scholarly journals Impact of pterygium on the ocular surface and meibomian glands

2019 ◽  
Author(s):  
Ana Cláudia Viana Wanzeler ◽  
Italo Antunes França Barbosa ◽  
Bruna Duarte ◽  
Eduardo Buzolin Barbosa ◽  
Daniel Almeida Borges ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Lower Eyelid ◽  
Meibomian Gland ◽  
Conjunctival Hyperemia ◽  
Upper Eyelid ◽  
Film Stability ◽  
Surface Parameters ◽  
Meibomian Glands ◽  
The Impact

AbstractPurposeTo analyze how ocular surface parameters correlate to pterygium and investigate the possible impact on tear film and meibomian glands.Methodswe investigated objective parameters of the ocular surface such as conjunctival hyperemia, tear film stability and volume, meibomian gland dysfunction, dry eye disease, corneal topography comparing healthy individuals and correlating with the pterygium clinical presentation.ResultsA total of 83 patients were included. Corneal astigmatism induction was 2.65 ± 2.52 D (0.4-11.8). The impact of pterygium on the ocular surface parameters compared to matched controls was seen in: conjunctival hyperemia (control 1.55±0.39/pterygium 2.14±0.69; p=0.0001), tear meniscus height (control 0.24±0.05 mm/pterygium 0.36±0.14mm; p 0.0002), meiboscore lower eyelid (control 0.29±0.64/pterygium 1.38±0.95; p 0.0001) and meiboscore upper eyelid (control 0.53±0.62/pterygium 0.98±0.75; p=0.0083). We found a high number of pterygium patients (88%) presented meibomian gland alterations. Interestingly, meibomian gland loss was coincident to the localization of the pterygium in 54% of the upper and 77% lower lids.ConclusionPterygium greatly impacts on ocular surface by inducing direct alterations in the pattern of meibomian glands besides corneal irregularities, conjunctival hyperemia and lacrimal film alterations, inducing significant symptoms and potential signs of dysfunction.

scholarly journals Noncontact Meibography in Patients with Keratoconus

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Engy Mohamed Mostafa ◽  
Marwa Mahmoud Abdellah ◽  
Ashraf Mostafa Elhawary ◽  
Amr Mounir
Keyword(s):  
Morphological Changes ◽  
Tear Film ◽  
Cost Effective ◽  
Lower Eyelid ◽  
Meibomian Gland ◽  
Control Group ◽  
Schirmer Test ◽  
Ocular Surface Disease Index ◽  
Meibomian Glands ◽  
Grade 3

Purpose. To examine the morphological changes in the meibomian glands of patients with keratoconus as well as to study the relationship between these changes in the morphology and several tear film parameters. Methods. Examination of the meibomian gland (MG) of 300 keratoconus patients presenting to the center using infrared noncontact meibography system (Sirius, CSO, Italy) between January 2017—January 2019. 100 eyes of healthy individuals were also enrolled as a control group. Tear breakup time (TBUT) test and Schirmer test II were evaluated. Subjective symptoms were also assessed using Ocular Surface Disease Index (OSDI). Results. Mean age of keratoconus patients was 19 ± 12 years and 21 ± 14 years in control group. Average TBUT was 4.9 ± 2.1 sec. and average Schirmer test was 5.3 ± 2.2 mm which was significantly lower than control group (p=0.05). Meibomian gland dropout in the lower eyelid of the keratoconus group was as follows: grade 0 (no loss of meibomian glands): 100 eyes; grade 1 (gland dropout area <1/3 of the total meibomian glands): 85 eyes; grade 2 (gland dropout area 1/3 to 2/3): 68 eyes; and grade 3 (gland dropout >2/3): 47 eyes. Conclusion. Keratoconus shows significant meibomian gland dropout and distortion that can be recorded by noncontact meibography. Sirius meibography is a simple, cost-effective method of evaluating meibomian gland dropout as a part of the routine refractive examination.

scholarly journals Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ji Eun Kim ◽  
Na Rae Kim ◽  
Hee Seung Chin ◽  
Kyoung Yul Seo ◽  
Tae-im Kim ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Laboratory Findings ◽  
Surface Parameters ◽  
Primary Sjögren's Syndrome ◽  
Epithelial Damage ◽  
Breakup Time

Abstract Background The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Methods A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5 M were performed, and the Ocular Surface Disease Index was determined. Results In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049). Conclusions Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.

scholarly journals Meibomian gland carcinoma of the lower eyelid: a rare case

2020 ◽  
Vol 8 (11) ◽  
pp. 4152
Author(s):  
Madhusmita Behera ◽  
Subhra Dhar
Keyword(s):  
Rare Case ◽  
Sebaceous Gland ◽  
Lower Eyelid ◽  
Meibomian Gland ◽  
Upper Eyelid ◽  
Tarsal Plate ◽  
Inappropriate Treatment ◽  
Gland Carcinoma ◽  
Meibomian Glands ◽  
Slow Growing

