Author SummarySince the first reported major outbreak of Zika virus disease in Micronesia in 2007, the virus has caused outbreaks throughout the Pacific and South America. Transmitted by the Aedes species of mosquitoes, the virus has been linked to possible neurological complications including Guillain-Barre Syndrome and microcephaly. To improve our understanding of the transmission dynamics of Zika virus in island populations, we analysed the 2013–14 outbreak on the six major archipelagos of French Polynesia. We found evidence that Zika virus infected the majority of population, but only around 12% of total infections on the archipelagos were reported as cases. If infection with Zika virus generates lifelong immunity, we estimate that it would take at least 15–20 years before there are enough susceptible people for the virus to reemerge. Our results suggest that Zika virus could exhibit similar dynamics to dengue virus in the Pacific, producing large but sporadic outbreaks in small island populations.

The impact of knowledge and motivation management on creativity

2017 ◽  
Vol 39 (5) ◽  
pp. 732-752 ◽  
Author(s):  
Lucía Muñoz-Pascual ◽  
Jesús Galende
Keyword(s):  
Employee Behavior ◽  
Employee Creativity ◽  
Cross Sectional ◽  
Content Type ◽  
Joint Influence ◽  
Long Term Impact ◽  
High Level ◽  
The Impact ◽  
Practical Implications

Purpose The purpose of this paper is to analyze the influence that two variables related to human resources (HR) have on employee creativity – namely, knowledge management (KM) and motivation management (MM). Design/methodology/approach The linear regression analyses are based on a sample of 306 employees from 11 Spanish companies belonging to three innovative clusters. In addition, “creativity” is considered an antecedent of technological innovation. Findings KM and intrinsic MM are shown to inform creativity, whereas extrinsic MM has no such effect. Practical implications Although this study is based on cross-sectional data, the findings might induce researchers to investigate the effects of other HR variables, such as the types of relations between employees and their long-term impact on creativity. Management should encourage KM and intrinsic MM across employees, as the results indicate that tacit KM, explicit KM and intrinsic MM encourage a positive attitude toward creativity among employees. Originality/value The main contribution is new empirical evidence on the joint influence of aptitudes (KM) and attitudes (MM) on employee creativity. In addition, the study includes a key measure of employee creativity. The evidence reveals the types of KM and MM that encourage or inhibit creative employee behavior. The results show that once employees have reached a medium-high level of extrinsic MM, creativity will be affected solely by intrinsic MM.

scholarly journals Long term evolution of soft tissue response in the fingers of high-level sport climbers: A cross-sectional 10 Year follow-up study

2021 ◽  
Vol 52 ◽  
pp. 173-179
Author(s):  
Stefan Fröhlich ◽  
Andreas Schweizer ◽  
Lisa Reissner ◽  
Tatjana Pastor ◽  
Jörg Spörri ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Long Term Evolution ◽  
Tissue Response ◽  
Cross Sectional ◽  
Follow Up Study ◽  
Term Evolution ◽  
Soft Tissue Response ◽  
High Level

scholarly journals Zika virus: a new pandemic threat

2016 ◽  
Vol 10 (03) ◽  
pp. 201-207 ◽  
Author(s):  
Ahmed Ali Al-Qahtani ◽  
Nyla Nazir ◽  
Mashael R. Al-Anazi ◽  
Salvatore Rubino ◽  
Mohammed N. Al-Ahdal
Keyword(s):  
Zika Virus ◽  
Blood Donation ◽  
French Polynesia ◽  
Western Hemisphere ◽  
Zikv Infection ◽  
Rapid Spread ◽  
Screening And Identification ◽  
Pandemic Threat ◽  
Contaminated Blood

Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family and is related to dengue, Chikungunya, West Nile, yellow fever, and Japanese encephalitis viruses. ZIKV was first discovered in Uganda in 1947. Different species of mosquito from the Aedes genus, mainly A. aegypti and A. albopictus are the vectors responsible for ZIKV infection in humans. It is also reported that ZIKV is transmitted congenitally, sexually, and through blood donation. Until recently, ZIKV outbreaks were sporadic and self-limiting. The first large epidemic was reported from Yap Island in 2007 followed by an outbreak of Zika fever in French Polynesia in 2013. Brazil is the epicenter of the current ZIKV epidemic which is rapidly spreading across the Americas. ZIKV infection remained relatively less studied in view of its low case numbers, and low clinical impact relative to other arboviruses. However, all this is set to change with its rapid spread in the Western hemisphere and suspected complications particularly microcephaly in newborn babies with ZIKV infected mothers. ZIKV is expected to substantially add to both short-term and long-term economic burden of the effected countries. Due to the large number of people travelling across the borders and some reported cases of transmission of ZIKV via contaminated blood, screening and identification of asymptomatic infected individuals are important.

