scholarly journals Association between development of early cortical activity on amplitude-integrated EEG and 5-years neurodevelopmental outcome in the preterm infant

2019 ◽  
Author(s):  
Maria Feldmann ◽  
Valentin Rousson ◽  
Thi Dao Nguyen ◽  
Vera Bernet ◽  
Cornelia Hagmann ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Neonatal Morbidity ◽  
Population Group ◽  
Cognitive Outcome ◽  
List Type ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Preterm Born

AbstractAimTo analyse the association between early aEEG and cognitive outcome at early school-age in very preterm infants.MethodsProspective cohort study including infants with gestational age (GA) <32.0 weeks, undergoing continuous aEEG recording during first 4 days of life. Semiquantitative and quantitative (maximum/minimum amplitude) measures were averaged over the recording period. Cognitive outcome was assessed with the Kaufman-Assessment Battery for Children at 5 years of age. Uni- and multivariate logistic regressions were calculated between aEEG parameters and normal cognitive outcome (IQ≥85).ResultsAmong 118 monitored preterm children, 89 were assessed at median(IQR) corrected age of 68.6 months (65.5-71.2) [48% female, median(IQR) GA 29.9(28.2,30.9) weeks, mean(SD) birth weight 1235(363) grams]. Mean(SD) IQ was 97.8(12.7). IQ<85 occurred in 21.3 %, cerebral palsy was found in 3.4%. Despite univariate associations of total maturity scores, cycling subscores, background pattern and minimum aEEG amplitude with normal cognitive outcome none of the associations remained significant after adjustment for confounders. Socioeconomic status was identified as independent predictor of neurodevelopmental outcome.ConclusionIn this cohort of very preterm infants, early short-term aEEG was not predictive of later cognitive outcome. Further research is needed to explore how aEEG could help to inform long-term prognosis in this population group.Key notesPreterm born infants are at high risk for neurodevelopmental impairment.Early amplitude integrated electroencephalography characteristics are univariately associated with cognitive outcome at 5 years of age in preterm born children.However, socioeconomic factors and neonatal morbidity were stronger predictors of long-term neurodevelopmental outcome than early aEEG measures.

scholarly journals Postnatal Serum Total Thyroxine of Very Preterm Infants and Long-Term Neurodevelopmental Outcome

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1055
Author(s):  
Yung-Chieh Lin ◽  
Chen-Yueh Wang ◽  
Yu-Wen Pan ◽  
Yen-Ju Chen ◽  
Wen-Hao Yu ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Congenital Hypothyroidism ◽  
Brain Injuries ◽  
Neurodevelopmental Outcome ◽  
Term Infants ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Total Thyroxine ◽  
Tsh Levels

Primary congenital hypothyroidism is a disease associated with low serum thyroxine and elevated thyroid-stimulating hormone (TSH) levels. The processes of screening and treating congenital hypothyroidism, in order to prevent neurodevelopmental impairment (NDI) in newborns, have been well investigated. Unlike term infants, very preterm infants (VPIs) may experience low thyroxine with normal TSH levels (<10.0 μIU/mL) during long-stay hospitalization. In the current literature, thyroxine treatment has been evaluated only for TSH-elevated VPIs. However, the long-term impact of low thyroxine levels in certain VPIs with normal TSH levels deserves more research. Since July 2007, VPIs of this study unit received screenings at 1 month postnatal age (PNA) for serum TSH levels and total thyroxine (TT4), in addition to two national TSH screenings scheduled at 3–5 days PNA and at term equivalent age. This study aimed to establish the correlation between postnatal 1-month-old TT4 concentration and long-term NDI at 24 months corrected age among VPIs with serial normal TSH levels. VPIs born in August 2007–July 2016 were enrolled. Perinatal demography, hospitalization morbidities, and thyroid function profiles were analyzed, and we excluded those with congenital anomalies, brain injuries, elevated TSH levels, or a history of thyroxine treatments. In total, 334 VPIs were analyzed and 302 (90.4%) VPIs were followed-up. The postnatal TT4 concentration was not associated with NDI after multivariate adjustment (odd ratios 1.131, 95% confidence interval 0.969–1.32). To attribute the NDI of TSH-normal VPIs to a single postnatal TT4 concentration measurement may require more research.

scholarly journals Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome

2019 ◽  
Vol 60 (2) ◽  
pp. 178-185 ◽  
Author(s):  
Po-Ming Wu ◽  
Hsin-I. Shih ◽  
Wen-Hao Yu ◽  
Li-Wen Chen ◽  
Lie-Chuan Wang ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Cerebellar Vermis ◽  
Very Preterm Infants ◽  
Very Preterm

scholarly journals Maternal Vaginal Ureaplasma spp. Colonization in Early Pregnancy Is Associated with Adverse Short- and Long-Term Outcome of Very Preterm Infants

Children ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 276
Author(s):  
Judith Rittenschober-Böhm ◽  
Tanja Habermüller ◽  
Thomas Waldhoer ◽  
Renate Fuiko ◽  
Stefan M. Schulz ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Early Pregnancy ◽  
Short Term ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Vaginal Colonization ◽  
Short And Long Term

Vaginal colonization with Ureaplasma (U.) spp. has been shown to be associated with adverse pregnancy outcome; however, data on neonatal outcome are scarce. The aim of the study was to investigate whether maternal vaginal colonization with U. spp. in early pregnancy represents a risk factor for adverse short- or long-term outcome of preterm infants. Previously, 4330 pregnant women were enrolled in an observational multicenter study, analyzing the association between vaginal U. spp. colonization and spontaneous preterm birth. U. spp. colonization was diagnosed via PCR analysis from vaginal swabs. For this study, data on short-term outcome were collected from medical records and long-term outcome was examined via Bayley Scales of Infant Development at 24 months adjusted age. Two-hundred-and-thirty-eight children were born <33 weeks gestational age. After exclusion due to asphyxia, malformations, and lost-to-follow-up, data on short-term and long-term outcome were available from 222 and 92 infants, respectively. Results show a significant association between vaginal U. spp. colonization and severe intraventricular hemorrhage (10.4% vs. 2.6%, p = 0.03), retinopathy of prematurity (21.7% vs. 10.3%, p = 0.03), and adverse psychomotor outcome (24.3% vs. 1.8%, OR 13.154, 95%CI 1.6,110.2, p = 0.005). The data suggest an association between vaginal U. spp. colonization in early pregnancy and adverse short- and long-term outcome of very preterm infants.

scholarly journals Circulatory insulin-like growth factor-I and brain volumes in relation to neurodevelopmental outcome in very preterm infants

2013 ◽  
Vol 74 (5) ◽  
pp. 564-569 ◽  
Author(s):  
Ingrid Hansen-Pupp ◽  
Holger Hövel ◽  
Chatarina Löfqvist ◽  
Lena Hellström-Westas ◽  
Vineta Fellman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Insulin Like Growth Factor ◽  
Brain Volumes ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Factor I ◽  
Growth Factor I

scholarly journals Ultrasound appearance of the brain in very preterm infants and neurodevelopmental outcome at 18 months of age.

1983 ◽  
Vol 58 (8) ◽  
pp. 598-604 ◽  
Author(s):  
A L Stewart ◽  
R J Thorburn ◽  
P L Hope ◽  
M Goldsmith ◽  
A P Lipscomb ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Neurodevelopmental Outcome ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
The Brain
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