scholarly journals Dynamics, cariogenicity, and geographic distribution of Streptococcus mutans adhesin types suggest adaptation to individual hosts

2019 ◽  
Author(s):  
Nongfei Sheng ◽  
Anders Esberg ◽  
Lena Mårell ◽  
Elisabeth Johansson ◽  
Carina Källestål ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Dental Caries ◽  
Streptococcus Mutans ◽  
Geographic Distribution ◽  
Caries Experience ◽  
Geographic Differentiation ◽  
Caries Increment ◽  
Whole Saliva

AbstractDental caries, the most common chronic infectious disease, involve Streptococcus mutans SpaP A/B/C and Cnm/Cbm adhesin types of different virulence. We have explored their stability and dynamics over 5 years, their geographic distribution, as well as the potentially increased cariogenicity of specific SpaP B subtypes. We performed qPCR and TaqMan typing using whole saliva and isolates from 452 Swedish adolescents followed from 12 to 17 years of age. Approximately 50% of the children were infected at baseline with a single dominant (44%) or mixed (6%) SpaP A, B, or C type, some of which were also Cnm (6%) or Cbm (1%) positive. Stability (+, +) was high for S. mutans infection (85%) and dominant SpaP A or C (80% and 67%) and Cnm or Cbm (85% and 100%) types, but low for SpaP B (51%) and mixed SpaP A/B/C types (26%). Only five children switched from one SpaP type to another, and none between Cnm and Cbm types. Mixed SpaP A/B/C types were typically lost or changed into dominant types. Moreover, children infected with Cnm (n=26) types were more frequent in the northern (Skellefteå) region (p = 0.0041), and those with Cbm types (n=7) in the southern (Umeå) region. Children infected with SpaP B-2 subtypes had a doubled caries experience (p = 0.009) and 5-year caries increment (p = 0.02) compared to those infected with SpaP A. In conclusion, the stable dominant but instable mixed adhesin types and geographic differentiation of Cnm and Cbm types suggest adaptation of low and high cariogenicity types to specific individuals.

Evaluation of Dental Caries Experience and Salivary Immunoglobulins in Whole Saliva

1972 ◽  
Vol 51 (5) ◽  
pp. 1487-1491 ◽  
Author(s):  
D.L. Everhart ◽  
W.R. Grigsby ◽  
W.H. Carter
Keyword(s):  
Dental Caries ◽  
Caries Experience ◽  
Whole Saliva

scholarly journals Correlation between the salivary Streptococcus mutans levels and dental caries experience in adult population of Chandigarh, India

2013 ◽  
Vol 07 (02) ◽  
pp. 191-195 ◽  
Author(s):  
Parampreet Pannu ◽  
Ramandeep Gambhir ◽  
Amrita Sujlana
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Adult Population ◽  
Positive Association ◽  
Caries Experience ◽  
Bacterial Titer ◽  
Males And Females ◽  
The Mean ◽  
Sample Score ◽  
Commercial Kits

ABSTRACT Objective: To determine the level of Streptococcus mutans (S. mutans) in adults of Chandigarh and to correlate the dental caries in these individuals with their S. mutans titers. Materials and Methods: Salivary levels of Streptococcus mutans, using Dentocult SM commercial kits were estimated in 200, 25-35 year old adults (males and females). Streptococcus mutans were detected in 87% of the study sample. Score 2, representing 105 - 106 CFU/ml (Colony Forming Unit) of saliva was found to be most prevalent, i.e. in 80 of 200 adults, followed by score 1, depicting S mutans with <105 CFU/ml, in 56 of 200 adults and score 3, with bacterial titer <106 CFU/ml in 38 of 200 adults. Results: Dental caries, recorded using Møller′s index, was found to be maximum in individuals with score 3, followed by score 2,1 and 0, thereby showing a positive correlation of dental caries with increasing titers of S. mutans. This correlation was statistically highly significant in males with figures as 8.73 decayed surfaces at score 2 rising to 17.38 at score 3. The mean of DMFT was higher among females than in the males in the present study. Conclusion: The split up data in males and females, showed a positive association between caries experience and salivary S. mutans scores. The results of the study will serve as a baseline data for future planning of preventive programs in adults.