scholarly journals How Did Zika Virus Emerge in the Pacific Islands and Latin America?

mBio ◽  
2016 ◽  
Vol 7 (5) ◽  
Author(s):  
John H.-O. Pettersson ◽  
Vegard Eldholm ◽  
Stephen J. Seligman ◽  
Åke Lundkvist ◽  
Andrew K. Falconar ◽  
...  
Keyword(s):  
Latin America ◽  
Amino Acid ◽  
Zika Virus ◽  
Reverse Genetics ◽  
Pacific Islands ◽  
Vector Competence ◽  
Phylogenetic Analyses ◽  
Human Populations ◽  
Amino Acid Substitutions ◽  
The Pacific

ABSTRACT The unexpected emergence of Zika virus (ZIKV) in the Pacific Islands and Latin America and its association with congenital Zika virus syndrome (CZVS) (which includes microcephaly) and Guillain-Barré syndrome (GBS) have stimulated wide-ranging research. High densities of susceptible Aedes spp., immunologically naive human populations, global population growth with increased urbanization, and escalation of global transportation of humans and commercial goods carrying vectors and ZIKV undoubtedly enhanced the emergence of ZIKV. However, flavivirus mutations accumulate with time, increasing the likelihood that genetic viral differences are determinants of change in viral phenotype. Based on comparative ZIKV complete genome phylogenetic analyses and temporal estimates, we identify amino acid substitutions that may be associated with increased viral epidemicity, CZVS, and GBS. Reverse genetics, vector competence, and seroepidemiological studies will test our hypothesis that these amino acid substitutions are determinants of epidemic and neurotropic ZIKV emergence.

scholarly journals Quantifying long-term evolution of intra-urban spatial interactions

2015 ◽  
Vol 12 (102) ◽  
pp. 20141089 ◽  
Author(s):  
Lijun Sun ◽  
Jian Gang Jin ◽  
Kay W. Axhausen ◽  
Der-Horng Lee ◽  
Manuel Cebrian
Keyword(s):  
Community Structure ◽  
Transport Cost ◽  
Spatial Interactions ◽  
Cross Sectional ◽  
Line Extension ◽  
Before And After ◽  
Spatial Reorganization ◽  
Long Term Impact ◽  
The Impact

Understanding the long-term impact that changes in a city's transportation infrastructure have on its spatial interactions remains a challenge. The difficulty arises from the fact that the real impact may not be revealed in static or aggregated mobility measures, as these are remarkably robust to perturbations. More generally, the lack of longitudinal, cross-sectional data demonstrating the evolution of spatial interactions at a meaningful urban scale also hinders us from evaluating the sensitivity of movement indicators, limiting our capacity to understand the evolution of urban mobility in depth. Using very large mobility records distributed over 3 years, we quantify the impact of the completion of a metro line extension: the Circle Line (CCL) in Singapore. We find that the commonly used movement indicators are almost identical before and after the project was completed. However, in comparing the temporal community structure across years, we do observe significant differences in the spatial reorganization of the affected geographical areas. The completion of CCL enables travellers to re-identify their desired destinations collectively with lower transport cost, making the community structure more consistent. These changes in locality are dynamic and characterized over short timescales, offering us a different approach to identify and analyse the long-term impact of new infrastructures on cities and their evolution dynamics.