Meibomian gland carcinoma (MGC) is a rare but highly malignant slow growing tumor of the eyelid. MGC usually arises from meibomian gland located in the tarsal plate although rarely it can originates in the gland of zeis, sebaceous gland of caruncle, and periocular skin. MGC is more common in cases of elderly females. Upper eyelid is more commonly affected where the meibomian glands are more. Early diagnosis is very important but in most of the cases the diagnosis is delayed as it mimics chalazion or blepharo-conjunctivitis. This leads to inappropriate treatment and increase in morbidity and/or mortality. Special feature of this carcinoma is that it spread intra-epithelial and causes skipped lesions.

scholarly journals Impact of Unilateral Orbital Radiotherapy on the Structure and Function of Bilateral Human Meibomian Gland

2018 ◽  
Vol 2018 ◽  
pp. 1-7
Author(s):  
Di Chen ◽  
Xiaowei Liu ◽  
Ying Li ◽  
Hui Guan ◽  
Fuquan Zhang
Keyword(s):  
Tear Film ◽  
Lower Eyelid ◽  
Meibomian Gland ◽  
Structure And Function ◽  
Ocular Surface Disease Index ◽  
Orbital Radiotherapy ◽  
Staining Score ◽  
And Function ◽  
The Impact ◽  
Normal Controls

Background. Radiotherapy (RT) has widely been used to treat ocular tumors, yet the impact of orbital radiation to the meibomian gland has rarely been studied. Our study aims at evaluating the bilateral meibomian gland structure and function 12 months after unilateral orbital RT in patients with ocular tumors. Methods. An observational case-control study. A total of 10 eyes 12 months after unilateral orbital RT, 10 contralateral eyes, and 10 normal controls were enrolled. Meibomian gland loss (MGL), lipid layer thickness (LLT), tear film breakup time (TBUT), Schirmer I test, and cornea fluorescein staining were measured. Ocular Surface Disease Index (OSDI) of the RT patients was assessed and compared with normal controls. Results. The cumulative median radiotherapy dosage for the patients was 45 (range: 30, 70) Gy. The OSDI score of the patients was significantly greater than the normal controls (22.92 (range: 10.42, 37.50) vs 6.25 (range: 2.08, 10.42), p≤0.001). Significant differences of upper MGL, lower MGL, LLT, and TBUT were found between the diseased eyes and normal controls (37.79% (range: 12.87, 92.41) vs 12.63% (range: 6.13, 42.34), p=0.007; 61.31% (range: 44.67, 87.98) vs 15.53% (range: 7.65, 45.13), p≤0.001; 40 ICU (range: 23, 100) vs 81.5 ICU (range: 54, 100), p=0.007; 3.5 s (range: 2, 8) vs 6.5 s (range: 5, 10), p=0.002). The upper MGL and TBUT of the contralateral eyes were also considerably damaged compared with normal controls. Lower eyelid MGL and cornea staining score of the diseased eye were significantly correlated with radiation dosage (r = 0.913 and 0.680; p=0.001 and 0.044, respectively). Conclusion. Orbital radiotherapy could cause significant damage to the meibomian gland structure and function, not only the diseased eyes but also the contralateral eyes.

Efficacy of omega-3 fatty acids and punctal plugs in the prevention of isotretinoin-associated ocular surface disease

2020 ◽  
pp. 112067212094565
Author(s):  
Tarek Roshdy Elhamaky
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Omega 3 ◽  
Surface Parameters ◽  
Punctal Plugs ◽  
Staining Score ◽  
Group A ◽  
Corneal Staining

Purpose: To investigate the effects of omega-3 fatty acids and punctal plugs on tear film and ocular surface parameters in patients receiving systemic isotretinoin therapy. Methods: This is a prospective randomized study that included 180 eyes of 90 patients who had systemic isotretinoin therapy (120–150 mg/kg for at least 4–6 months). Exclusion criteria: DED according to the diagnostic criteria of TFOS DEWS II. Patients were assigned into three groups; (1) O3FAs/PPs group: A soft preloaded silicone plug was inserted in the inferior punctum of both eyes and received oral O3FAs two capsules twice daily total daily dose of 1040 mg/day for 6 months. (2) PPs group: A soft preloaded silicone plug was inserted in the inferior punctum of both eyes and received oral placebo. (3) Isotretinoin group: No intervention was done. At baseline, 1 week, 1, 3, and 6 months of study, Ocular surface evaluation tests were done in following order: OSDI, tear osmolarity, Schirmer’s I test, TBUT, ocular surface staining score, and meibomian gland expression. Primary outcome measures: The changes in measurement of ocular surface evaluation tests including ocular surface disease index (OSDI), tear film breakup time (TFBUT), corneal staining, tear osmolarity, and meibomian gland expression at 6 months. Results: There are significant changes between all groups at 6 months follow-up. The ocular surface parameters were better for the PPs and O3FAs/PPs groups than the isotretinoin group. The isotretinoin group showed worsening of ocular surface parameters including a significant decrease of FTBUT and an increase of OSDI score, corneal staining score, tear osmolarity, and meibomian expression score. There was no significant difference in ST1 throughout the whole study in all groups. At 6 months follow-up, there were no statistically significant differences between PPs and O3FAs/PPs groups except meibomian expression score which showed a significant increase in PPs group. Conclusion: Our cohort highlights the beneficial effects of the combination of O3FAs supplementation with PPs in the prevention of isotretinoin-associated OSD in this sample study.