Sugars Consumption of Northumbrian Children Aged 11–14 Years

1987 ◽  
Vol 5 (1-2) ◽  
pp. 19-23 ◽  
Author(s):  
A F. Hackett ◽  
A. J. Rugg-Gunn ◽  
D. R. Appleton
Keyword(s):  
Longitudinal Study ◽  
Dental Caries ◽  
Health Education ◽  
Dietary Factors ◽  
Caries Experience ◽  
Older Children ◽  
Cross Sectional ◽  
Caries Increment ◽  
The Uk ◽  
The Relationship

In order to investigate the relationships between diet and tooth decay the authors recently completed the first longitudinal study of diet and dental caries increment in children. 405 children initially aged 11.5 years each recorded their intake of foods and drinks for a total of 15 days over a period of 2 years. This is a review of some of the findings. The evidence implicating consumption of sugars in the causation of dental caries is both diverse and overwhelming (Rugg-Gunn, 1983). Of the 30 or so observational studies relating diet and dental caries in children, all except one have been cross-sectional in design. Such a design is unsatisfactory in older children at least because there is little reason why a lifetime's caries experience should be related to a single estimate of dietary intake. In addition there have been few reports of the food intake in general, and sugars intake in particular, of children in the UK. A longitudinal survey of intake could indicate how choice of foods changes with age and if repeated could show how preferences change over time. The National Food Survey has provided some information on food acquisition (not consumption) over the past 40 years (Derry and Buss, 1984). Unfortunately, besides not estimating consumption this survey does not include foods bought and consumed away from the home such as confectionery and soft drinks. Furthermore, this survey collects data by household and so information for age and sex specific groups is not available. Comments regarding sugars consumption amongst children must be derived from data collected from properly designed dietary surveys of defined groups of individuals. Such knowledge of what children eat is essential to the planning of effective health education campaigns. In order to contribute to the understanding of the relationship between diet and caries in children and to contribute to health education a longitudinal study was undertaken which had the following aim: to rank some defined dietary factors either singly or in combination in the order in which they explain the dental caries increment of over 400 children.

scholarly journals Interdental Localization of Streptococcus mutans as Related to Dental Caries Experience

1974 ◽  
Vol 9 (3) ◽  
pp. 481-488 ◽  
Author(s):  
R. J. Gibbons ◽  
P. F. Depaola ◽  
D. M. Spinell ◽  
Z. Skobe
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Caries Experience

scholarly journals Genotypic diversity of Streptococcus mutans isolated from preschoolers with and without early dental care

2019 ◽  
Vol 48 ◽  
Author(s):  
Ana Lídia Soares COTA ◽  
Janaína Accordi JUNKES ◽  
Regina Célia POLI-FREDERICO
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Dental Care ◽  
Random Amplified Polymorphic Dna ◽  
Genotypic Diversity ◽  
Caries Experience ◽  
Oral Microbiota ◽  
Preventive Program ◽  
Arbitrary Primers ◽  
History Of

Abstract Introduction Streptococcus mutans (S. mutans) exhibits extensive genotypic diversity, but the role of this variation is poorly understood. Objective To evaluate the genotypic diversity of S. mutans in preschoolers with and without early dental care and to associate it with dental caries experience. Material and method Twenty children, aged five year old, with history of dental care since they were one year old (G1) and 20 children without history of dental care (G2) were included. Their oral health status was assessed by the dmft index. S. mutans samples were isolated from the saliva and analysed by polymerase chain reaction. A total of 339 S. mutans isolates (173 from G1 and 166 from G2) were genotyped by random amplified polymorphic DNA with arbitrary primers OPA-02 and OPA-13. Result The results revealed 75 distinct genotypes of S. mutans in G1 and 73 in G2. Furthermore, G1 and G2 subjects harboured one to eight and one to seven distinct genotypes of S. mutans, respectively. A statistically significant association (P=0.021) and a moderate correlation (r= 0.503) were observed between dental caries experience and genotypic diversity of S. mutans in G1. Conclusion From the limitations of the study design, we just can hypothesize that actions of early dental care carried out by an educative-preventive program can contribute to a distinct oral microbiota.

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