Planning and Health Policy in Finland

1972 ◽  
Vol 2 (1) ◽  
pp. 23-34 ◽  
Author(s):  
A. S. Härö ◽  
T. Purola
Keyword(s):  
Social Background ◽  
Point Of View ◽  
Decision Makers ◽  
Present System ◽  
Centralized Control ◽  
Related Information ◽  
Before And After ◽  
Health Related ◽  
High Level

The health services system in Finland is analyzed from the point of view of planning–oriented activities. Society has traditionally been the main provider of services in this country, and executive responsibilities of local autonomous authorities are balanced with the centralized control carried out by legislative measures and subsidies. An organized information system is a prerequisite to planning (this is especially true in a country with Finland's type of organizational structure). The Finnish system is based on problem–oriented data banks. Health interview surveys which link social background data with health–related information have a key role in this system; these surveys are well suited to before and after comparisons. Information is capable of producing action only if it is properly analyzed and timed. In order to obtain information about actual goal expectations of the decision–makers, the special–purpose planning departments are located at a high level of government in Finland. Typical methods of implementation, such as financial subsidies, are described in this paper, and economic estimates and long–term budgeting are given as examples of guides for the central authorities. The use of before and after studies to measure the effect of the policies is described, and some observations on the weaknesses in the present system are presented.

scholarly journals Hunger in Latin America: What Can We Do?

2019 ◽  
Vol 34 (s1) ◽  
pp. s94-s94
Author(s):  
Silvana Dal Ponte ◽  
Daniel Menezes
Keyword(s):  
Latin America ◽  
Climate Changes ◽  
Cross Sectional Study ◽  
World Health ◽  
Sectional Study ◽  
Cross Sectional ◽  
Food And Nutrition ◽  
The World ◽  
The Caribbean

Introduction:Hunger is a global problem and has increased in recent years. In Latin America, hunger continues in high numbers. Although the level of hunger is relatively low compared to other regions, this increase in Latin America is mainly explained by the economic slowdown in South America. Also, climate changes are already weakening the production of the main crops in tropical and temperate regions.Aim:Report the numbers of hunger in Latin America.Methods:A cross-sectional study with reports of the World Health Organization’s hunger figures, September 2018.Results:The number of hungry people in the world has increased for the third consecutive year and affects 821 million people, according to a report released by UN agencies. This corresponds to one in nine people in the world. In Brazil, the figures indicate that more than 5.2 million people spent a day or more without consuming food by 2017, which corresponds to 2.5% of the population. In Latin America and the Caribbean, hunger has also increased and affects some 39 million people.Discussion:Hunger is a catastrophic problem in Latin America. Involving professionals in food and nutrition to try to reduce these numbers appears to be a good strategy because just as the doctor treats the disease, the involvement of other specialists to address the cause of the problem can bring long-term benefits. A social project for this purpose that mobilizes chefs and nutritionists is in progress in Brazil.

scholarly journals Triiodothyronin, Thyroxine and Thyrotropin in Vitiligo

2012 ◽  
Vol 9 (2) ◽  
pp. 7-10
Author(s):  
K Subba ◽  
D Karn ◽  
R Khatri
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Cross Sectional Study ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Age Group ◽  
Cross Sectional ◽  
Function Test ◽  
High Level

BackgroundVitiligo is a common pigmentary disorder of the skin, affecting individuals globally. Not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. ObjectiveThe aim of this study is to find out the situations of abnormal thyroid function test (TFT) in vitiligo patients. MethodsA prospective cross sectional study was conducted at the Dhulikhel Hospital, KUTH, Dhulikhel during November 2008 to January 2011 with the objective to assess the thyroid function tests in vitiligo patients. ResultsTotal 66 vitiligo patients with male 30 (45%) and female 36 (55%). Total 26 (39.39%) vitiligo patients have been found to have abnormal thyroid function test. Among them 10 had abnormal T3, seven had abnormal T4 and 12 had abnormal TSH level. Thyroid function test were normal in other vitiligo patients. Total seven vitiligo had high level of T3 than normal value, four male and three female. Two had higher level of T4 above 2.0 ng/dl and all were male, while five had abnormally low level of T4 with three male and two female. There were seven vitiligo patient with increased T3 level and three with decreased T3 level, among them six were males and four were females, the age group was ranged from seven to 68 years old. The T4 level were found abnormal in seven vitiligo patients among which five were males and two were females with the age group ranging from 7 to 51 years. ConclusionsThere has been significant association of thyroid disorder in the patient with vitiligo. Therefore, patient with vitiligo need to undergo thyroid function test to rule out the thyroid disorder and prevent from long-term complications.DOI: http://dx.doi.org/10.3126/kumj.v9i2.6279Kathmandu Univ Med J 2011;9(2):7-10 

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