scholarly journals Factors Associated with Ocular Surface Epithelial Damage in Patients with Primary Sjögren's syndrome

2020 ◽  
Author(s):  
Ji Eun Kim ◽  
Na Rae Kim ◽  
Hee Seung Chin ◽  
Kyoung Yul Seo ◽  
Tae Im Kim ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Laboratory Findings ◽  
Surface Parameters ◽  
Primary Sjögren's Syndrome ◽  
Epithelial Damage ◽  
Breakup Time

Abstract Background: The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren's syndrome (pSS).Methods: A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5M were performed, and the Ocular Surface Disease Index was determined. Results: In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 for and β = 0.040, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049).Conclusions: Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.

scholarly journals Congenital Absence of Meibomian Glands: report of two cases

2016 ◽  
Vol 14 (4) ◽  
Author(s):  
Mostafa Mafi ◽  
Rahimi Firouzeh ◽  
Fatemeh Abdi ◽  
Mandana Esfahani ◽  
Nina Faramarzi
Keyword(s):  
Visual Acuity ◽  
Early Childhood ◽  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Congenital Absence ◽  
Blurred Vision ◽  
Film Layer ◽  
Fluorescein Dye ◽  
Meibomian Glands

A 36-year-old man with his 11-year-old son presented with ocular surface irritation symptoms and blurred vision since early childhood, on exam visual acuity of the man was 5/10(OD), 4/10(OS) and his son was 6/10(OD), 5/10(OS), other exams of these patients were similar: eyelid examination showed absence of meibomian gland orifices, after application of fluorescein dye there was a thin tear film layer and diffuse punctuate epithelial erosions on the cornea, remaining exams were unremarkable.

scholarly journals Factors associated with ocular surface epithelial damage in patients with primary Sjögren's syndrome

2021 ◽  
Author(s):  
Ji Eun Kim ◽  
Na Rae Kim ◽  
Hee Seung Chin ◽  
Kyoung Yul Seo ◽  
Tae Im Kim ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Laboratory Findings ◽  
Surface Parameters ◽  
Primary Sjögren's Syndrome ◽  
Epithelial Damage ◽  
Breakup Time

Abstract Background: The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren's syndrome (pSS).Methods: A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5M were performed, and the Ocular Surface Disease Index was determined. Results: In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 for and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049).Conclusions: Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.

scholarly journals The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population

2018 ◽  
Vol 96 (6) ◽  
Author(s):  
Dieter Franz Rabensteiner ◽  
Haleh Aminfar ◽  
Ingrid Boldin ◽  
Gerold Schwantzer ◽  
Jutta Horwath‐Winter
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Surface Parameters ◽  
Clinic Population ◽  
Eye Clinic

scholarly journals Characterization of Meibomian Gland Dysfunction in Patients with Rosacea

2020 ◽  
Author(s):  
Eduardo Buzolin Barbosa ◽  
Carla Melo Tavares ◽  
Dimitri Felipe Luz da Silva ◽  
Lorraine Souza Santos ◽  
Andrea Fernandes Eloy da Costa França ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Rupture Time ◽  
Meibomian Gland Dysfunction ◽  
Ocular Involvement ◽  
Conjunctival Hyperemia ◽  
Film Rupture ◽  
Glandular Secretion

Abstract Background: Rosacea frequently evolve the eyes with impact on life and vision quality. There are gaps in the understanding of ocular involvement, specially related to eyelid glands, which share common features to sebaceous glands.Purpose: Describe ocular surface disease related to Rosacea and its associations.Methods: Ninety-three individuals were selected to this cross-sectional, observational, non-interventionist study, divided into groups: rosacea (n=40) and controls (n=53). We investigated objective parameters of the ocular surface (conjunctival hyperemia, tear film stability and volume, meibomian gland dysfunction, dry eye disease, ocular surface staining) comparing healthy individuals with rosacea patients.Results: 69.23% of rosacea group were women, mean age of 47.34 ± 12.62 years old. Compared to matched controls there was no statistically significant differences regarding to visual acuity (p=0.987) and tear film parameters (tear meniscus height (p=0.338), non-invasive tear film rupture time (NIBUT) (p= 0.228), invasive rupture time (TBUT) (p=0.471) and Schirmer's test (p=0.244)) as well as conjunctival hyperemia (p = 0.106), and fluorescein staining (p = 0.489). Significant association was found in meibography evaluation (p = 0.026), mucous layer integrity (p = 0.015) and ocular surface symptoms (p <0.0001). Rosacea patients also showed important eyelid changes: glandular expressibility (p <0.001), glandular secretion pattern (p <0.001) and telangiectasia (p <0.001) compared to controls.Conclusion: Meibomian gland dysfunction is frequently associated to dermatologic conditions and is characterized by morphological findings in the meibography as well as lipid secretion impairment that lead to evaporative dry eye and ocular surface dysfunction and inflammation.

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